In vitro adsorption-desorption of famotidine on microcrystalline cellulose

Rivera, Sandra L.; Ghodbane, Samir

doi:10.1016/0378-5173(94)90413-8

Cited by 26 publications

(7 citation statements)

References 8 publications

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“…Studies of the adsorption of various drugs onto MCC suspended in aqueous solutions showed that adsorption of four phenothiazine derivatives was considerable and that of acrinol was quite large [ 43 ]. Other studies have reported adsorption of famotidine [ 44 ]. Furthermore, the disintegration of pellets based on MCC varies, depending on the type of MCC and on the wetting and drying conditions [ 45 ].…”

Section: Components Of S-seddsmentioning

confidence: 99%

Self-Emulsifying Granules and Pellets: Composition and Formation Mechanisms for Instant or Controlled Release

Nikolakakis

Partheniadis

2017

Pharmaceutics

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Many articles have been published in the last two decades demonstrating improvement in the dissolution and absorption of low solubility drugs when formulated into self-emulsifying drug delivery systems (SEDDS). Several such pharmaceutical products have appeared in the market for medium dose (Neoral® for Cyclsoprin A, Kaletra® for Lopinavir and Ritonavir), or low dose medications (Rocaltrol® for Calcitriol and Avodart® for Dutasteride). However, these are in the form of viscous liquids or semisolid presentations, characterized by the disadvantages of high production cost, stability problems and the requirement of large quantities of surfactants. Solid SEDDS (S-SEDDS), as coarse powders, granules or pellets, besides solubility improvement, can be filled easily into capsules or processed into tablets providing a handy dosage form with instant release, which can be further developed into controlled release by mixing with suitable polymers or coating with polymeric films. In this review, the materials used for the preparation of S-SEDDS, their properties and role in the formulations are detailed. Factors affecting the physical characteristics, mechanical properties of S-SEDDS as well as their in vitro release and in vivo absorption are discussed. The mechanisms involved in the formation of instant and sustained release self-emulsifying granules or pellets are elucidated. Relationships are demonstrated between the characteristics of S-SEDDS units (size, shape, mechanical properties, re-emulsification ability, drug migration and drug release) and the properties of the submicron emulsions used as massing liquids, with the aim to further elucidate the formation mechanisms. The influence of the composition of the powdered ingredients forming the granule or pellet on the properties of S-SEDDS is also examined. Examples of formulations of S-SEDDS that have been reported in the literature in the last thirteen years (2004–2017) are presented.

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Section: Components Of S-seddsmentioning

confidence: 99%

Self-Emulsifying Granules and Pellets: Composition and Formation Mechanisms for Instant or Controlled Release

Nikolakakis

Partheniadis

2017

Pharmaceutics

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“…Even though, the concentration of FF dissolved from all tablet formulations was slightly lower than that from spray-dried powder, the dissolution profile patterns were similar. The lower concentration of FF dissolved from tablet formulations might be due to the adsorption of FF by powder cellulose used in tablet (AlNimry et al, 1997;Okada et al, 1987;Rivera and Ghodbane, 1994). Furthermore, at first 30 min, the dissolution rate of FF in tablets was similar to spray-dried powder.…”

Section: Dissolutionmentioning

confidence: 90%

Preparation of fenofibrate dry emulsion and dry suspension using octenyl succinic anhydride starch as emulsifying agent and solid carrier

Pongsamart

Kleinebudde

Puttipipatkhachorn

2016

International Journal of Pharmaceutics

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“…The apigenin release from the uncoated layered pellets was immediate and completed within 5 minutes in distilled water and each dissolution media (pH=1.0, pH=6.8, pH=7.2) due to the water soluble binder material (HPMC). The apigenin release was complete therefore the possible occlusion by the porous surface of MCC cores can be excluded (Rivera et al, 1994).…”

Section: Dissolution Studiesmentioning

confidence: 99%

Development of oral site-specific pellets containing flavonoid extract with antioxidant activity

Pápay

Kállai-Szabó

Ludányi

et al. 2016

European Journal of Pharmaceutical Sciences

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Herbal medicines are recognized as an effective treatment of common diseases, mainly associated with oxidative stress. Therefore developing drug delivery systems of these biological active ingredients are gaining interest. Parsley (Petroselinum crispum L.) is a well-known culinary herb and its leaf contains high amount of apigenin, therefore it is suitable as a natural source of this flavonoid. Apigenin possess many health effects such as antioxidant, anti-inflammatory and anticancer activities. Unfortunately, these benefits are limited due to the low water solubility and bioavailability, it was recently classified as BCS II group compound. Therefore the aim of this study was to develop a carrier system for Petroselinum crispum extract, containing high amount of apigenin. Microcrystalline cellulose inert pellet cores were chosen and enteric coatings were applied. The produced multiparticulates had spherical shape, narrow size distribution and low moisture content. 10% (w/w) Eudragit® L 30 D-55 and 15% (w/w) Eudragit® FS 30 D coating was adequate for the modified release in vitro. The layered pellets demonstrated antioxidant activity. It was concluded that development of oral site-specific pellets containing flavonoid extract successful and the therapeutic effectiveness could be hypothesized.

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In vitro adsorption-desorption of famotidine on microcrystalline cellulose

Cited by 26 publications

References 8 publications

Self-Emulsifying Granules and Pellets: Composition and Formation Mechanisms for Instant or Controlled Release

Self-Emulsifying Granules and Pellets: Composition and Formation Mechanisms for Instant or Controlled Release

Preparation of fenofibrate dry emulsion and dry suspension using octenyl succinic anhydride starch as emulsifying agent and solid carrier

Development of oral site-specific pellets containing flavonoid extract with antioxidant activity

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