In utero PCB/PCDF exposure: Relation of developmental delay to dysmorphology and dose

Yu, Mei-Lin; Hsu, Chen‐Chin; Gladen, Beth C.; Rogan, Walter J.

doi:10.1016/0892-0362(91)90011-k

Cited by 64 publications

(24 citation statements)

References 17 publications

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“…For example, women who conceived after eating cooking oil contaminated with polychlorinated biphenyls (PCBs) gave birth to infants with yusho (3). The mechanism responsible is felt to be storage of PCBs in adipose tissue during exposure, which are then mobilized during pregnancy (4,5). Another example is that of a woman who was inadequately treated for plumbism in childhood and who gave birth to an infant with congenital lead poisoning (6).…”

Section: Exposurementioning

confidence: 99%

How are children different from adults?

Bearer

1995

Environ Health Perspect

238

101

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Several factors alter an individual's risk for an environmentally related illness. A major determinant is the age of the individual. The toxicodynamic processes that determine exposure, absorption, metabolism, excretion, and tissue vulnerability are all age related. This paper discusses each of these processes and their variability with age, and illustrates these points with examples of environmentally related disease cases. -Environ Health Perspect 1 03(Suppl 6): 7-12 (1995)

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Section: Exposurementioning

confidence: 99%

How are children different from adults?

Bearer

1995

Environ Health Perspect

238

101

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“…A previous examination of the MFE Cohort included an initial assessment of a small pilot study sample assembled in 1973, the full cohort available in 1979-1982, and finally in 1989-1991(He et al 2001. Linking these three time intervals, after stratification by fisheater versus non-fisheater status, consumption of sport-caught fish, male sex, and increasing age were predictors of serum levels of Aroclor 1260.…”

Section: Article | Changes In Serum Pcb Levelsmentioning

confidence: 99%

“…Polychlorinated biphenyls (PCBs) have been linked to a broad range of adverse health effects in humans, from developing fetuses to aging adults (Fein et al 1984;Hicks 1996;Lai et al 2001;Persky et al 2001;Rylander et al 1998;Sauer et al 1994;Schantz et al 1996;Yu et al 1991). However, efforts to ascertain historical PCB exposure and determine a causal relationship with health outcomes such as cancer and immune dysfunction have yielded inconsistent results (Hansen 1998;Kimbrough 1995;Wolff and Toniolo 1995).…”

mentioning

confidence: 99%

A longitudinal examination of factors related to changes in serum polychlorinated biphenyl levels.

Tee

Sweeney

Symanski

et al. 2003

Environ Health Perspect

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Consumption of sport-caught fish from the Great Lakes is a recognized source of human exposure to polychlorinated biphenyls (PCBs). Understanding temporal changes in PCB body burden is crucial for evaluating exposure levels and augmenting validity of studies investigating their relationship to adverse health effects. Using data collected from 1980 to 1995, we evaluated longitudinal changes in serum PCB levels among 179 fisheaters and non-fisheaters of the Michigan Fisheater Cohort. Participants identified as fisheaters in 1980 ate 26 lb or more of sport-caught fish per year, whereas non-fisheaters ate less than 6 lb per year. We found a monotonic decline in serum PCB levels among all participants from a mean value of 24 ppb in 1980 to 12 ppb in 1994. This was paralleled by an 83% decrease in mean fish consumption among all participants over the same period. We combined demographic, lifestyle, and fish consumption information with PCB data and evaluated the data using regression models to identify predictors of PCB body burden over a 16-year period. Results of the mixed-effects linear regression model suggest that consumption of Lake Michigan fish before 1980, amount of sport-caught fish eaten in the past year, age, and year of data collection were significant determinants of current PCB body burden over the 16-year study period. PCB levels were particularly elevated for males who were classified as fisheaters in 1980, which may reflect higher levels of sport-caught fish consumption compared with female fisheaters.

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“…A 1991 study on the lasting effects of exposure to olive oil contaminated in 1979 by polychlorinated biphe nyls, reported significant developmental delays in children exposed in utero to the chemicals in the m others' diets. In addition, some of these children were born with clinical evidence of intoxication [18]. Diethylstilbestrol is a model of transplacental carcinogenesis in humans [19], while there are multiple animal models of this phenomenon [20,21].…”

Section: Discussionmentioning

confidence: 99%

Autoantibodies and Clinical Rheumatic Complaints in Two Children of Women with Silicone Gel Breast Implants

Teuber

Gershwin

1994

Int Arch Allergy Immunol

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Considerable interest and efforts are directed at determining the extent to which silicone gel breast implants may contribute to the risk of developing autoimmune disease. There is also comparable interest in determining the extent to which silicone may alter the natural history of an established autoimmune disease. Recently, there has been concern over the possibility that children of women with silicone breast implants might somehow be adversely affected because of either trans-mammary or trans-placental delivery of silicone during either breast feeding or pregnancy. Herein, we describe two children of mothers with silicone breast implants, both female, aged approximately 3 and 9 years, both of whom had long-standing myalgias that were unexplained and did not fit current clinical criteria for juvenile arthritis. Both were found to have positive antinuclear antibodies. Additionally, the 9-year-old girl was found to have a significantly high titer of antibodies against denatured human type II collagen; indeed, her titer was six standard deviations above the mean for normal controls. There have been numerous previous studies which have documented an adverse impact of trace metals, chemicals and some medications on the morphologic and neurologic development of children exposed in utero. Much less information exists on potential toxicity experienced by a neonate through breast feeding, although examples of toxic transmission have been reported. In Western Europe, but not the United States, women with silicone breast implants are advised not to breast feed. Further research should address these concerns and, in particular, women with silicone breast implants, with evidence of leakage or rupture, should refrain from breast feeding until further data are obtained.

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In utero PCB/PCDF exposure: Relation of developmental delay to dysmorphology and dose

Cited by 64 publications

References 17 publications

How are children different from adults?

How are children different from adults?

A longitudinal examination of factors related to changes in serum polychlorinated biphenyl levels.

Autoantibodies and Clinical Rheumatic Complaints in Two Children of Women with Silicone Gel Breast Implants

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