In vitro activities of lomefloxacin, tetracycline, penicillin, spectinomycin, and ceftriaxone against Neisseria gonorrhoeae and Chlamydia trachomatis

Talbot, H; Romanowski, Barbara

doi:10.1128/aac.33.12.2049

Cited by 10 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fractional inhibitory concentration (FIC) index for combinations was calculated as follows (11): Ridit analysis illustrates the relative position of the score of a particular group against an identified distribution of a reference group (20). The analysis was carried out by the calculation function of Excel Table. In each batch of microdilution tests, the MICs of the five antimicrobial agents for strains VR-348B and L3 all fell within the ranges previously observed by other investigators using the same method (10,15,22). The ranges of MICs of spectinomycin, ceftriaxone, erythromycin, ofloxacin, and doxycycline were 128 to 256, 10 to 20, 0.06 to 0.5, 0.25 to 1, and 0.015 to ϳ0.125 g/ml, respectively, in our study.…”

supporting

confidence: 56%

In Vitro Effects of Spectinomycin and Ceftriaxone Alone or in Combination with Other Antibiotics against Chlamydia trachomatis

Shang

Xia

Zhong

et al. 2005

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

supporting

confidence: 56%

In Vitro Effects of Spectinomycin and Ceftriaxone Alone or in Combination with Other Antibiotics against Chlamydia trachomatis

Shang

Xia

Zhong

et al. 2005

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…Ceftriaxone has also been found to be active against Legionella spp. culture medium, aberrant chlamydial inclusions were formed rather than chlamydial inclusions disappearing (27).…”

Section: Discussionmentioning

confidence: 99%

In vitro activities of ceftriaxone and fusidic acid against 13 isolates of Coxiella burnetii, determined using the shell vial assay

Torres

Raoult

1993

Antimicrob Agents Chemother

View full text Add to dashboard Cite

The susceptibilities of 13 isolates of Coxiella burnetii to fusidic acid and ceftriaxone were determined by use of the recently described shell vial assay (D. Raoult, H. Torres, and M. Drancourt, Antimicrob. Agents Chemother, 35:2070-2077, 1991). At a concentration of 4 micrograms/ml, ceftriaxone was bacteriostatic for four isolates and slowed the multiplication of the other nine. Fusidic acid at a concentration of 2 micrograms/ml was bacteriostatic for six isolates and slowed the multiplication of three others. These results show that these compounds could be effective in the phagolysosome of C. burnetii-infected cells.

show abstract

The Role of Fluoroquinolones in Sexually Transmitted Diseases

Tartaglione,

Hooton

1993

Pharmacotherapy

View full text Add to dashboard Cite

The management of sexually transmitted diseases (STDs) has reached a new level in the era of antibiotic resistance and human immunodeficiency virus infection. To date, no single antimicrobial is capable of eradicating the commonly encountered STD pathogens including Neisseria gonorrhoeae, Chlamydia trachomatis, and Treponema pallidum. Among the marketed fluoroquinolones, ciprofloxacin, ofloxacin, lomefloxacin, and enoxacin all provide excellent in vitro activity (MIC90 < 0.06 μg/ml) and excellent in vivo efficacy against N. gonorrhoeae, including multiply resistant isolates (penicillinase‐producing N. gonorrhoeae and chromosomally mediated resistant N. gonorrhoeae). Ofloxacin is the only fluoroquinolone approved by the Food and Drug Administration for chlamydial infection. All of the quinolones lack reliable in vitro activity against Ureaplasma urealyticum, a cause of nongonococcal urethritis. Although limited data suggest the usefulness of ciprofloxacin and ofloxacin in the treatment of pelvic inflammatory disease, these drugs cannot currently be recommended for single‐agent therapy. Haemophilus ducreyi infections, however, can be managed effectively with the fluoroquinolones. Although their role continues to evolve, this class of drugs cannot be used equally to treat all STDs, and notably, no quinolone to date inhibits T. pallidum.

show abstract

In vitro activities of lomefloxacin, tetracycline, penicillin, spectinomycin, and ceftriaxone against Neisseria gonorrhoeae and Chlamydia trachomatis

Abstract: In vitro lomefloxacin was highly active against 208 penicillin-susceptible and -resistant isolates of Neisseria gonorrhoeae. However, its MIC and MBC against 10 isolates of Chlamydia trachomatis were 2 and greater than 4 micrograms/ml, respectively.

Cited by 10 publications

References 11 publications

In Vitro Effects of Spectinomycin and Ceftriaxone Alone or in Combination with Other Antibiotics against Chlamydia trachomatis

In Vitro Effects of Spectinomycin and Ceftriaxone Alone or in Combination with Other Antibiotics against Chlamydia trachomatis

In vitro activities of ceftriaxone and fusidic acid against 13 isolates of Coxiella burnetii, determined using the shell vial assay

The Role of Fluoroquinolones in Sexually Transmitted Diseases

Contact Info

Product

Resources

About