In vitro and in vivo antihypertensive activity of palm kernel cake protein hydrolysates: Sequencing and characterization of potent bioactive peptides

ACE-inhibitory and antioxidant peptides from coconut cake albumin hydrolysates: purification, identification and synthesis

“…In addition, Zareia et al have iden-tied a peptide (Lys-Ile-Ile-Ile-Tyr) from palm kernel cake proteins, which had a similar amino acid sequence with the peptide Lys-Ile-Ile-Ile-Tyr-Asn obtained the current study. 38 However, KIIIY demonstrated higher ACE-inhibitory ability (IC 50 : 47.00 AE 1.60 mM) than that of KIIIYN (IC 50 : 58.72 mM) obtained in the current study. This proves once again that an aromatic amino acid residue in the C-terminal is very important to the ACE-inhibitory activity of peptides.…”

Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds

“…Protein hydrolysates from palm kernel administered to rats (150 mg/kg, 75 mg/kg and 37.5 mg/kg). Different doses of hydrolysate concentration resulted in various SBP level and the highest modulating activity in rats was observed at 75 mg/kg hydrolysate [179].…”

Identification, structure-activity relationship andin silicomolecular docking analyses of five novel angiotensin I-converting enzyme (ACE)-inhibitory peptides from stone fish hydrolysates

“…Majority of the previously reported ACE-inhibitory peptides derived from food sources contain pro and aromatic amino acids such as Tyr, Tryp or Phe at their C terminal (4, 16, 24, 28) and/or branched aliphatic amino acids such as Val, Leu, Ile at their N terminal (23). The positively charged amino acids arginine (R) and lysine (K) present at the C-terminal were also found to contribute to the ACE inhibitory potency of peptides (29).…”

“…Consequently, increased awareness about the significance of healthy diet has led to the recent development of biologically active peptides through enzymatic hydrolysis of food proteins. The peptides consists of specific amino acids sequences and perform at least one or more physiological role on the body system including; antihypertensive activity (1 - 4), antioxidant activity (5 - 6), antibacterial activity (7), anti-inflammatory and opioids activities (8).…”