In vitro and in silico analysis of the effect of fluconazole, an antifungal drug, on DNA

Abstract

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Polycaprolactone Microsphere‐Encapsulated Fluconazole‐Loaded Zinc Oxide and Hydroxyapatite Nanocomposites for Enhanced Biological Performance

“…After 24 h of culture at 150 rpm at 37 °C, the strains’ viability and growth were evaluated using a UV‐visible spectrophotometer and colony‐forming unit (CFU) count. Treatment with a concentration‐dependent fluconazole preparation inhibited the development of Enterobacter cloacae, Enterococcus faecalis, Escherichia coli, and Proteus mirabilis [13] . However, fluconazole treatment in vitro resulted in a considerable decline in neutrophil bactericidal activity [14] .…”

“…Treatment with a concentrationdependent fluconazole preparation inhibited the development of Enterobacter cloacae, Enterococcus faecalis, Escherichia coli, and Proteus mirabilis. [13] However, fluconazole treatment in vitro resulted in a considerable decline in neutrophil bactericidal activity. [14] To the best of our knowledge, there is no report on the development of fluconazole based ZnO and Hap nanocrystaline encapsulated with PCL biopolymer in the literature.…”