In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica

Shukla, Amritesh C.; Rasik, Anamika M.; Jain, Girish Kumar; Shankar, Ravi; Kulshrestha, D. K.; Dhawan, B. N.

doi:10.1016/s0378-8741(98)00141-x

Cited by 343 publications

(235 citation statements)

References 9 publications

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“…While the effects of CaE on the neurovasculature have yet to be studied in detail, an alteration of extracellular matrix composition may play a role in regulating the clearance of amyloid β or the deposition as visible plaques. Centella asiatica has also shown to regulate dermal fibroblast associated genes that contribute to wound healing, including genes involved in extracellular matrix synthesis (Shukla et al, 1999;Maquart et al, 1999;Widgerow et al, 2000;Cataldi et al, 2001;Coldren et al, 2003;Lu et al, 2004). Deposition of fibrillar amyloid β can be promoted by the extracellular matrix molecule, perlecan or fibril formation inhibited by another extracellular matrix molecule, laminin (Holcomb et al, 2000;Castillo et al, 2000).…”

Section: Resultsmentioning

confidence: 99%

Centella asiatica extract selectively decreases amyloid β levels in hippocampus of Alzheimer's disease animal model

Dhanasekaran

Holcomb

Hitt

et al. 2008

Phytotherapy Research

166

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PSAPP mice expressing the 'Swedish' amyloid precursor protein and the M146L presenilin 1 mutations are a well-characterized model for spontaneous amyloid β β β β β plaque formation. Centella asiatica has a long history of use in India as a memory enhancing drug in Ayurvedic literature. The study investigated whether Centella asiatica extract (CaE) can alter the amyloid pathology in PSAPP mice by administering CaE (2.5 or 5.0 g/kg/day) starting at 2 months of age prior to the onset of detectable amyloid deposition and continued for either 2 months or 8 months. A significant decrease in amyloid β β β β β 1-40 and 1-42 was detectable by ELISA following an 8 month treatment with 2.5 mg/kg of CaE. A reduction in Congo Red stained fibrillar amyloid plaques was detected with the 5.0 mg/kg CaE dose and long-term treatment regimen. It was also confirmed that CaE functions as an antioxidant in vitro, scavenging free radicals, reducing lipid peroxidation and protecting against DNA damage. The data indicate that CaE can impact the amyloid cascade altering amyloid β β β β β pathology in the brains of PSAPP mice and modulating components of the oxidative stress response that has been implicated in the neurodegenerative changes that occur with Alzheimer's disease.

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Section: Resultsmentioning

confidence: 99%

Centella asiatica extract selectively decreases amyloid β levels in hippocampus of Alzheimer's disease animal model

Dhanasekaran

Holcomb

Hitt

et al. 2008

Phytotherapy Research

166

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“…Asiatic acid found in Centella asiatica (Niranjan et al, 1989) has been traditionally used as a tonic in skin diseases and leprosy (Shukla et al, 1999) whereas arjunolic acid has been isolated from Syzygium samarangense (Srivastava et al, 1995) and Syzygium cordatum (Candy et al, 1968). Arjunolic and asiatic acid isolated from Syzygium claviflorum were identified as anti-HIV agents with IC 50 of 36 and 8 g/ml (Yoshiki et al, 1998), but this is the first time that their antibacterial activity specially on human pathogen bacteria is reported.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial triterpenes from Syzygium guineense (Myrtaceae)

Djoukeng

Abou-Mansour

Tabacchi

et al. 2005

Journal of Ethnopharmacology

143

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Antibacterial bioassay-guided fractionation of Syzygium guineense leaf extracts afforded 10 triterpenes, namely betulinic acid 1, oleanolic acid 2, a mixture of 2-hydroxyoleanolic acid 3a, 2-hydroxyursolic acid 3b, arjunolic acid 4a, asiatic acid 4b, a mixture of terminolic acid 5a, 6-hydroxyasiatic acid 5b, and a mixture of arjunolic acid 28-␤-glucopyranosyl ester 6a and the asiatic acid 28-␤-glucopyranosyl ester 6b. Isolated compounds were submitted to an antibacterial assay system against gram-positive and -negative bacteria and human pathogen bacteria. Compounds 4a and 4b showed the most significant antibacterial activity against Escherichia coli, Bacillus subtilis and Shigella sonnei. The fraction 5a-5b was the least active, whereas compounds 1, 2 and the mixtures of 3a-3b and 6a-6b were inactive in the assays.

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“…The antimicrobial activities of saponins were confirmed against different microorganisms [23][24][25]. Saponins are detergent like substance and with surface active properties may disturb the bacterial membrane cells of bacteria [26].…”

Section: Antibacterial Activity Of Tribulus Terrestris Methanol Extramentioning

confidence: 93%

Antibacterial activity of Tribulus terrestris methanol extract against clinical isolates of Escherichia coli

Batoei

Mahboubi²,

Yari

2016

Herba Polonica

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S u m m a r yIntroduction: Tribulus terrestris L. is traditionally used for treatment of urinary tract infections. Escherichia coli, as the most prominent agent of urinary tract infections, can be sensitive to T. terrestris extract. Objectives: The aim of this study was to evaluate the antibacterial activity of T. terrestris methanol extract against clinical isolates of E. coli from urinary tract infections. Saponins were determined as main constituents of T. terrestris methanol extract. Methods: The antibacterial activities of T. terrestris methanol extract were evaluated by micro-broth dilution assay. The synergistic effects of T. terrestris methanol extract were screened with gentamicin by micro titer plate and disc diffusion assays. The isobologram curve was figured and the Fractional Inhibitory Concentration Index (FICI) was determined. Results: The saponin content of T. terrestris methanol extract was 54% (w/w). The means of MIC and MBC values for E. coli clinical isolates (n=51) were 3.5±0.27 and 7.4±0.5 mg/ml while these amounts were 3.9±1.3 and 6.4±1.8 µg/ml for gentamicin. T. terrestris methanol extract and gentamicin had synergistic effect with FICI equal to 0.1375. Conclusion: Therefore, T. terrestris can be applicable as alternative treatment in management of urinary tract infections.

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In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica

Cited by 343 publications

References 9 publications

Centella asiatica extract selectively decreases amyloid β levels in hippocampus of Alzheimer's disease animal model

Centella asiatica extract selectively decreases amyloid β levels in hippocampus of Alzheimer's disease animal model

Antibacterial triterpenes from Syzygium guineense (Myrtaceae)

Antibacterial activity of Tribulus terrestris methanol extract against clinical isolates of Escherichia coli

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