In vitro activity of FR193879, a novel anti-Helico-bacter pylori cephalosporin

Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi

“…450 It was used in Japan in the 1980s for the treatment of non-specific or traveler's diarrhea, and is still used in livestock for the treatment and eradication of verotoxin-producing E. coli . 4,5 In in vitro assays it could be demonstrated that BCM participates in bacteriostatic synergy and exhibits lethal synergy against Gram-negative bacteria ( E. coli , A. baumanii , K. pneumoniae , Salmonella enterica serotype Typhimurium, and Shigella dysenteriae ) when it is coadministered with known, bacteriostatic inhibitors of gene expression ( e.g. Rif, chloramphenicol, and tetracycline).…”

“…3 In addition to that, the commercially available bicyclomycin (inhibitor of transcription factor r) was used in Japan in the 1980s for the treatment of traveler's diarrhea and is currently in use for the treatment and eradication of verotoxin-producing Escherichia coli (E. coli) in livestock. 4,5 In general, there are two different approaches for targeting RNAP: rst, direct inhibition of RNAP subunits, and second, inhibition of protein-protein-interactions (PPI) of RNAP subunits with essential factorsan emerging antibacterial drug target. 6 In recent decades, however, human society has experienced that the medical potential of antibiotics is at signicant risk -largely through incorrect or overuse of these compounds.…”