In vitro activity of macrolides and lincosamides against oral streptococci: a therapeutic alternative in prophylaxis for infective endocarditis

Liébana, J; Parejo, Eva Aguilera; Castillo, Ana; Gutiérrez, J; García-Mendoza, A.; Piédrola, G

doi:10.1016/0924-8579(93)90059-e

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…Streptococci possess superoxide dismutase, and many strains are known to produce H # O # . There have been many studies on H # O # production by oral streptococci (Garcia-Mendoza et al, 1993 ;Holmberg & Hallander, 1973 ;LeBien & Bromel, 1975 ;Liebana et al, 1993 ;Willcox & Drucker, 1988), and this characteristic has often been important for the classification of these species (McLeod & Gordon, 1922 ;Whiley et al, 1990). However, there are few reports on H # O # production by S. pyogenes (Gibson et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

H2O2-nonproducing Streptococcus pyogenes strains: survival in stationary phase and virulence in chronic granulomatous disease

et al. 2001

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The production of hydrogen peroxide (H 2 O 2 ) and related phenotypes were studied with Streptococcus pyogenes strains isolated from cases of pharyngitis or severe group A streptococcal infections. Of the 46 strains examined (34 from severe infections and 12 from pharyngitis cases), 25 strains accumulated H 2 O 2 in the culture medium when grown under glucose-limited, aerobic conditions, whereas the rest of the strains did not. There was no correlation between these traits and the type of disease from which each strain had been isolated. The H 2 O 2 -nonproducing strains tested in this study belonged to T type 3 or T type 12. The accumulation of H 2 O 2 started when the culture reached the late exponential phase. A rapid loss of cell viability accompanied H 2 O 2 accumulation but was completely prevented by the addition of a catalase, indicating that the lethality was actually caused by H 2 O 2 . Cells of H 2 O 2 -nonproducing strains were resistant to killing by phagocytes from patients with chronic granulomatous disease (CGD), whereas those of H 2 O 2 -producing strains were subject to killing. Subcutaneous inoculation of 10 5 c.f.u. H 2 O 2 -nonproducing S. pyogenes strains into the hind footpads of CGD mice provoked more prominent swelling of the footpad than did H 2 O 2 -producing strains. The mortality rate in the CGD mice infected with the H 2 O 2 -nonproducing strains was higher than that produced by the H 2 O 2 -producing strains. It is suggested that H 2 O 2 -nonproducing S. pyogenes strains are prevalent in humans and that they may be a potential threat to the health of CGD patients.

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Section: Introductionmentioning

confidence: 99%

H2O2-nonproducing Streptococcus pyogenes strains: survival in stationary phase and virulence in chronic granulomatous disease

et al. 2001

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“…Streptococcus mutans is a microorganism that may be involved in localized disease such as dental caries [1–5], systemic infections resulting from dental interventions, or bacteremia. In some patients with predisposing factors, S. mutans can lead to subacute endocarditis [6–8]; in rare cases it has been associated with other severe infectious diseases [9]. Since the appearance of Keyes's study in 1960 [10], several studies have confirmed that S. mutans is transmissible [11–13].…”

Section: Introductionmentioning

confidence: 99%

A new biotyping method for Streptococcus mutans with the API ZYM system

Higuera

Gutiérrez

Liébana

et al. 1999

Clinical Microbiology and Infection

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OBJECTIVE: To test a new system for the biotyping of Streptococcus mutans, based on the measurement of enzyme activity, and to investigate the relationship between biotype and in vitro susceptibility to seven clinically useful antibiotics. METHODS: In total, 160 oral isolates of S. mutans were classified into different biotypes with the APIZYM test for enzyme activity, excluding results that were positive or negative in >80% of the strains. The susceptibility of all 160 strains to amoxycillin, cefazolin, erythromycin, clindamycin, vancomycin, teicoplanin and imipenem was tested by dilution in a solid medium. Statistical analysis of susceptibility (mean minimum inhibitory concentrations (MICs)) was based on chi-squared tests. RESULTS: Eight different biotypes (1-8) were identified on the basis of three kinds of enzyme activity: valine aryl amidase, acid phosphatase and alpha-galactosidase. Biotype 5 was found to be the most common. The mean MIC values showed strains belonging to biotype 4 to be the most susceptible to amoxycillin, cefazolin and erythromycin, whereas biotype 1 was the least susceptible to teicoplanin. CONCLUSIONS: The proposed biotyping method, which is relatively fast and simple to perform, provided reproducible results, and may contribute to clinically effective treatment of S. mutans infections.

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Anodic polarographic determination of josamycin in formulations and spiked human urine

et al. 2004

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In vitro activity of macrolides and lincosamides against oral streptococci: a therapeutic alternative in prophylaxis for infective endocarditis

Cited by 5 publications

References 26 publications

H2O2-nonproducing Streptococcus pyogenes strains: survival in stationary phase and virulence in chronic granulomatous disease

H2O2-nonproducing Streptococcus pyogenes strains: survival in stationary phase and virulence in chronic granulomatous disease

A new biotyping method for Streptococcus mutans with the API ZYM system

Anodic polarographic determination of josamycin in formulations and spiked human urine

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