In vitro activity of Tridax procumbens against promastigotes of Leishmania mexicana

Martín-Quintal, Zhelmy; Moo-Puc, Rosa; González-Salazar, Francisco; Chan-Bacab, Manuel Jesús; Torres-Tapia, Luis W.; Peraza‐Sánchez, Sergio R.

doi:10.1016/j.jep.2009.01.037

Cited by 44 publications

(18 citation statements)

References 37 publications

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“…This result suggested that the antiamastigote activity of 1 is not due to activation of this leishmanicidal mechanism evolved by the macrophages, but may be due to the direct effect of 1 on the parasites. In this study, we report the biological activity of the metabolite (3S)-16,17-didehydrofalcarinol (1), isolated from T. procumbens, on the amastigote form of L. mexicana, with no effect upon mammalian cells, coinciding this result with those obtained against two cellular lines (MDCK and KB) and peripheral blood mononuclear human cells (PBMC) in which no cytotoxic activity was observed (Martín-Quintal et al, 2009). This effect represents an important advance in the search for novel antileishmanial agents from natural products, since a signifi cant activity against the intracellular stage (amastigote) of the protozoo was demonstrated.…”

Section: Resultssupporting

confidence: 63%

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The leishmanicidal effect of (3S)‐16,17‐didehydrofalcarinol, an oxylipin isolated from Tridax procumbens, is independent of NO production

Martín-Quintal

García-Miss

Mut-Martı́n

et al. 2010

Phytotherapy Research

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The in vitro leishmanicidal effect of (3S)-16,17-didehydrofalcarinol (1) isolated from Tridax procumbens whole plant against Leishmania mexicana, the causative agent of cutaneous leishmaniasis (chiclero's ulcer) in the New World, was investigated. This oxylipin showed significant in vitro activity against promastigotes and intracellular amastigotes of L. mexicana. Its inhibitory effect on amastigotes was not due to activation of NO in recombinant gamma-interferon-stimulated macrophages, since the production of NO was decreased in presence of the oxylipin. This is the first report on the leishmanicidal activity against the intracellular stage (amastigote) of the oxylipin (3S)-16,17-didehydrofalcarinol.

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Section: Resultssupporting

confidence: 63%

“…The bioactive natural product (1, Fig. 1) was purifi ed by chromatographic methods and characterized by RMN analyses, which have been described previously (Martín-Quintal et al, 2009). …”

Section: Methodsmentioning

confidence: 99%

The leishmanicidal effect of (3S)‐16,17‐didehydrofalcarinol, an oxylipin isolated from Tridax procumbens, is independent of NO production

Martín-Quintal

García-Miss

Mut-Martı́n

et al. 2010

Phytotherapy Research

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“…Tridax seemed to have anti-leishmanial activity when using crude extracts from the whole plant (Martín-Quintal et al, 2009). A study done in Ghana tested the antiplasmodial effect of aqueous, chloroform, ethyl acetate, and ethanolic extracts from the flowers, leaves, and stem of T. procumbens.…”

Section: Antiparasitic Activitymentioning

confidence: 99%

A Review of Medicinal Uses and Pharmacological Activities of Tridax Procumbens (L.)

Beck¹,

Mathison²,

Todorov³

et al. 2018

JPS

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Tridax procumbens is a very promising species that produces secondary metabolites reported to have a variety of medicinal uses including among others, anti-anemic, anti-inflammatory, anti-diabetic and anesthetic properties. This species has a long history of traditional use by different communities. This study aimed to review the scientific literature regarding the medicinal properties, biological activity and phytochemical components of T. procumbens, a member of the Asteraceae family that originated in Central and South America. An extensive literature review was done using Metadatabase EDS, MedLine (PubMed), Science Direct, Web of Science, Academic Search Premier, Scielo, DOAJ Directory of Open Access Journals, JSTOR, and other sources to find information relevant to the medicinal uses of T. procumbens. At total of 130 studies were found that contained information about T. procumbens. Some of the papers were not included because of the relevance to this study, ending with a total of 111 relevant citations reported here. This review shows the importance of more studies to understand the potential of T. procumbens' secondary metabolites for medicinal or preventive treatment, making it a promising ethnobotanical resource. This review provides important information of this species and indicates that this species could be an effective, safe and affordable treatment for some ailments, especially in tropical areas where this plant is native and widely distributed.

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“…Furthermore, they showed that B. vulgaris displayed effective in vitro leishmanicidal properties against L. tropica and L. infantum by the MTT assay (13). In vitro studies on activity of Tridax procumbens extracts against promastigotes of Leishmania Mexicana showed potent activity with no effect on mammalian cells (14). In vitro anti-leishmanial activity of Urechites andrieuxii (Apocynaceae) was evaluated and a significant effect was reported (15).…”

Section: In Vitro Study Of Herbal Drugsmentioning

confidence: 99%

Herbal Drugs with Promising Anti-Leishmanial Activity: New Hope for Leishmaniasis Treatment

et al. 2016

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Context: Leishmaniasis is one of the most common parasitic diseases. Many medicinal plants have been utilized for the treatment of leishmaniasis. Evidence Acquisition: Recent clinical trials have proven the efficacy of a number of herbal drugs. Synthetic agents and current drugs on the market have some disadvantages, such as side effects, high cost, and painful injections. Given the efficiency of herbal drugs, they can be a source of natural and harmless compounds for Leishmania treatment. Results: Several researches have shown a wide range of plant extract exhibiting remarkable anti-leishmanial activity in vitro and in vivo. Conclusions: Attempts for discovery of an effective strategy for leishmaniasis treatment with nominal side effects are being continued and herbal drugs are receiving much interest. More clinical studies should be done to investigate the efficacy and safety of herbal drugs for the production of effective and safe drugs for leishmaniasis treatment. This may also provide new hope for leishmaniasis treatment.

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In vitro activity of Tridax procumbens against promastigotes of Leishmania mexicana

Cited by 44 publications

References 37 publications

The leishmanicidal effect of (3S)‐16,17‐didehydrofalcarinol, an oxylipin isolated from Tridax procumbens, is independent of NO production

The leishmanicidal effect of (3S)‐16,17‐didehydrofalcarinol, an oxylipin isolated from Tridax procumbens, is independent of NO production

A Review of Medicinal Uses and Pharmacological Activities of Tridax Procumbens (L.)

Herbal Drugs with Promising Anti-Leishmanial Activity: New Hope for Leishmaniasis Treatment

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