In vitro activity of Peltophorum africanum Sond. (Fabaceae) extracts on the egg hatching and larval development of the parasitic nematode Trichostrongylus colubriformis

Bizimenyera, E.S.; Githiori, J. B.; Eloff, Jacobus Nicolaas; Swan, Gerry E.

doi:10.1016/j.vetpar.2006.06.013

Cited by 126 publications

(107 citation statements)

References 26 publications

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“…Substances produced from plants may represent an alternative for controlling gastrointestinal nematodes, since they have the advantage of sustainable supply and are ecologically acceptable (COSTA et al, 2008). The use of medicinal plants has been reported in treating various ailments, thereby increasing the interest in ethnomedical and ethnoveterinary cures (BIZIMENYERA et al, 2006). Rev.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Eucalyptus citriodora essential oil on goat gastrointestinal nematodes

Macedo

Beviláqua

Oliveira

et al. 2011

Rev. Bras. Parasitol. Vet.

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Phytotherapy may be an alternative strategy for controlling gastrointestinal parasites. This study evaluated the anthelmintic efficacy of Eucalyptus citriodora essential oil (EcEO). The in vitro effects of EcEO were determined through testing the inhibition of egg hatching and larval development of Haemonchus contortus. EcEO was subjected to acute toxicity testing on mice, orally and intraperitoneally. The in vivo effects of EcEO were determined by the fecal egg count reduction test (FECRT)

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Section: Introductionmentioning

confidence: 99%

Evaluation of Eucalyptus citriodora essential oil on goat gastrointestinal nematodes

Macedo

Beviláqua

Oliveira

et al. 2011

Rev. Bras. Parasitol. Vet.

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“…However, all the concentrations showed inhibition above 93.0%, while in control groups there was no larvae inhibition during the first 24 hours Among the extraction methods evaluated, EAM presented as an efficient and affordable alternative to be used in helminthes control. The preparation of medicinal species in water is a commonly used practice in folk medicine and its use as a natural vermifuge is becoming more popular as an alternative method, sustainable and adaptable for rural communities (Alawa et al, 2003;Fonseca et al, 2005;Bizimenyera et al, 2006). However, aiming to obtain a formulation for large-scale industrial production, lyophilized extract is presented as a more acceptable formulation because it provides greater physical, chemical and microbial stability, and facilitates homogenization and standardization of the active ingredients (Runha et al, 2001;Chaicouski et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

Anthelmintic potential and in vivo acute toxicity study of Piptadenia gonoachanta leaf aqueous extract

2017

J App Pharm Sci

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Piptadenia gonoacantha (Leguminosae) is an arboreal species found in southern and southeastern Brazil. Several compounds have been identified in their leaves, such as anthraquinones, phenolics, tannins, saponins, coumarins and flavonoids. The presence of these metabolites is associated with antioxidant, anti-inflammatory, antibiotic and anthelmintic properties. This study evaluated the phytochemical profile of in vitro anthelmintic activity and in vivo toxicity of the aqueous extract of P. gonoacantha leaves. The extracts were distinctly evaluated by extraction method: maceration (EAM), ultrasonication (EAU) and lyophilization (EAL). Anthelmintic activity analysis was carried out for all preparations at 25, 50 and 100 mg.mL -1 against Panagrellus sp. in an in vitro assay. In vivo toxicity was assessed by biochemical, hematological and histological evaluation of Balb/C mice treated orally with EAU (100, 200 and 400 mg.Kg -1 ) for 10 consecutive days. Phytochemical analysis showed the presence of tannins, flavonoids, coumarins, saponins, glycosides, phenolic compounds and anthraquinone. Anthelmintic potential showed significant results, with inhibition potential ranging from 93.93% and 99.88% among the different concentrations and preparations tested. In absolute values, the EAPG at 50 mg / mL showed a higher percentage of inhibition, reaching the following concentrations: 25, 50 and 100 mg / mL of preparation I (EAM), 25 and 100 mg / mL of preparation II (EAU) and 25 , 50 and 100 mg / mL of preparation III (EAL), had percentage of inhibition of 99.39%, 96.15%, 96.57%, 96.45%, 95.01%, 99.74% and 99% 44% respectively. EAU has proved to be safe for in vivo use because it showed low toxicity, enabling it to future pre-clinical and clinical studies.

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“…Egg recovery and preparation was based on the procedure described by Bizimenyera et al (2006). Faeces were collected from lambs with monospecific infections of T.…”

Section: Egg Preparationmentioning

confidence: 99%

“…Plant extracts may simultaneously have high anthelmintic activities and high non-selective cytotoxic activities. Results from numerous studies suggest that tannin components in plant extracts have anthelmintic and cytotoxic activities (Takechi et al, 1985;Bizimenyera et al, 2006;Jiang et al 2008;Ramalingam et al, 2010). Tannins have been linked to a case of poisoning in avian species (Kinde, 1988).…”

Section: Introductionmentioning

confidence: 99%

Anthelmintic and cytotoxic activities of extracts of Markhamia obtusifolia Sprague (Bignoniaceae)

Nchu¹,

Githiori²,

McGaw³

et al. 2011

Veterinary Parasitology

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The anthelmintic activity of Markhamia obtusifolia Sprague (Bignoniaceae) leaf extracts was evaluated against the ruminant gastrointestinal nematode parasite Trichostrongylus colubriformis (Nematoda: Strongylida) using the in vitro egg hatch test. Also, the cytotoxic activity of aqueous extracts of M. obtusifolia was evaluated in cell line cytotoxicity assays. The results indicated that the effective concentration (EC 50 ) for the water extract of M. obtusifolia leaves (0.46 mg/mL; Confidence Interval[CI] 0.3-0.5 mg/mL) was significantly lower than the EC 50 for the acetone extract of M. obtusifolia (0.8 mg/mL; CI 0.7-1 mg/mL). Aqueous extracts were twice as potent as the acetone extracts. The ED 90 (0.2 mg/mL; CI 0.1-0.02) for thiabendazole (positive control) was significantly lower than the EC 90 for the water extract of M. obtusifolia 2 (10.7 mg/mL; CI 8.3-13.7 mg/mL). In the cytotoxicity bioassay, the lethal concentration (LC 50 ) for the aqueous extract of M. obtusifolia was 0.476 mg/mL, which was relatively high (low toxicity) in comparison to the highly toxic berberine (LC 50 = 9.80 µg/mL). The current study showed that M. obtusifolia plant extracts possess anthelmintic activity and are relatively non-cytotoxic, thus providing support for their use in traditional veterinary practices.

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In vitro activity of Peltophorum africanum Sond. (Fabaceae) extracts on the egg hatching and larval development of the parasitic nematode Trichostrongylus colubriformis

Cited by 126 publications

References 26 publications

Evaluation of Eucalyptus citriodora essential oil on goat gastrointestinal nematodes

Evaluation of Eucalyptus citriodora essential oil on goat gastrointestinal nematodes

Anthelmintic potential and in vivo acute toxicity study of Piptadenia gonoachanta leaf aqueous extract

Anthelmintic and cytotoxic activities of extracts of Markhamia obtusifolia Sprague (Bignoniaceae)

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