In Utero/Lactational 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure Impairs Molar Tooth Development in Rats

Kattainen, Hanna; Tuukkanen, Juha; Simanainen, Ulla; Tuomisto, Jouni T.; Kovero, Outi; Lukinmaa, Pirjo‐Liisa; Alaluusua, Satu; Viluksela, Matti

doi:10.1006/taap.2001.9216

Cited by 57 publications

(40 citation statements)

References 27 publications

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“…Certain dioxins are reported to cause developmental dental defects in rodents (Alaluusua et al, 1993;Kattainen et al, 2001;Kiukkonen et al, 2002;Lukinmaa et al, 2001;Sahlberg et al, 2002) and children (Alaluusua et al, 1996(Alaluusua et al, , 1999Holtta et al, 2001). Such defects in children are of concern be-cause they occur at low-dose levels and are usually permanent (Kattainen et al, 2001). This study describes developmental maxillary incisor defects in female Sprague-Dawley rats treated for 13 weeks with HCB.…”

Section: Introductionmentioning

confidence: 99%

Hexachlorobenzene-Induced Incisor Degeneration in Sprague—Dawley Rats

2004

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Hexachlorobenzene (HCB) was administered to female Sprague-Dawley rats in a 13-week toxicity study conducted for the National Toxicology Program (NTP). Groups of 10 rats were treated by gavage with 0.0, 0.03, 0.1, 0.3, 1.0, 3.0, 10, or 25 mg/kg HCB in corn oil 5 days/week for 13 weeks. Dose-dependent, region-specific, maxillary incisor degeneration was observed in animals given HCB at doses of 1.0 mg/kg/day and higher. Treatment with 1.0 mg/kg/day resulted in focal mesenchymal cell vacuolation and focal osteodentin formation within the pulp. Lesions were restricted to a short linear region subjacent to the odontoblast layer along the lateral aspect of the incisor at the level of the dentin-enamel interface. When observed in both incisors, lesions were bilaterally symmetric. Treatment with 3.0 mg/kg/day resulted in lateral and medial pulp lesions and focal odontoblast degeneration with dentin niche formation along the lateral incisor margin in some animals. Treatment with 10 mg/kg/day resulted in a higher incidence of lateral dentin niches and a low incidence of medial dentin niches. In animals treated with 25 mg/kg/day, a high incidence of bilaterally symmetric, lateral and medial, dentin niches were observed. The morphology and distribution of HCB-induced incisor lesions in rats are consistent with injury to a selective population of preodontoblasts.

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Section: Introductionmentioning

confidence: 99%

Hexachlorobenzene-Induced Incisor Degeneration in Sprague—Dawley Rats

2004

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“…This result differs from those of other studies, which show that lactating pups frequently lacked third molars when administered a single dose of 50 or 1000 mg/kg TCDD at PND1 or when pregnant dams were exposed to 1 mg/kg TCDD on gestation day 15. 22,7 We suggest two reasons to explain the difference between these studies and ours as follows: First, TCDD administered at 5 mg/kg may be insufficient to arrest the development of the third molar. Second, TCDD was administered too late to induce molar agenesis.…”

Section: Discussionmentioning

confidence: 54%

Exposure to a continuous low dose of tetrachlorodibenzo-p-dioxin impairs the development of the tooth root in lactational rats and alters the function of apical papilla-derived stem cells

Guo¹,

Zhang²,

Wei³

et al. 2015

Archives of Oral Biology

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“…The detrimental effect of TCDD on tooth development has been well demonstrated (Alaluusua et al, 1993;Kattainen et al, 2001), so it is surprising that we failed to detect changes in molar size and shape with TCDD exposure. Perhaps the date of dosing used in this study was less suitable for causing detectable changes in overall molar size and shape than it was for mandible traits (Allen and Leamy, 2001;Miettinen et al, 2002).…”

Section: Discussionmentioning

confidence: 75%

2,3,7,8-Tetrachlorodibenzo-p-dioxin affects fluctuating asymmetry of molar shape in mice, and an epistatic interaction of two genes for molar size

et al. 2007

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Fluctuating asymmetry (FA), random variation between left and right sides in a bilaterally symmetrical character, is a commonly used measure of developmental instability that is expected to increase with increasing environmental stress. One potential stressor is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a powerful toxicant known to disturb tooth development. In this study, mice in the F 2 generation produced from an intercross between two inbred strains (C57BL/6J and AKR/J) were exposed in utero to TCDD. We hypothesized that TCDD would increase FA in the molars of exposed mice over that of the control mice. In addition, we hypothesized that we would discover genes for molar size, shape or asymmetry whose expression would be affected by TCDD. We detected a very small, but significant, increase in FA of molar shape (but not size) in the TCDD-exposed mice compared to the control mice, although molar size and shape did not differ between these groups. Although we did not uncover any genes that acted differently in the TCDD exposed and control groups, we did identify two genes whose dominance by additive epistatic effect on molar size was affected by TCDD. We concluded that although TCDD may be affecting the expression of some genes governing the development of molars in our population of mice, FA of molar size and shape is not a particularly sensitive indicator of this effect.

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In Utero/Lactational 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure Impairs Molar Tooth Development in Rats

Cited by 57 publications

References 27 publications

Hexachlorobenzene-Induced Incisor Degeneration in Sprague—Dawley Rats

Hexachlorobenzene-Induced Incisor Degeneration in Sprague—Dawley Rats

Exposure to a continuous low dose of tetrachlorodibenzo-p-dioxin impairs the development of the tooth root in lactational rats and alters the function of apical papilla-derived stem cells

2,3,7,8-Tetrachlorodibenzo-p-dioxin affects fluctuating asymmetry of molar shape in mice, and an epistatic interaction of two genes for molar size

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