In Vitro Aerosol Delivery and Regional Airway Surface Liquid Concentration of a Liposomal Cationic Peptide

Toward Modern Inhalational Bacteriophage Therapy: Nebulization of Bacteriophages ofBurkholderia cepaciaComplex

“…This type of nebulizer is commonly used in CF therapy and has demonstrated good performance in previous nebulization studies. (36)(37)(38)(39)(40) The second tested nebulizer in this study was the recently developed eFlow electronic nebulizer (Pari Pharma GmbH). The latter nebulizer has a shorter nebulization time and its gentle aerosol generation has demonstrated the potential to exert less shear on the fluid in the aerosolization of large molecules.…”

Recent advances in topical delivery of proteins and peptides mediated by soft matter nanocarriers

“…An antimicrobial peptide could be successfully encapsulated and nebulized with liposomes of different lipid combinations; dimyristoylphosphatidyl choline/dimyristoyl phosphatidylglycerol 3:1 being the most promising combination. The formulations should allow for adequate peptide levels in adults and even more so in children (Lange et al, 2001). Systemic peptide delivery was tested with the GnRH analog leuprolide used in cancer and endometriosis treatment.…”

Improving the Likelihood of Success in Trials and the Efficiency of Delivery of Mucolytics and Antibiotics

“…The model of the Airway Surface Liquid (ASL) layer, developed at the University of Alberta by the author in collaboration with W. Finlay and M. King (Finlay, Lange, King & Speert (2000); Hasan & Lange (2007); Lange et al (2001)) is the first and, to this date, the only model of its kind. The model approximates the amount of liquid matter present in each lung generation, which, in conjunction with the local dosage provided by the deposition model, allows for the estimate of the local concentration of the inhaled drug.…”