In utero Exposure to Oxcarbazepine Causes Congenital Anomalies in Albino Rat Fetuses

Hamdi, Hamida; Ghareeb, Ahmed; Kandil, Asmaa M.; Ahmed, Osama M.; Yahia, Rania

doi:10.9734/jamps/2017/32345

Cited by 3 publications

(2 citation statements)

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“…The mean crown lump length was also found to be statistically significantly low in the high dose group when phenobarbital was dispensed during the first trimester (TM1) and second trimester (TM2), compared to that of Table 3.1. This current study's results are in agreement with those of a study done by Hamdi et al (2016) which depicted that in the valproic acidtreated group, an anticonvulsant in the same generation as phenobarbital, there was a significant reduction in crown lump length and foetal weight in comparison to the control group. Another study also done by El-Gaafarawi and Abouel-Magd (2015) showed that upon administration of anticonvulsants like carbamazepine, which is in the same generation as phenobarbital, there was decreased crown-rump length and foetal body weight among groups exposed to carbamazepine compared to control.…”

Section: Discussionsupporting

confidence: 92%

The intra-uterine effects of phenobarbital on fetal growth and development in albino rats (Rattus Norvegicus)

Segut,

Kweri,

Mwangi

et al. 2024

jagst

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The intrauterine developmental consequences of phenobarbital, when administered in varied doses, on foetal growth and development remain poorly understood. This study is therefore set to evaluate the intrauterine effects of phenobarbital at differing doses when administered at different incubation periods in albino rats. In carrying out this study, a post-test only control experimental study design was adopted, and a sample size of 30 Albino rats was used. These rats were obtained from the Small Animal Facility for Research and Innovation in the School of Biomedical Sciences at Jomo Kenyatta University of Agriculture and Technology. They were arbitrarily allocated into two large study groups of 3 control rats and 27 experimental rats. The 27 rats in the experimental group were further subdivided into three study groups of 9 rats, each with low, medium, and high phenobarbital doses. On gestation day 20, all the rats were humanely sacrificed, and three fetuses from each rat were selected. The parameters evaluated in this study included the foetal weight, bi-parietal diameters, and crown lump length. The data was collected using a structured checklist, then entered into the computer using an Excel spreadsheet. The data was then exported to the Statistical Package for the Social Scientist (SPSS). To determine the causal effects, the statistical significance was determined by using Tukey’s post hoc multiple comparison tests, and all values with a p value less than 0.05 were considered to be significant. This research discovered that there was a reduction in all foetal parameters, which was statistically significant (P<0.05), especially during trimesters one and two. The effects of phenobarbital administered on foetal parameters depended on the time of exposure and dose administered. Phenobarbital, administered prenatally, had dose- and time-dependent effects on foetal parameters. Therefore, more studies need to be done on higher primates to ascertain their teratogenic safety in pregnancy.

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Section: Discussionsupporting

confidence: 92%

The intra-uterine effects of phenobarbital on fetal growth and development in albino rats (Rattus Norvegicus)

Segut,

Kweri,

Mwangi

et al. 2024

jagst

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“…The current study results are intendem with results of a previous study by (Hamdi et al, 2017) that showed that oxcarbazepine (OXC), a new anticonvulsant medicine like lamotrigine that is recently being prescribed widely as first line adjunct medicine as well as monotherapy, has a potential risk of causing a reduction in fetal weight. Another previous study results by Harden (2014) reported that upon administration of topiramate and zonisamide, second-generation anticonvulsant medicines in the same category as lamotrigine, there was associated fetal weight loss.…”

Section: Discussionmentioning

confidence: 70%

The growth and development outcomes of foetuses born of albino rats (Rattus Norvegicus) prenatally exposed to varying doses of lamotrigine

Mwangi,

Kweri,

Kweri

et al. 2023

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The growth and development outcomes of the foetuses born by mothers who prenatally get exposed to lamotrigine (LAMT) have not been well established. Lamotrigine is an anticonvulsant medicine used in the management of acute epileptic seizures, Lennox-Gastaut syndrome, fibromyalgia, schizophrenia, unipolar depression, bipolar I disorder maintenance among others. Though currently lamotrigine is being prescribed as a first line medicine in the management of these maternal conditions, past studies are not conclusive on its teratogenic effects on growth and development of embryos and foetuses upon its in-utero exposure, with some demonstrating no effects, while others recommend further studies. Data on growth and development effects upon administration of lamotrigine at varying dosages at different trimesters will therefore be of help to the expectant mothers who consume lamotrigine, developing embryos and foetuses as well as guide the clinicians on the dosage and when to prescribe lamotrigine. A post- test-only experimental design was adopted using 30 female sexually mature rats of 250 + 30grams.These female albino rats were divided into two main groups of 3 rats in the control group and 27 rats in the dosage group. Excel spreadsheets were used to code the data and was analyzed in SPSS. Study findings were expressed as mean + standard error of the mean (SEM). Values whose p<.05 were reported as being statistically significant different. Study findings depicted a reduction in mean fetal weight (FW), mean crown-rump length (CRL), mean bi-parietal diameter (BD), mean head circumference (HC) as well as mean head length (HL) in a time and dose related manner. More reduction in foetal growth and development parameters were observed in high lamotrigine dosages, especially when administrations were done during the first and the second trimesters. Further studies with animals close to human species are recommended to guide on the safety human therapeutic dosages.

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In utero Exposure to Oxcarbazepine Causes Congenital Anomalies in Albino Rat Fetuses

Cited by 3 publications

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The intra-uterine effects of phenobarbital on fetal growth and development in albino rats (Rattus Norvegicus)

The intra-uterine effects of phenobarbital on fetal growth and development in albino rats (Rattus Norvegicus)

The growth and development outcomes of foetuses born of albino rats (Rattus Norvegicus) prenatally exposed to varying doses of lamotrigine

Teratogenic potential of third-generation antiepileptic drugs: Current status and research needs

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