In utero metabolomic signatures of refined grain intake and risk of gestational diabetes: A metabolome-wide association study

Chehab, Rana F.; Ferrara, Assiamira; Zheng, Scott; Barupal, Dinesh Kumar; Ngo, Amanda; Chen, Liwei; Fiehn, Oliver; Zhu, Yeyi

doi:10.1016/j.ajcnut.2023.02.009

Cited by 4 publications

(4 citation statements)

References 49 publications

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“…Several observational studies have shown that the consumption of refined grains and dairy products was significantly associated with gestational diabetes and adverse birth outcomes. [32][33][34] It has been suggested that alterations in specific circulating metabolites induced by the intake of refined grains and dairy products may contribute to this effect. [32,35] These metabolites could potentially modulate mTOR kinase activity and disrupt intracellular signaling pathways, thereby contributing to insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

“…[32][33][34] It has been suggested that alterations in specific circulating metabolites induced by the intake of refined grains and dairy products may contribute to this effect. [32,35] These metabolites could potentially modulate mTOR kinase activity and disrupt intracellular signaling pathways, thereby contributing to insulin resistance. [32] However, the exact mechanism of the associations between the specific protein intakes and plasma amino acids warrants further exploration.…”

Section: Discussionmentioning

confidence: 99%

“…[32,35] These metabolites could potentially modulate mTOR kinase activity and disrupt intracellular signaling pathways, thereby contributing to insulin resistance. [32] However, the exact mechanism of the associations between the specific protein intakes and plasma amino acids warrants further exploration.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Dietary Protein Intake from Different Sources on Maternal and Umbilical Cord Plasma Amino Acid Levels

Zhao,

Wang,

Liu

et al. 2024

Molecular Nutrition Food Res

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ScopeTo assess the associations of dietary protein intake from different sources during pregnancy with maternal and umbilical cord plasma amino acid levels.Methods and resultsThe study includes 216 pregnant women and 39 newborns from the Tongji Birth Cohort in Wuhan, China. The study examines the levels of 21 amino acids in maternal and cord plasma samples using ultra‐performance liquid chromatography with tandem mass spectrometry. A significant positive relationship is observed between dietary protein intake from refined grains and maternal plasma cysteine levels. Dietary protein intake from dairy products is positively associated with maternal plasma levels of sulfur amino acid (mainly cystine), but negatively associated with maternal plasma levels of glutamic acid. In addition, the study observes that pre‐pregnancy body mass index and parity may be potential determinants of maternal plasma amino acid levels, whereas a history of passive smoking during pregnancy is an important factor influencing cord plasma amino acid levels.ConclusionsThese findings suggest that dietary protein intakes from specific sources during pregnancy may affect maternal plasma levels of amino acids.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of Dietary Protein Intake from Different Sources on Maternal and Umbilical Cord Plasma Amino Acid Levels

Zhao,

Wang,

Liu

et al. 2024

Molecular Nutrition Food Res

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“…Finally, a total of 163 subjects including 67 DOR patients and 96 controls were enrolled in the discovery set ( Figure 1 A). To derive the validation set, we randomly selected 22 pair participants in the TREE cohort who were not included in the discovery set [ 43 ]. The detailed participant selection flowchart is shown in Figure S1 .…”

Section: Methodsmentioning

confidence: 99%

Metabolomic Analysis Reveals Association between Decreased Ovarian Reserve and In Vitro Fertilization Outcomes

An,

Zhang,

Zhu

et al. 2024

Metabolites

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In vitro fertilization (IVF) is a highly effective treatment for infertility; however, it poses challenges for women with decreased ovarian reserve (DOR). Despite the importance of understanding the impact of DOR on IVF outcomes, limited research has explored this relationship, particularly using omics approaches. Hence, we conducted a study to investigate the association between DOR and IVF outcomes, employing a metabolomic approach. We analyzed serum samples from 207 women undergoing IVF treatment, including 89 with DOR and 118 with normal ovarian reserve (NOR). Our findings revealed that DOR was significantly associated with unfavorable IVF outcomes, characterized by a reduced oocyte count, lower embryo quality, and decreased rates of pregnancy and live births. Furthermore, we identified 82 metabolites that displayed significant alterations in DOR patients, impacting diverse metabolic pathways. Notably, a distinct panel of metabolites, including palmitic acid, stearic acid, LysoPC(9:0(CHO)/0:0), PC(18:0/9:0(CHO)), and PC(16:0/9:0(CHO)), exhibited discriminatory power between the DOR and NOR groups, showcasing a strong correlation with IVF outcomes. These findings emphasize the crucial role of metabolomic disruptions in influencing IVF outcomes among women with DOR.

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Effect of ultra‐fine ground whole grain highland barley substitution on wheat dough properties and bread qualities

Liu,

Xu,

Zhang

et al. 2024

Cereal Chem

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Background and ObjectiveThere is a growing interest in incorporating whole grain highland barley (HB) to wheat bread for improving nutrients and potential health benefits. However, the qualities and sensory properties of whole grain‐based bread were reduced compared to refined wheat‐based bread due to the strong water absorption and large particle size of dietary fiber in whole grain. Therefore, ultra‐fine ground whole grain HB partially substituted 5%–40% wheat flour to make bread, and the relevant dough properties and bread qualities were studied.FindingsThe increased addition of ultra‐fine ground whole grain HB from 5% to 40% to wheat increased dough development time, whereas, decreased dough stability time, elasticity, pH, G′ modulus, and G″ modulus. The increased substitution of ultra‐fine ground whole grain HB to wheat further reduced the specific volume, cohesiveness, elasticity, and resilience of bread, whereas, increased the hardness, adhesiveness, and chewiness of bread.ConclusionsThe partial substitution of wheat with ultra‐fine ground whole grain HB from 5% to 40% wheat significantly affected wheat‐HB dough properties and resultant bread qualities mainly due to weakened gluten networking.Significance and NoveltyThe 5%–10% substitution of wheat by ultra‐fine ground whole grain HB showed the optimum dough properties and bread qualities compared to other treatments, which substituted 20%–40% wheat flour.

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In utero metabolomic signatures of refined grain intake and risk of gestational diabetes: A metabolome-wide association study

Cited by 4 publications

References 49 publications

Effect of Dietary Protein Intake from Different Sources on Maternal and Umbilical Cord Plasma Amino Acid Levels

Effect of Dietary Protein Intake from Different Sources on Maternal and Umbilical Cord Plasma Amino Acid Levels

Metabolomic Analysis Reveals Association between Decreased Ovarian Reserve and In Vitro Fertilization Outcomes

Effect of ultra‐fine ground whole grain highland barley substitution on wheat dough properties and bread qualities

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