In vitro activity of 19 antimicrobial agents against 3513 nosocomial pathogens collected from 48 Canadian medical centres

Blondeau, Joseph M; Vaughan, David

doi:10.1016/s0924-8579(00)00170-9

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…It has a broad spectrum of activity and in human medicine it is used basically at hospitals for treatment of multiresistant bacteria. Most CPS isolated from humans are susceptible to imipenem (Blondeau and Vaughan, 2000). To our knowledge, this antibiotic is not used in veterinary medicine in our area, but some studies (Piriz et al, 1995) have reported a high percentage of imipenem resistant S. intermedius.…”

Section: Discussionmentioning

confidence: 97%

Identification and Antimicrobial Susceptibility of Coagulase Positive Staphylococci Isolated from Healthy Dogs and Dogs Suffering from Otitis Externa

Tejedor-Junco

Barrasa

2002

Journal of Veterinary Medicine, Series B

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A total of 67 strains of coagulase positive staphylococci isolated from healthy dogs and dogs suffering from otitis externa were studied. Twenty-two isolates were from healthy dogs (five from hound dogs and 17 from companion dogs) and 45 from dogs suffering otitis externa (14 from hound dogs and 31 from companion dogs). Presumptive identification was attempted using the following tests: production of acetoin, anaerobic utilization of mannitol, acid production from mannitol, presence of beta-galactosidase, and growth on P agar supplemented with different concentrations of acriflavine. Susceptibility of staphylococci to 16 antibiotics was determined. Most effective antibiotics were imipenem, amoxycillin/clavulanic acid, ciprofloxacin, tobramycin, gentamicin and marbofloxacin. Penicillin, ampicillin and polymyxin B showed the lowest activity. There were no significant differences in antimicrobial susceptibility among isolates from healthy dogs and dogs suffering from otitis externa.

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Section: Discussionmentioning

confidence: 97%

Identification and Antimicrobial Susceptibility of Coagulase Positive Staphylococci Isolated from Healthy Dogs and Dogs Suffering from Otitis Externa

Tejedor-Junco

Barrasa

2002

Journal of Veterinary Medicine, Series B

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“…Antimicrobial-resistant bacteria carried by animals can enter the human food chain through the consumption of meat or other animal products, through farm runoff water, and by other pathways (Donnelly, 1999). It has now become clear that antimicrobial resistance poses a threat to human and animal health and should be taken seriously (Blondeau and Vaughan, 2000;Mora et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Resistance patterns and detection of resistance genes in Escherichia coli isolated from diarrheic calves in Northeastern China

Jiang¹,

Zhang²

2013

Afr. J. Microbiol. Res.

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The aim of this study was to investigate the antimicrobial resistance and to characterize the implicated genes in Escherichia coli isolated from diarrheic calves during 2008-2011. A total of 104 samples were tested to 15 antimicrobial agents with disk-diffusion method. High resistance to amoxicillin, streptomycin, tetracycline, trimethoprim-sulfamethoxazole and doxycycline was detected. A total of 13 out of the 16 resistance genes were searched in this study. The principal mechanisms of resistance found in the 104 calf isolates were blaTEM (84.6%), aadA1(73.3%), cmlA(46.2%), tet(B)(79.8%), sulI (74.0%) and dhfrV(54.8%). One kind of amino acid change in gyrA (four Ser83→Leu) and sixteen in parC (twelve 80Ser→Arg, four 80Ser→Ile) were identified in the 20 fluoroquinolone-resistant isolates. According to pulsed field gel electrophoresis (PFGE) results, clonal dissemination of multi-drug resistance (MDR) strains played an important role in the severe resistant situation among diarrheic neonatal calves in northeastern China.

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“…Controlling antimicrobial resistance can help maintain antibiotic usage, stabilize costs associated with the use of ever more potent drugs and allow treatment of increasingly resistant infections [4]. Though several factors contribute to the spread and emergence of drug-resistant bacteria, their effect on the spread and expression of resistance cannot be predicted [5].…”

Section: Introductionmentioning

confidence: 99%

Comparative in vitro Activity of Three Fluoroquinolones against Clinical Isolates by E Test

et al. 2003

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The in vitro susceptibility of levofloxacin, ciprofloxacin and moxifloxacin against several gram-positive and gram-negative clinical isolates was tested by E test. We found that the MIC₅₀ and MIC₉₀ values against all members of the Enterobacteriaceae family except Serratia were <0.5 mg/l for ciprofloxacin and levofloxacin (MIC range 0.006–32 mg/l) based on the in vitro susceptibility data. The susceptibility rates for ciprofloxacin and levofloxacin were more than 85% for Escherichia coli, Citrobacter, Enterobacter cloacae, Enterobacter aerogenes and Klebsiella pneumoniae, although Serratia and Acinetobacter exhibited more or less similar susceptibility rates (about 80%). Pseudomonas aeruginosa demonstrated significant resistance to fluoroquinolones (MIC₉₀ >32 mg/l) and decreased bactericidal rates (<65%) to levofloxacin and ciprofloxacin. Respiratory pathogens such as Streptococcus pneumoniae and Haemophilus influenzae were highly susceptible (100%) to levofloxacin and moxifloxacin. The ineffectiveness of fluoroquinolones for treating coagulase-positive Staphylococcus aureus was demonstrated by poor in vitro susceptibility rates with levofloxacin (52%) and moxifloxacin (57%). Coagulase-negative staphylococci demonstrated significantly decreased bactericidal rates to levofloxacin (21%), while the in vitro susceptibility to moxifloxacin was higher (66%) than that to levofloxacin. We propose that the beneficial effect of inclusion of any of these three fluoroquinolones in treating Enterococcus infections is marginal, as demonstrated by significantly reduced susceptibility rates (<32%). These data demonstrate the utility of fluoroquinoles to treat several gram-negative bacterial infections (with the exception of Acinetobacter and P. aeruginosa), as well as S. pneumoniae and H. influenzae.

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In vitro activity of 19 antimicrobial agents against 3513 nosocomial pathogens collected from 48 Canadian medical centres

Cited by 9 publications

References 14 publications

Identification and Antimicrobial Susceptibility of Coagulase Positive Staphylococci Isolated from Healthy Dogs and Dogs Suffering from Otitis Externa

Identification and Antimicrobial Susceptibility of Coagulase Positive Staphylococci Isolated from Healthy Dogs and Dogs Suffering from Otitis Externa

Resistance patterns and detection of resistance genes in Escherichia coli isolated from diarrheic calves in Northeastern China

Comparative in vitro Activity of Three Fluoroquinolones against Clinical Isolates by E Test

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