In vitro activities of antimicrobial agents against Candida species

Giuliana, G; Pizzo, Giuseppe; Milici, Maria Eleonora; Giangreco, Rosalia

doi:10.1016/s1079-2104(99)70293-3

Cited by 43 publications

(33 citation statements)

References 43 publications

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“…The former (C) has in its composition HEX (0.1%), while the latter (D) has only alcohol and excipients. The ability of CHX to inhibit C. albicans growth is well documented [1,12,[33][34][35]. It seems that CHX associated with alcohol is an effective combination in this species control.…”

Section: Discussionmentioning

confidence: 99%

Susceptibilities of Candida albicans Mouth Isolates to Antifungal Agents, Essentials Oils and Mouth Rinses

et al. 2012

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Forty Candida albicans strains isolated from patient's mouth with fixed orthodontic appliances were analyzed to their susceptibilities to antifungal agents, mouth rinses and essential oils. Susceptibility to fluconazole, econazole, miconazole and ketoconazole, amphotericin B and nystatin was assessed by the disk diffusion (DD) method based on the Clinical and Laboratory Standards Institute M44-A protocol, and by Etest (fluconazole and amphotericin B). The susceptibilities to mouth rinses and essential oils were also determined by the DD technique. All isolates tested were susceptible (S) to amphotericin B, nystatin and fluconazole. The overall concordance between the DD and the Etest was 100% for amphotericin and fluconazole. One isolate was resistant to econazole (2.5%) and the other to ketoconazole (2.5%). Econazole and ketoconazole had the highest percentages of susceptible dose dependent (SDD), 55 and 95%, respectively. Regarding to the susceptibility isolates profile, seven phenotypes were detected, and the 3 more represented (90% of the isolates) of them were SDD to one, two or three azoles. The study of mouth rinses showed a high variability of efficacy against C. albicans. The results showed that the isolates susceptibility to essential oils differed (P \ 0.05). The profile activity was: cinnamon [ laurel [ mint [ eucalyptus [ rosemary [ lemon [ myrrh [ tangerine. The main finding was that the susceptibility to cinnamon and laurel varied among the three more representative antifungal phenotypes (P \ 0.05). The susceptibility of econazole-SDD isolates to cinnamon and lemon was higher than those of the econazole-S yeasts (P \ 0.05). In contrast, econazole-SDD isolates were less affected by laurel than econazole-S counterparts (P \ 0.05).

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Section: Discussionmentioning

confidence: 99%

Susceptibilities of Candida albicans Mouth Isolates to Antifungal Agents, Essentials Oils and Mouth Rinses

et al. 2012

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“…16 Another antimicrobial incorporated in some mouthwashes, cetylpyridinium chloride, has been reported, in vitro, to have greater fungicidal activity than chlorhexidine. 17 The essential oil, tea tree oil, is available in proprietary products for the treatment of vaginal candidosis; an …”

Section: Discussionmentioning

confidence: 99%

Patterns of antifungal prescribing in general dental practice

et al. 2004

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Objective To examine the current practice of antifungal prescribing by GDPs in the United Kingdom. Design A postal questionnaire circulated to a random selection of 400 dentists. Outcome measures The questionnaires were analysed and the responses expressed as absolute and relative frequencies. Results Responses to the questionnaire were received from 297 (74.3%) GDPs. Nystatin was the most popular choice of antifungal agent that GDPs would use, followed by miconazole, amphotericin B and fluconazole. The likelihood of use of miconazole was positively linked to recent date of graduation. Lack of knowledge regarding contraindications and problems with azole antibiotics was found in a significant minority of practitioners (36%). Conclusions The present study indicates that azole antifungal agents (especially miconazole) are becoming more widely used by GDPs, but that knowledge regarding potential problems with their use is suboptimal. Nystatin remains the most popular choice of antifungal agent.Much attention has been focused on the prescribing of antibiotics recently. Such interest has largely examined antibacterial prescribing but there has been less work examining antifungal prescribing. Given that there is increasing evidence of Candida species becoming resistant to some antifungal agents, particularly the azole group, 1 it is timely to examine the current prescribing habits in general dental practice.Lewis et al. 2 investigated the prescribing of antibiotics by general dental practitioners (GDPs) in the United Kingdom in 1987. Since that study, newer azole antifungals, namely fluconazole, have become available in general dental practice. However, the azoles, unlike the polyene antifungals, are absorbed from the gastrointestinal tract and thus have the potential for interactions with other drugs. They also have the potential to be hepatotoxic. Over the last few years four antifungal drugs in a number of formulations, have been available for GDPs to prescribe under NHS regulations. 3 Nysatin is available as pastilles, suspension and ointment for extra-oral use on the skin, while amphotericin is only available in lozenges and suspension for intra-oral use. Miconazole is available as an oral gel as well as an ointment and cream (combined with 1% hydrocortisone) for use on the skin. Fluconazole capsules and suspension are available for oral/systemic use.The aim of the present study was to establish the types and formulations of antifungal agents prescribed by a cross section of general dental practitioners during 1999/2000. We wanted to examine if prescribing habits were influenced by the time since graduation and the possession of postgraduate qualifications. Also, we wished to examine the awareness of practitioners regarding contraindications to, and problems with azole antifungals. MATERIALS AND METHODSThe postal addresses of dental practitioners were obtained from the 1999 UK Dental Register. An initial total of 400 practitioners were selected by choosing every 74th entry in the register. Each of these dentists ...

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“…In the present study, all the temporary crowns were made with a methacrylate resin that demonstrated bacterial resistance (24)(25). The cementing was carried out very carefully in order to prevent the dislocation of residual cement in the peri-implant soft tissues.…”

Section: Fig 2 Sem Evaluation Ofthe Implant-abutm Ent Connection Inmentioning

confidence: 99%

Histological Evaluation of Peri-Implant Soft Tissues in Immediately Loaded Implants Featuring Different Implant-Abutment Connections: A Preliminary Study

Guerra¹,

Vozza

Quaranta

2012

Eur J Inflamm

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The aim of the present study is to evaluate the peri-implant soft tissues and the amount of inflammatory cells around two different implant-abutment connections (self-locking conical connection with platform switching and screwed connection with standard abutment and internal anti-rotational system). Histological analysis was made of 14 implants, 7 with self-locking Morse tapered connection (experimental group A) and 7 with screw-retained anti-rotational connection (control group B). Sixty days after non-functional immediate loading, peri-implant tissue biopsies were performed. In the samples taken from the experimental group the peri-implant connective tissue consisted of a greater density of collagen and fibroblasts compared to the connective tissue of the control group. The experimental group specimens showed less inflammatory infiltrate close to the self-locking tapered connection compared to the tissues around the screw-retained connection. The SEM observations showed less microgap in the self-locking conical connection than in the screw connections with standard abutment and internal anti-rotational system. The presence of connective tissue with few inflammatory cells and the absence of inflammatory infiltrate, in self-locking conical connection implants is due to the minimal size of the implant-abutment microgap that does not allow the passage of fluids and bacteria from the oral cavity to the implant thus preventing tissue inflammation.

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In vitro activities of antimicrobial agents against Candida species

Cited by 43 publications

References 43 publications

Susceptibilities of Candida albicans Mouth Isolates to Antifungal Agents, Essentials Oils and Mouth Rinses

Susceptibilities of Candida albicans Mouth Isolates to Antifungal Agents, Essentials Oils and Mouth Rinses

Patterns of antifungal prescribing in general dental practice

Histological Evaluation of Peri-Implant Soft Tissues in Immediately Loaded Implants Featuring Different Implant-Abutment Connections: A Preliminary Study

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