In Vitro Alveolar Macrophage Viability

Weissbecker, L; Carpenter, Robert D.; Luchsinger, Peter C.; Osdene, T. S.

doi:10.1080/00039896.1969.10665483

Cited by 31 publications

(2 citation statements)

References 10 publications

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“…A similar impairment (22) after in vitro exposure of normal macrophages to smoke has also been reported. However, other investigators (102)(103)(104) reported that macrophages from cigarette smokers had enhanced responsiveness to a chemotactic stimulus and an impaired responsiveness to macrophage migration factor.…”

Section: Alterations In Phagocytosismentioning

confidence: 98%

Alterations in macrophage functions by environmental chemicals.

Gardner¹

1984

Environ Health Perspect

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The establishment of infectious diseases is rarely entirely attributed to a single entity, but instead is the result of a primary stress and one or more secondary factors that interfere with homeostasis and the ability of the host to cope with the primary etiologic assault. Any environmental chemical that can suppress the normal functioning of the host's body defenses would be expected to increase the risk of the host to such diseases. Within the lung, the alveolar macrophages are the crucial elements responsible for defending the body against such airborne viable agents. The effects of inhaled gases and particulates on these defense cells are a major concern of the environmental health scientist since such chemicals have the capability of adversely affecting the integrity and functioning of these pulmonary defense cells. The objective of this report is to provide an overview that will improve our understanding of how a variety of environmental chemicals can alter the biochemical, physiological and immunological functioning of these cells.

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Section: Alterations In Phagocytosismentioning

confidence: 98%

Alterations in macrophage functions by environmental chemicals.

Gardner¹

1984

Environ Health Perspect

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“…The most readily demonstrable phenomenon is decreased cell viability after exposure. At relatively low concentrations, TS, 03, SO2, and NO2 rapidly kill alveolar and peritoneal macrophages in vitro (40,43,73,114), whereas such agents as CO2, CO, CH4, CH3Cl, acrolein, and acetaldehyde are ineffective at comparable concentrations (114). Lymphocytes may be even more susceptible than macrophages to the lethal effects ofthese agents (40).…”

Section: Smoking Air Pollution and Immune Function-animal Modelsmentioning

confidence: 99%