In utero sonographic description of a fetal liver adenoma.

Marks, Frances; Thomas, Peter T.; Lustig, Ilana; Greco, M. Alba; Raghavendra, B N; Wasserman, Richard C.

doi:10.7863/jum.1990.9.2.119

Cited by 7 publications

(4 citation statements)

References 2 publications

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“…Benign calcifications associated with either previous inflammation or infection, hepatic venous congestion and hepatomegaly associated with hydrops fetalis, and benign and malignant neoplasms have all been reported. [1][2][3] While the liver disease associated with hydrops fetalis is often a secondary manifestation of the disease, instances occur in which a primary abnormality of the liver may result in nonimmune hydrops. We describe a case of fetal cirrhosis secondary to hemochromatosis occurring as nonimmune hydrops fetalis.…”

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confidence: 99%

“…liver, neoplasms including adenomas and hamartomas, and metastatic disease have all been described sonographically. [1][2][3] Congenital (perinatal, neonatal) hemochromatosis is characterized clinically by severe neonatal liver failure and histologically by prominent stainable iron in the parenchymal cells of the liver and other viscera. 9 Oligohydramnios may be seen.…”

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confidence: 99%

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Prenatal sonographic findings in fetal cirrhosis secondary to hemochromatosis.

Skaife

Coakley

2000

Journal of Ultrasound in Medicine

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confidence: 99%

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confidence: 99%

Prenatal sonographic findings in fetal cirrhosis secondary to hemochromatosis.

Skaife

Coakley

2000

Journal of Ultrasound in Medicine

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“…Primary liver tumors are relatively uncommon and account for 6% to 8% of benign and malignant tumors in the first month of life [6]. Hepatic tumors in the perinatal period most commonly are hemangioma, infantile hemangioendothelioma, mesenchymal hamartoma and hepatoblastoma, and, more rarely, hepatic adenoma, teratoma, and FNH [6,7]. The ages of 10 telangiectatic FNH cases in the report of Paradis et al [8] ranged from 11 to 50 years.…”

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confidence: 99%

Telangiectatic Focal Nodular Hyperplasia of the Liver in the Perinatal Period: Case Report

Okamura

Nakadate²,

Ishida

et al. 2005

Pediatr Dev Pathol

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We report a case of congenital telangiectatic focal nodular hyperplasia, a rare variant form of the disease. The patient was a 2-month-old boy whose parents noticed abdominal distention about 2 weeks after birth, and ultrasonogram revealed a large mass in the liver. He underwent right lobectomy, and gross findings showed an ill-defined mass without any central scar. Histologic findings demonstrated proliferating hepatocytes without atypia arranged in cords of 1- or 2-cell thickness with marked sinusoidal dilatation and extramedullary hematopoiesis. In addition, a significantly increased Ki-67 labeling index in the tumor compared with non-tumor liver cells, and cytogenetic analysis of 23 G-banded metaphase preparations revealed 3 abnormal karyotypes, suggesting hyperplastic or neoplastic features. To the best of our knowledge, the present case is only the third documented case of congenital telangiectatic focal nodular hyperplasia.

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“…84 Right-side lateralisation of cardiac malformations has previously been reported after maternal ingestion of this drug during pregnancy. 134 The fourth case is a fetal liver adenoma 106 after a pregnancy during which the mother was given progesterone, corticosteroids and weekly hCG injections. This observation is very similar to a case of hepatic focal nodular hyperplasia in a 2year-old boy who was also exposed prenatally to oral prednisone and vaginal progesterone to avoid fetal loss.…”

Section: Other Observationsmentioning

confidence: 99%

Antenatal therapeutic drug exposure and fetal/neonatal tumours: review of 89 cases

Satgé

Sasco

Little

1998

Paediatric Perinatal Epid

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Although case reports on the association between neonatal tumours and maternal therapeutic drug use during pregnancy are cited regularly, no systematic review has been published. In a systematic search of the literature on fetal and neonatal tumours, we identified 36 malignant and 54 benign tumours in 89 fetuses and neonates prenatally exposed to various drugs. Six associations with in utero exposure are noteworthy: (1) phenytoin and neuroblastoma, as already suspected; (2) antibiotics and leukaemias; (3) hormonal treatment and vascular tumours; (4) acetaminophen (paracetamol) and fusocellular sarcoma; (5) acetaminophen in combination with petroleum products and hepatoblastoma; and (6) dicyclomine hydrochloride and teratomas. In view of the high level of consumption of drugs by pregnant women and the rarity of neonatal tumours, a possible carcinogenic effect is difficult to establish. However, some associations already observed in older infants, children and adults after antenatal and postnatal exposure to the same drugs are of note. We suggest that these drugs may act as carcinogens or as co-carcinogens in association with other physical and chemical agents and/or a particular genetic background. We therefore feel it is important to encourage the systematic collection, registration and publication of case reports on this subject. The hypotheses generated thereby could then be tested by formal epidemiological studies.

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In utero sonographic description of a fetal liver adenoma.

Cited by 7 publications

References 2 publications

Prenatal sonographic findings in fetal cirrhosis secondary to hemochromatosis.

Prenatal sonographic findings in fetal cirrhosis secondary to hemochromatosis.

Telangiectatic Focal Nodular Hyperplasia of the Liver in the Perinatal Period: Case Report

Antenatal therapeutic drug exposure and fetal/neonatal tumours: review of 89 cases

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