In vitro and in silico perspectives on biological and phytochemical profile of three halophyte species—A source of innovative phytopharmaceuticals from nature

Zengin, Gökhan; Aumeeruddy-Elalfi, Zaahira; Mollica, Adriano; Yılmaz, Mustafa Abdullah; Mahomoodally, Mohamad Fawzi

doi:10.1016/j.phymed.2017.10.017

Cited by 65 publications

(46 citation statements)

References 63 publications

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“…Field cultivated BTH2 plants had an average FPC content higher than that of ethanolic and methanolic extracts of the vegetative shoots of green (respectively, 1.89 and 1.94 mg GAE g −1 dw; calculated considering 80% shoot water content) and red (respectively, 2.20 and 2.35 mg GAE g −1 dw) wild biotypes of S. neei from southern Brazil, cultivated with saline effluent of shrimp farm [12]. Free phenolic compounds and FFC of BTH2 shoots were higher than those found in methanolic extracts of wild plants of Sarcocornia perennis from Tunisia [37] and Salicornia europaea collected in Tukey [38], which range between 4.32-9.89 mg GAE g −1 dw and 3.3-5.1 mg catechin equivalent (ce) g −1 dw, respectively. The content of phenolic compounds in BTH2 shoots was also equal or greater than that of organic asparagus (FPC = 19.4 mg GAE g −1 dw; FFC = 5.28 mg ce g −1 dw) [39], artichoke (FPC = 0.84 mg GAE g −1 dw; FFC = 0.65 mg ce g −1 dw), spinach (FPC = 0.6 mg GAE g −1 dw; FFC = 0.03 mg ce g −1 dw) [40], broccoli and cauliflower (FPC ranged from 8.24 to 17.2 mg GAE g −1 dw) [41].…”

Section: Responses Of S Neei Genotypes Under Saline Effluent Irrigatmentioning

confidence: 86%

Growth, Phenolics, Photosynthetic Pigments, and Antioxidant Response of Two New Genotypes of Sea Asparagus (Salicornia neei Lag.) to Salinity under Greenhouse and Field Conditions

et al. 2018

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Small succulent halophytic shrubs of the genera Salicornia and Sarcocornia (Salicornioideae, Amaranthaceae) are commonly named sea asparagus and consumed worldwide as green salad in gourmet food, as conserves, and beverages. Their shoots are rich in bioactive compounds and plants show high yields in a wide range of salinities, but little is known about how salt cultivation conditions affect their chemical composition. Two genotypes (BTH1 and BTH2) of the Brazilian sea asparagus Salicornia neei Lag. were evaluated for salt tolerance and changes in shoot concentrations of organic metabolites and antioxidant activity under different salt exposure in both greenhouse and field conditions. All greenhouse plants received full strength modified Hoagland solution in deionized water with a basic electrical conductivity (EC) of 1.7 dS m−1, and with NaCl concentrations (in mM) of ~0.1 (control), 34, 86, 171, 513, and 769. After fifty days of cultivation, both S. neei genotypes showed high salt tolerance and grew better under low salinities (34–86 mM NaCl) than under control salinity. Shoots of BTH1 genotype appeared to be undergoing lignification and used their high carotenoid content to dissipate the oxidative power, and the zeaxanthin content and de-epoxidation state of xanthophylls (DES) were positively affected by salinity. Under increasing salinity, BTH2 genotype had higher relative content of chlorophyll b, which may have lowered the plant photo-oxidation rate, and increased shoot concentration of the flavonoid quercetin (up to 11.6 μg g−1 dw at 769 mM NaCl), leading to higher antioxidant capacity. In the field experiment, after 154 days of irrigation with saline (213 mM NaCl) shrimp farm effluent, BTH2 plants grew taller, produced more metabolites (e.g., total phenolics, total free flavonoids, quercetin, and protocatechuic acid) and had a greater antioxidant capacity of shoots than that of BTH1 plants and that of traditional crops irrigated with fresh water. Yield and bioactive compound composition of S. neei genotypes’ shoots can be enhanced by cultivation under moderate saline conditions.

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Section: Responses Of S Neei Genotypes Under Saline Effluent Irrigatmentioning

confidence: 86%

Growth, Phenolics, Photosynthetic Pigments, and Antioxidant Response of Two New Genotypes of Sea Asparagus (Salicornia neei Lag.) to Salinity under Greenhouse and Field Conditions

et al. 2018

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“…Several plant secondary metabolites such as isoorientin, isovitexin [63], and kaempferol [64] have been reported to inhibit AChE. As oxidative stress has been purported as one of underlying causes of AD generation and progression, plants extracts with significant antioxidant capacities are assumed to exhibit inhibitory activity against AChE [65][66][67]. In the present study, the ethyl extract followed FE has exhibited higher AChE (2.12 AE 0.06 mgGALAE/g extract) and BChE (2.01 AE 0.16 mgGALAE/g extract) inhibition, which tallies with its antioxidant potency (Table IV).…”

Section: Enzyme Inhibitory Effectsmentioning

confidence: 99%

Multiple pharmacological approaches on Fibigia eriocarpa extracts by in vitro and computational assays

Zengin

Lobine

Mollica

et al. 2018

Fundamemntal Clinical Pharma

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The ethyl acetate, methanolic, and water extracts of Fibigia eriocarpa were assessed for a panoply of bioactivities. Total phenolic and flavonoid content were quantified as well as individual phenolic compounds by HPLC-DAD. The in vitro antioxidant and enzyme (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, α-amylase, and α-glucosidase) inhibitory potential of the extracts were evaluated. In silico molecular docking was used to investigate possible interaction between dominant compounds and selected enzymes. Vanillin (303 μg/g extract), apigenin (270 μg/g extract), and kaempferol (180 μg/g extract) were the main compounds in the ethyl acetate extract, while the methanolic extract was characterized by the presence of vanillin, rutin, and apigenin (616, 616 and 252 μg/g extract, respectively). (+)-catechin (1422 μg/g extract) was the main compound in the water extracts. The ethyl acetate extract was found to be a superior source of antioxidant compounds and enzyme inhibitors against above-mentioned enzymes. Docking studies revealed that p-hydroxybenzoic and (+)-catechin have the best scores for tyrosinase, while kaempferol and apigenin showed the best binding pose for α-glucosidase, AChE, and BChE. Results amassed herein are the first report on the phytochemical and biological attributes of F. eriocarpa, which tend to validate the pharmacological uses of this plant as an alternative medicine.

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“…The antioxidant activity of the extracts of Arthrocaulon macrostachyum, Atriplex portulacoides, and Salicornia europaea coupled with their inhibition of α-amylase and α-glucosidase could be part of the mechanism by which the active compounds manage and/or prevent type 2 diabetes (Zengin et al 2018). The bioactive substances identified in the extracts (notably rhamnetin and quinic acid, 4-OH benzoic acid, and p-coumaric acid but also malic acid, tr-aconitic acid, chlorogenic acid, tr-caffeic acid, rosmarinic acid, hesperidin, rutin, salicylic acid, and hyperoside) display potent anti-inflammatory and anti-tyrosinase activities and anticholinesterase potential and…”

Section: Secondary Metabolitesmentioning

confidence: 99%

“…therefore represent key compounds in the management of various diseases (such as chronic inflammation, melanoma, and neurodegenerative diseases) (Zengin et al 2018). Dudai et al (2008) have shown the antioxidant activity of Suaeda vera extracts.…”

Section: Secondary Metabolitesmentioning

confidence: 99%

Ethnopharmacology and Medicinal Uses of Extreme Halophytes

Obón

Rivera

López³

et al. 2020

Handbook of Halophytes

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In vitro and in silico perspectives on biological and phytochemical profile of three halophyte species—A source of innovative phytopharmaceuticals from nature

Cited by 65 publications

References 63 publications

Growth, Phenolics, Photosynthetic Pigments, and Antioxidant Response of Two New Genotypes of Sea Asparagus (Salicornia neei Lag.) to Salinity under Greenhouse and Field Conditions

Growth, Phenolics, Photosynthetic Pigments, and Antioxidant Response of Two New Genotypes of Sea Asparagus (Salicornia neei Lag.) to Salinity under Greenhouse and Field Conditions

Multiple pharmacological approaches on Fibigia eriocarpa extracts by in vitro and computational assays

Ethnopharmacology and Medicinal Uses of Extreme Halophytes

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