In utero nicotine exposure promotes M2 activation in neonatal mouse alveolar macrophages

Wongtrakool, Cherry; Grooms, Kora; Ping, Xiao-Du; Rivera, Hilda N.; Ward, Judson C.; Roser‐Page, Susanne; Roman, Jesse; Brown, Lou Ann S.; Gauthier, Theresa W.

doi:10.1038/pr.2012.55

Cited by 26 publications

(16 citation statements)

References 35 publications

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“…Indeed, it has been shown that exposure to pre‐natal smoking lead to low sperm counts (Ravnborg et al ., ). The production of cytokines by the resident testicular MO after nicotine exposure has not been addressed yet, but a possible negative alteration in MO function cannot be excluded, as it has been shown that in utero nicotine exposure affects alveolar MO function (Wongtrakool et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue

et al. 2014

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SUMMARYNicotine is largely consumed as a component of cigarettes. It induces apoptosis, interferes with endocrine function by changing the sex hormones secretion and leads to male infertility. Testosterone is produced from cholesterol by Leydig cells (LC), with the participation of testicular macrophages (MO). Thus, to investigate whether nicotine administration to pregnant and lactating rats changes cholesterol and sexual hormone levels and LC and MO populations of offspring, female rats received nicotine (2 mg/kg/day) through osmotic minipumps from the first day of pregnancy up to the end of weaning. At 1, 30, 60 and 90 days post-partum (dpp) the plasma cholesterol and testosterone levels were obtained, as well as the biometric, histopathological and stereological testicular parameters. Nicotine reduced the body weight, cholesterol levels and lipid droplet number in foetal LC at 1 dpp. The number of apoptotic LC did not change in the offspring of nicotine group at any age studied. No alterations in the numerical densities of MO and LC occurred at 60 and 90 dpp. Hypertrophy of mature LC and increase in cholesterol and testosterone levels were noted at 90 dpp. In conclusion, nicotine when administered to rats throughout pregnancy and lactation induces morphofunctional alterations of foetal and mature LC and affects cholesterol and testosterone levels.

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Section: Discussionmentioning

confidence: 97%

Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue

et al. 2014

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“…Nicotine has been shown to impair antibacterial defenses 178,179 and alter macrophage activation. [180][181][182] In a set of experiments using a mouse model, ECIG aerosol exposure resulted in airway inflammation, impaired immunological response to bacteria and viruses, and impaired bacterial phagocytosis. 183 Exposure to ECIG aerosol (1.8% nicotine; 2-s, 35-mL puff taken every 10 s diluted into air at 1.05 L/min) also increased virus-caused morbidity and mortality.…”

Section: Immunologic Systemmentioning

confidence: 99%

Electronic cigarettes: what are they and what do they do?

Breland

Soule

Lopez

et al. 2016

Annals of the New York Academy of Sciences

280

269

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Electronic cigarettes (ECIGs) use electricity to power a heating element that aerosolizes a liquid that often contains solvents, flavorants, and the dependence-producing drug nicotine for user inhalation. ECIGs have evolved rapidly in the past 8 years, and the changes in product design and liquid constituents affect the resulting toxicant yield in the aerosol and delivery to the user. This rapid evolution has been accompanied by dramatic increases in ECIG use prevalence in many countries, including among adults and especially adolescents in the United States. This increased prevalence of a novel product that has the potential to deliver nicotine and other toxicants to users’ lungs drives a rapidly growing research effort. This review highlights the most recent information regarding the design of ECIGs and liquid and aerosol constituents, the epidemiology of ECIG use among adolescents and adults (including correlates of ECIG use), and preclinical and clinical research regarding ECIG effects. The current literature suggests a strong rationale for an empirical regulatory approach toward ECIGs that balances any potential ECIG-mediated decreases in health risks for smokers who use them as substitutes for tobacco cigarettes and against any increased risks for nonsmokers who may be attracted to them.

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“…With prenatal nicotine exposure expression of α 7 -nAChR is enhanced in the neonatal lung [154]. Further, the risk of infant respiratory tract infections is supposed to be enhanced by in utero nicotine exposure, due to α 7 -nAChR-mediated influence on alveolar macrophages [155]. …”

Section: Reproductive Systemmentioning

confidence: 99%

The Non-Neuronal Cholinergic System in Health and Disease

Beckmann¹,

Lips²

2013

Pharmacology

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Acetylcholine (ACh) is not only a neurotransmitter but is an ancient molecule that can be released by and act on non-neuronal cells. In these cells the system of ACh-synthesizing enzymes, transporters, receptors and degrading enzymes is termed the non-neuronal cholinergic system (NNCS). There is increasing evidence that the NNCS is dysregulated in various diseases and can have an influence on their pathology. However, for many organ systems not much is known about the expression and function of the NNCS. Thus, this review focusses on the role of the NNCS in different organ systems in health and disease. Dysregulation of ACh synthesis and release, mutations or polymorphisms in genes encoding NNCS components, and auto-antibodies against NNCS components are common factors influencing disease progression. Pharmacological agents targeting the NNCS are already successfully in clinical use for some disorders, indicating that interfering with this system is very promising and more research is needed to elucidate the role of the NNCS in different tissues and pathological states.

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In utero nicotine exposure promotes M2 activation in neonatal mouse alveolar macrophages

Cited by 26 publications

References 35 publications

Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue

Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue

Electronic cigarettes: what are they and what do they do?

The Non-Neuronal Cholinergic System in Health and Disease

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