In vitro adsorption of various pharmaceuticals to montmorillonite

McGinity, James W.; Lach, John L.

doi:10.1002/jps.2600650623

Cited by 60 publications

(22 citation statements)

References 10 publications

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“…[7][8][9][10][11][12][13][14][15][16][17][18] In this study, we demonstrated that co-spray-drying of lactose and Na-MMT leads to lactose intercalation,…”

Section: Discussionmentioning

confidence: 99%

“…7-9, 12, 13, 19 Anionic and nonionic compounds have also been demonstrated to interact with MMT. 10,[15][16][17][18] In this study, lactose was chosen as a model nonionic organic substance and co-spray-dried with Na-MMT to form nanocomposites in with different host-guest ratios. Lactose is a hydrophilic low-molecular-weight compound (342.3 g/mol) and one of the most commonly used excipients in pharmaceutical drug delivery, food technology, and flavoring.…”

Section: Introductionmentioning

confidence: 99%

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Structure and Mobility of Lactose in Lactose/Sodium Montmorillonite Nanocomposites

et al. 2016

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This study aims at investigating the molecular level organization and molecular mobility in montmorillonite nanocomposites with the uncharged organic low-molecular-weight compound lactose commonly used in pharmaceutical drug delivery, food technology, and flavoring. Nanocomposites were prepared under slow and fast drying conditions, attained by drying at ambient conditions and by spray-drying, respectively. A detailed structural investigation was performed with modulated differential scanning calorimetry, powder X-ray diffraction, solidstate nuclear magnetic resonance, scanning electron microscopy, microcalorimetry, and molecular dynamic simulations. The lactose was intercalated in the sodium montmorillonite interlayer space regardless of the clay content, drying rate, or humidity exposure. Although, the spray-drying resulted in higher proportion of intercalated lactose compared with the drying under 2 ambient conditions, non-intercalated lactose was present at 20 wt% lactose content. This indicates limitations in maximum load capacity of nonionic organic substances into the montmorillonite interlayer space. Furthermore, a fraction of the intercalated lactose in the cospray-dried nanocomposites diffused out from the clay interlayer space upon humidity exposure.Also, the lactose in the nanocomposites demonstrated higher molecular mobility than that of neat amorphous lactose. This study provides a foundation for understanding functional properties of nanocomposites, such as loading capacity and physical stability.

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“…[7][8][9][10][11][12][13][14][15][16][17][18] In this study, we demonstrated that co-spray-drying of lactose and Na-MMT leads to lactose intercalation,…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structure and Mobility of Lactose in Lactose/Sodium Montmorillonite Nanocomposites

et al. 2016

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“…The adsorption phenomena, however, may change the physicochemical properties of the adsorbed products, and the suitability of some drugs for biological use can therefore be modified (Grim, 1962;Grim and Giiven, 1978). Thus, several studies have been carried out on the possible use of clays as a matrix in drug preparation (McGinity and Lach, 1976;Sfinchez-Martin et al, 1981;Sfinchez-Camazano et al, 1987). N-methyl 8-hydroxy quinoline methyl sulfate is a derivative of o-oxy quinoline and strongly absorbs erythematogenic near-ultraviolet radiation.…”

Section: Introductionmentioning

confidence: 99%

Adsorption and Desorption of N-Methyl 8-Hydroxy Quinoline Methyl Sulfate on Smectite and the Potential Use of The Clay-Organic Product as an Ultraviolet Radiation Collector

Vicente

1989

Clays and clay miner.

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Abstract--The interaction between N-methyl 8-hydroxy quinoline methyl sulfate, a drug that absorbs erymathogenic near-ultraviolet radiation, and smectite was studied by X-ray powder diffraction (XRD) and adsorption and desorption techniques. From the adsorption studies, (1) the amount of the drug adsorbed by Na-smectite increased with the pH of the solution to pH 6.5 and then decreased as the pH was further increased; (2) the maximum amount adsorbed at pH 6.5 was 102 meq/100 g of clay; and (3) the maximum amount of drug adsorbed, according to the adsorption isotherms at pH 4, was close to the cation-exchange capacity of the smectite (80 meq/100 g). The XRD studies showed that the drug molecules were adsorbed in the interlayer space of smectite and that cation exchange was the chief mechanism responsible for these interactions. The results of the adsorption-desorption cycles of the drug by smectite showed that this clay is a good support for this compound. In addition, an alternative method was developed to obtain the intercalation compound to avoid the standard method of exchange by impregnation. The method consisted of grinding a mixture of the drug with the clay. The characteristics of the complex thus formed were similar to those of the complex formed by exchange at pH 4 to 7.To gain insight into the pharmacological properties of the intercalation compound studied, its capacity for absorption of visible and near-ultraviolet light was investigated. The diffuse reflectance spectrum of the complex showed intense absorption bands, absent or weak in the spectra of the pure drug or the untreated clay, at 250, 290, and ~390 nm.Resumen--Se ha estudiado mediante difracci6n de rayos X (DRX) y t6cnicas de adsorci6n-desorci6n la interacci6n entre el metil-sulfato de N-metil 8-hidroxiquinolina, una droga que absorbe las radiaciones erimat6genas de la zona ultravioleta pr6xima, con la esmectita. A partir de los estudios de adsorci6n se ha encontrado que: (1) la cantidad de droga adsorbida por la esmectita s6dica aumenta con el pH hasta 6.5 y luego disminuye; (2) la mfixima cantidad adsorbida a pH 6.5 fue de 102 meq/100 g de arcilla; y (3) la cantidad mfixima adsorbida, seg6n los datos de la isoterma medida a pH 4, es similar a la capacidad de cambio de la esmectita (80 meq/100 g). Los estudios de DRX sefialan que las mol6culas de droga se adsorben en el espacio interlaminar de la esmectita y que el mecanismo principal de la interacci6n esmectita-droga es el cambio cati6nico. Los resultados de los estudios de ciclos de adsorci6n-desorci6n sefialan que esta arcilla es un buen soporte para este compuesto. Ademfis, se ha desarrollado un m&odo alternativo para obtener compuestos de intercalaci6n que evitan el m&odo convencional de intercambio por impregnaci6n. E1 m&odo consiste en la molienda de una mezcla de la droga y de la arcilla. Las caracteristicas del complejo asi formado son similares alas del complejo formado por intercambio a pH entre 4 y 7.Con objeto de profundizar en el conocimiento de las propiedades farmacol6gicas...

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“…Recent literature (9)(10)(11)(12) indicates that the thermal behavior of crystalline drugs is not well understood. The present study deals with the effects of hydration and specific surface area on the dissolution rate of erythromycin bulk drug (commercial mixture).…”

mentioning

confidence: 99%

Physical Characterization of Erythromycin: Anhydrate, Monohydrate, and Dihydrate Crystalline Solids

Allen

Rahn

Sarapu

et al. 1978

Journal of Pharmaceutical Sciences

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In vitro adsorption of various pharmaceuticals to montmorillonite

Cited by 60 publications

References 10 publications

Structure and Mobility of Lactose in Lactose/Sodium Montmorillonite Nanocomposites

Structure and Mobility of Lactose in Lactose/Sodium Montmorillonite Nanocomposites

Adsorption and Desorption of N-Methyl 8-Hydroxy Quinoline Methyl Sulfate on Smectite and the Potential Use of The Clay-Organic Product as an Ultraviolet Radiation Collector

Physical Characterization of Erythromycin: Anhydrate, Monohydrate, and Dihydrate Crystalline Solids

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