In vitro activity of a partially purified and characterized bark extract of<i>Castanea sativa Mill</i>. (ENC®) against<i>Chlamydia</i>spp

Papa, Valentina; Ginocchietti, Laura; Budriesi, Roberta; Micucci, Matteo; Costa, Roberta; Biondi, Roberta; Cevenini, Roberto; Chiarini, Alberto; Aldini, Rita; Donati, Manuela; Pollini, Gian Matteo; Cenacchi, Giovanna

doi:10.1080/01913123.2016.1275909

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…Papa et al demonstrated that CSWE reduced all Chlamydia strains tested at 1 µg/mL, while SMAP-29 at 10 µg/mL caused a reduction in the infectivity of C. trachomatis and C. pneumoniae. A strong reduction in the infectivity of C. trachomatis, C. pneumoniae, and C. abortus was achieved with a CSWE concentration of 10 µg/mL, while their infectivity was almost inhibited at a CSWE concentration of 100 µg/mL [68]. The study by Brizi et al investigated the neuroprotective effect of CSWE in in vitro models of oxidative stress injury.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Beneficial Effects of Castanea sativa Wood Extract on the Human Body and Possible Food and Pharmaceutical Applications

Žitek Makoter,

Tancer Verboten,

Mirt

et al. 2024

Plants

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The aim of this review was to investigate the potential use of Castanea sativa wood extract as a food supplement and to evaluate its beneficial properties for human health. The results of the limited amount of studies suggest promising properties, including potential anti-inflammatory effects. The literature indicates that the extract, which is rich in bioactive compounds such as tannins, offers promising therapeutic possibilities for the treatment of conditions associated with chronic inflammation. Consequently, interest in its use in food and pharmaceuticals is growing. Phytochemical studies have reported antioxidant and antimicrobial activities, and anti-inflammatory, anticancer, hypolipidemic, hypoglycemic, and neuroprotective activities. A suitable extraction method and solvent is crucial for the isolation of bioactive compounds, being green extraction technologies outstanding for the industrial recovery of chestnut wood’s bioactive compounds. Nevertheless, it is important to emphasize the importance of adhering to regulatory guidelines and obtaining the necessary approvals from regulatory authorities to ensure product safety and compliance. The regulation of herbal medicinal products with proven efficacy and traditional herbal medicinal products is well defined, monitored by authorized bodies, and subject to strict control measures. It is noteworthy that medicinal products are subject to stringent quality testing to ensure safety and efficacy in use, whereas there are no comparable regulatory standards and specific labeling requirements for dietary supplements. When using herbal products, compliance with established standards in health research is essential.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Beneficial Effects of Castanea sativa Wood Extract on the Human Body and Possible Food and Pharmaceutical Applications

Žitek Makoter,

Tancer Verboten,

Mirt

et al. 2024

Plants

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“…The emergence of antibiotic resistance should be the driver for development and application of new antichlamydials in veterinary medicine. Efforts for these are already underway, including in animals (Lawrence et al, 2016), exploiting a range of strategies to target Chlamydia -specific cell structures and/or known virulence factors (Ur-Rehman et al, 2012; Marti et al, 2014; Koroleva et al, 2015; Rahn et al, 2016; Donati et al, 2017; Papa et al, 2017; Figure 1). Regardless of years of research into chlamydia control through immunoprophylaxis there are almost no viable chlamydial vaccines to date.…”

Section: Future Directions and Concluding Remarksmentioning

confidence: 99%

Mini Review: Antimicrobial Control of Chlamydial Infections in Animals: Current Practices and Issues

Bommana

2019

Front. Microbiol.

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Chlamydia are a genus of successful obligate intracellular pathogens spread across humans, wildlife, and domesticated animals. The most common species reported in livestock in this genus are Chlamydia abortus, Chlamydia psittaci, Chlamydia suis, and Chlamydia pecorum. Chlamydial infections trigger a series of inflammatory disease-related sequelae including arthritis, conjunctivitis, pneumonia, and abortion. Other bacteria in the phylum Chlamydiae have also been reported in livestock and wildlife but their impact on animal health is less clear. Control of chlamydial infections relies on the use of macrolides, fluoroquinolones, and tetracyclines. Tetracycline resistance (TETR) reported for porcine C. suis strains in association with the use of tetracycline feed is a potentially significant concern given experimental evidence highlighting that the genetic elements inferring TETR may be horizontally transferred to other chlamydial species. As documented in human Chlamydia trachomatis infections, relapse of infections, bacterial shedding post-antibiotic treatment, and disease progression despite chlamydial clearance in animals have also been reported. The identification of novel chlamydiae as well as new animal hosts for previously described chlamydial pathogens should place a renewed emphasis on basic in vivo studies to demonstrate the efficacy of existing and new antimicrobial treatment regimes. Building on recent reviews of antimicrobials limited to C. trachomatis and C. suis, this review will explore the use of antimicrobials, the evidence and factors that influence the treatment failure of chlamydial infections in animals and the future directions in the control of these important veterinary pathogens.

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In vitro activity of a partially purified and characterized bark extract ofCastanea sativa Mill. (ENC®) againstChlamydiaspp

Cited by 2 publications

References 35 publications

Beneficial Effects of Castanea sativa Wood Extract on the Human Body and Possible Food and Pharmaceutical Applications

Beneficial Effects of Castanea sativa Wood Extract on the Human Body and Possible Food and Pharmaceutical Applications

Mini Review: Antimicrobial Control of Chlamydial Infections in Animals: Current Practices and Issues

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