In vitro aerodynamic characterization of the dose emitted during nebulization of tobramycin high strength solution by novel and jet nebulizer delivery systems

Abstract

The HSTS can be nebulized by all tested nebulisers but the high frequency NE-U22 Omron(®) and Aeroneb Go(®) are more efficient. When the HSTS compared to TOBI(®), the respirable inhaled dose was increased to more than 73%.

Reliability of Vibrating Mesh Technology

“…14 In addition, a recent report demonstrated variability from different manufacturers using the same dose of tobramycin. 15 It therefore remains uncertain whether mesh technology provides reproducible drug delivery for repeated use in a typical clinical trial. The primary objective of this study was to determine the reliability of the Aerogen Solo vibrating mesh nebulizer to repeatedly deliver the expected dose of a test aerosol.…”

Ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: understanding nebulization of aminoglycosides and colistin

“…There is evidence supporting the use of mesh ( Fig. 1a and b) rather than jet nebulizers for nebulized antibiotic delivery [1,3,11,15]. In vitro, mesh nebulizers appear superior over jet nebulizers to deliver tobramycin [15].…”

“…1a and b) rather than jet nebulizers for nebulized antibiotic delivery [1,3,11,15]. In vitro, mesh nebulizers appear superior over jet nebulizers to deliver tobramycin [15]. Aerosol particle size is slightly smaller with jet nebulizers compared to mesh nebulizers, but always remained below five microns, a condition required to reach the distal lung.…”

Innovation in Aerosol Drug Delivery During Adult Mechanical Ventilation

“…A limitation of this and other studies is its in vitro nature. [1][2][3][4][5][6][7]11 For some drugs with a flat dose-response curve, a more efficient device might not be better; for other drugs with a narrow therapeutic window, a low coefficient of variation will be of paramount importance for safety. The next step is to determine whether these differences in drug-delivery efficiency are clinically important.…”

“…The use of vibrating mesh nebulizers has been limited by poor performance with some formulations (eg, tobramycin and hypertonic saline) and reported problems with reliability. [4][5] There has been a paucity of technological development in the area of drug-delivery devices intended to be used with patients receiving mechanical ventilation. Cuccia et al 6 recently reported a new type of nebulizer that operates using a breath-enhancement mechanism and is placed before the inspiratory limb.…”