In vitro acaricidal activity of Cymbopogon citratus, Cymbopogon nardus and Mentha arvensis against Rhipicephalus microplus (Acari: Ixodidae)

Silva, Larissa Clara da; Perinotto, Wendell Marcelo de Souza; Sá, Fillipe A.; Souza, Marco Andre Alves de; Bitencourt, Ricardo de Oliveira Barbosa; Sanavria, Argemiro; Santos, Huarrisson Azevedo; Marie-Magdeleine, Carine; Angelo, Isabele da Costa

doi:10.1016/j.exppara.2020.107937

Cited by 17 publications

(8 citation statements)

References 56 publications

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“…Clove oil was effective in eliminating Ctenocephalides spp. fleas, similar to a study by [ 26 ]. However, no study of the effectiveness of the Z. limonella , citronella, peppermint, and ginger essential oils against Ctenocephalides spp.…”

Section: Discussionsupporting

confidence: 90%

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Essential oil pharmaceuticals for killing ectoparasites on dogs

Tadee,

Chansakaow,

Tipduangta

et al. 2024

J Vet Sci

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Background External parasites, particularly ticks and fleas, are among the most common problems affecting dogs. Chemical medicines are commonly used to prevent and eliminate such external parasites, but their improper use can cause adverse reactions, and the toxins they contain may remain in the environment. Objectives The objective of this study was to investigate the in vitro efficacy of Zanthoxylum limonella , citronella, clove, peppermint, and ginger essential oils against dog ticks and fleas and to test the sensitivity of dogs’ skin to these essential oils. Methods The five essential oils were tested for in vitro efficacy against ticks and fleas, and the two most effective essential oils were then tested on the dogs’ skin. Results The results revealed that these five essential oils at 16% concentrations effectively inhibited the spawning of female engorged ticks. In addition, all five essential oils had a strong ability to kill tick larvae at concentrations of 2% upward. Furthermore, 4% concentrations of the five essential oils quickly eliminated fleas, especially clove oil, which killed 100% of fleas within 1 h. A 50%, 90%, and 99% lethal concentration (LC 50 , LC 90 , and LC 99 ) for the essential oils on tick larvae in 24 h were found to be low values. LC 50 , LC 90 , and LC 99 for the essential oils on flea in 1 h was lowest values. Clove oil at 16% concentration was the most satisfactory essential oil for application on dogs’ skin, with a low percentage of adverse effects. Conclusions This study confirmed the effectiveness of essential oils for practical use as tick and flea repellents and eliminators. Essential-oil-based pharmaceutical can replace chemical pesticides and provide benefits for both consumers and the environment.

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Section: Discussionsupporting

confidence: 90%

“…The mortality rate of tick larvae was as high as 99.58% when exposed to 2% citronella oil, whereas [ 26 ] observed a mortality rate of 66%. Interestingly, all five essential oils tested in this study were highly effective in treating tick larvae when used at concentrations of 2% or higher.…”

Section: Discussionmentioning

confidence: 99%

Essential oil pharmaceuticals for killing ectoparasites on dogs

Tadee,

Chansakaow,

Tipduangta

et al. 2024

J Vet Sci

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“…Moreover, all treatments in the present study showed active high performance, such that they acted efficiently in the initial stages of the parasite cycle, both under laboratory conditions (in vitro) and under semi-natural conditions (ex situ). In addition, the life stage of ticks is an important factor that needs to be considered in order to achieve success in strategic control (Silva et al, 2020). In this light, it can be asserted that TrEOs constitute alternatives that in the future may help in combating cattle ticks with minimal environmental impact, thereby improving on the existing protocols for treatments at this stage of the cycle of this ectoparasite.…”

Section: Discussionmentioning

confidence: 99%

Activity of essential oils from leaves, flower buds and stems of Tetradenia riparia on Rhipicephalus (Boophilus) microplus larvae

Cella

Rahal

Silva

et al. 2023

Rev. Bras. Parasitol. Vet.

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Around the world, the main problems of livestock are caused by ectoparasites, however, commercial acaracide are toxic to the environment and detrimental to One Health. Therefore, research has increasingly focused on development of natural products as alternatives for tick control. The purpose of this study was to evaluate the larvicidal effect on Rhipicephalus (Boophilus) microplus, through use of essential oils (EOs) extracted from the leaves, flower buds and stems of Tetradenia riparia. The chemical composition of these EOs was determined through gas chromatography coupled to mass spectrometry (GC-MS). They were tested on larvae at concentrations of 100.000 to 40 µg/mL, using the larval packet test and under semi-natural conditions. The main class of compounds in the chemical composition was sesquiterpenes (both oxygenates and hydrocarbons), whereas the predominant compounds in the leaves, flower buds and stems were 14-hydroxy-9-epi-caryophyllene, T-cadinol and 6-7-dehydroroyleanone, respectively. The leaves proved to be the most effective, with highest larvicidal activity (LC99.9 = 83.53 µg/mL). When tested under semi-natural conditions, the oils obtained efficiency above 98% in all compound tests. The results indicated that these EOs were effective against R. (B.) microplus larvae in vitro and ex-situ, proving that this plant has bioactive molecules with significant larvicidal activity.

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“…The 10 essential oil Cymbopogon nardus (L.) Rendle that were evaluated for the study came from the literature [11].…”

Section: Methodsmentioning

confidence: 99%

In Silico Prediction of Essentials Oil From Cymbopogon Nardus as Immunomodulator in Rheumatoid Arthritis

et al. 2022

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Objective: Rheumatoid arthritis (RA) is an autoimmune disease involving the synovial lining of the major joints. Our study involves bioactive compounds of Cymbopogon Nardus as possible Rheumatoid arthritis drugs in silico targeted TNF-α, JAK1/2, JAK3, PAD4, and DHFR. Methods: Using computational docking and receptors from the Protein Data Bank (PDB) files 2AZ5, 3EYG, 3LXY, 1DLS, and 1WDA. Molegro Virtual Docker 6.0 was utilized to undertake an in silico anti-arthritis drugs study. ChemDraw 3D was utilized to minimize the ligand's energy before docking, and the structures Native Ligand were employed as positive control medications. A pharmacokinetic and toxicological study was performed using SwissADME (ADME) and PK-CMS. Results: Using the Moldock SE mechanism calculates the binding (atom) energies of each protein (Enzyme) and each ligand at the least energetic conformation state. Docking results of ten tested bioactive compounds have not displayed the Lowest rerank score scores and best fit within the prominent active site residues. Conclusion: The Essentials oils from Cymbopogon nardus have not effectively suppressed the Rheumatoid Arthritis pathway through inhibition of TNF-α, JAK1/2, JAK3, PAD4, and DHFR which can serve as potential lead compounds for the development of new drugs for the treatment of Rheumatoid Arthritis.

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In vitro acaricidal activity of Cymbopogon citratus, Cymbopogon nardus and Mentha arvensis against Rhipicephalus microplus (Acari: Ixodidae)

Cited by 17 publications

References 56 publications

Essential oil pharmaceuticals for killing ectoparasites on dogs

Essential oil pharmaceuticals for killing ectoparasites on dogs

Activity of essential oils from leaves, flower buds and stems of Tetradenia riparia on Rhipicephalus (Boophilus) microplus larvae

In Silico Prediction of Essentials Oil From Cymbopogon Nardus as Immunomodulator in Rheumatoid Arthritis

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