In vitro activity of telithromycin (HMR 3647) and seven other antimicrobial agents against anaerobic bacteria

Abstract

We assessed the in vitro activity of telithromycin (HMR 3647) and seven other antimicrobials against 292 strains of obligately anaerobic bacteria. MICs were determined with the microdilution technique and Wilkins-Chalgren broth according to DIN 58940-83. MIC50/MIC90s (mg/L) for telithromycin were 4/4 for Bacteroides fragilis, Bacteroides ovatus and Bacteroides thetaiotaomicron, 2/4 for Fusobacterium spp. and Bilophila wadsworthia, 2/2 for Bacteroides caccae, 1/4 for Bacteroides vulgatus, 0.25/4 for Prevotella spp., > or =0.03/0.5 for Clostridium spp. and 0.125/4 for Peptostreptococcus spp.

Telithromycin: An Oral Ketolide for Respiratory Infections

“…46,57,59,62 In contrast, MICs were elevated against other anaerobes, including most strains of Clostridium sp, Fusobacterium sp, and Bacteroides sp. 57,59,61 Mycobacteria Telithromycin has variable activity against rapidly growing mycobacteria with an MIC 90 of 4 µg/ml against 25 isolates of Mycobacterium chelonei and 1 µg/ml against 12 isolates of M. peregrinum. 68 High MICs (> 64 µg/ml) were observed with 48 isolates of M. fortuitum.…”