In vitro activity of the new ketolide ABT-773 against community acquired respiratory tract isolates and Viridans Streptococci

Casellas, José María; Tomé, Gabriella; Visser, Maaike; Gliosca, Laura

doi:10.1016/s0732-8893(01)00323-6

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…Studies of time-kill curves with cethromycin and telithromycin at 24 h demonstrated that these ketolides are predominantly bacteriostatic and only slowly bactericidal at higher concentrations. 28,29 Perhaps 3 h of incubation is too short a period to demonstrate any bactericidal activity with a bacteriostatic antimicrobial agent such as cethromycin.…”

Section: Discussionmentioning

confidence: 99%

Accumulation and activity of cethromycin (ABT-773) within human polymorphonuclear leucocytes

Garcı́a

Pascual²,

Ballesta³

et al. 2003

Journal of Antimicrobial Chemotherapy

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Section: Discussionmentioning

confidence: 99%

Accumulation and activity of cethromycin (ABT-773) within human polymorphonuclear leucocytes

Garcı́a

Pascual²,

Ballesta³

et al. 2003

Journal of Antimicrobial Chemotherapy

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Acute Exacerbations of Chronic Bronchitis

2006

Wiley Handbook of Current and Emerging Drug Therapies

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Community‐Acquired Pneumonia

2006

Wiley Handbook of Current and Emerging Drug Therapies

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Five hundred ninety patients were enrolled in a prospective, multicenter, randomized trial comparing the efficacy and safety of 7 to 14 days of levofloxacin treatment with that of ceftriaxone and/or cefuroxime axetil in the management of community-acquired pneumonia in adults. Patients received either intravenous and/or oral levofloxacin (500 mg once daily) or the comparative agents, parenteral ceftriaxone (1 to 2 g once to twice daily) and/or oral cefuroxime axetil (500 mg twice daily). Erythromycin or doxycycline could be added to the comparator arm at the investigator's discretion. The decision to use an intravenous or oral antimicrobial agent for initial therapy was made by the investigator. Clinical and microbiological evaluations were completed at the baseline, during treatment, 5 to 7 days posttherapy, and 3 to 4 weeks posttherapy. Four hundred fifty-six patients (226 given levofloxacin and 230 administered ceftriaxone and/or cefuroxime axetil) were evaluable for clinical efficacy. Streptococcus pneumoniae and Haemophilus influenzae were isolated in 15 and 12%, respectively, of clinically evaluable patients. One hundred fifty atypical pathogens were identified: 101 were Chlamydia pneumoniae, 41 were Mycoplasma pneumoniae, and 8 were Legionella pneumophila. Clinical success at 5 to 7 days posttherapy was superior for the levofloxacin group (96%) compared with the ceftriaxone and/or cefuroxime axetil group (90%) (95% confidence interval [CI] of ؊10.7 to ؊1.3). Among patients with typical respiratory pathogens who were evaluable for microbiological efficacy, the overall bacteriologic eradication rates were superior for levofloxacin (98%) compared with the ceftriaxone and/or cefuroxime axetil group (85%) (95% CI of ؊21.6 to ؊4.8). Levofloxacin eradicated 100% of the most frequently reported respiratory pathogens (i.e., H. influenzae and S. pneumoniae) and provided a >98% clinical success rate in patients with atypical pathogens. Both levofloxacin and ceftriaxone-cefuroxime axetil eradicated 100% of the S. pneumoniae cells detected in blood culture. Drug-related adverse events were reported in 5.8% of patients receiving levofloxacin and in 8.5% of patients administered ceftriaxone and/or cefuroxime axetil. Gastrointestinal and central and peripheral nervous system adverse events were the most common events reported in each treatment group. In conclusion, these results demonstrate that treatment with levofloxacin is superior to ceftriaxone and/or cefuroxime axetil therapy in the management of community-acquired pneumonia in adults.

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In vitro activity of the new ketolide ABT-773 against community acquired respiratory tract isolates and Viridans Streptococci

Cited by 5 publications

References 12 publications

Accumulation and activity of cethromycin (ABT-773) within human polymorphonuclear leucocytes

Accumulation and activity of cethromycin (ABT-773) within human polymorphonuclear leucocytes

Acute Exacerbations of Chronic Bronchitis

Community‐Acquired Pneumonia

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