In utero exposure to environmental lead and manganese and neurodevelopment at 2 years of age

Lin, Ching Chun; Chen, Yu Chuan; Su, Feng; Lin, Chien-Mu; Liao, Hua; Hwang, Yaw-Huei; Hsieh, Wu‐Shiun; Jeng, Suh‐Fang; Su, Yi Ning; Chen, Pau‐Chung

doi:10.1016/j.envres.2013.03.003

Cited by 140 publications

(128 citation statements)

References 33 publications

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“…Another relevant finding of this study is also related to the observed interaction between Mn and Pb on neurobehavioral outcomes that has already been shown measures of fetal exposure in pregnancy (Lin et al, 2013), early childhood (Claus Henn et al, 2012) and school aged children (Kim et al, 2009). As Pb is ubiquitous and there is no known exposure level without deleterious health effects, potential interactions with Pb exposure should always be verified in human studies on Mn neurotoxicity.…”

Section: Discussionmentioning

confidence: 54%

Neurofunctional dopaminergic impairment in elderly after lifetime exposure to manganese

et al. 2014

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Background Manganese (Mn) is an essential element that can become neurotoxic through various exposure windows over the lifespan. While there is clear evidence of Mn neurotoxicity in pediatric and adult occupational populations, little is known about effects in the elderly who may exhibit enhanced susceptibilities due to compromised physiology compared to younger adults. In the province of Brescia, Italy, the Valcamonica area has been the site of three ferroalloy plants operating from 1902 to 2001. Metal emissions of Mn and to a lesser extent lead (Pb) have impacted the surrounding environment, where a high prevalence of Parkinsonism was previously observed. This study aimed to assess neurocognitive and motor functions in healthy elderly subjects residing for most of their lifetime in Valcamonica or in a reference area unimpacted by ferroalloy plant activity. Methods Subjects were enrolled for extensive neurobehavioral assessment of motor, cognitive and sensory functions. Exposure was assessed with 24hour personal air sampling for PM10 airborne particles, surface soil and tap water measurement at individual households, Mn levels in blood and urine and Pb in blood. Dose-response relationships between exposure indicators and biomarkers and health outcomes were analyzed with Generalized (linear and logistic) Additive Models (GAM). Results A total of 255 subjects (55% women) were examined; most (52.9%) were within the 65–70 years age class. Average airborne Mn was 26.41 ng/m3 (median 18.42) in Valcamonica and 20.96 ng/m3 (median 17.62) in the reference area. Average Mn in surface soil was 1026 ppm (median 923) in Valcamonica and 421 ppm (median 410) in the reference area. Manganese in drinking water was below the LDL of 1 µg/L. The GAM analysis showed significant association between airborne Mn (p=0.0237) and the motor coordination tests of the Luria Nebraska Neuropsychological Battery. The calculation of the Benchmark Dose using this dose response relationship yielded a lower level confidence interval of 22.7 ng/m3 (median 26.4). For the odor identification score of the Sniffin Stick test, an association was observed with soil Mn (p=0.0006) and with a significant interaction with blood Pb (p=0.0856). Significant dose-responses resulted also for the Raven’s Colored Progressive Matrices with the distance from exposure point source (p=0.0025) and Mn in soil (p=0.09), and for the Trail Making test, with urinary Mn (p=0.0074). Serum prolactin (PRL) levels were associated with air (p=0.061) and urinary (p=0.003) Mn, and with blood Pb (p=0.0303). In most of these associations age played a significant role as an effect modifier. Conclusion Lifelong exposure to Mn was significantly associated with changes in odor discrimination, motor coordination, cognitive abilities and serum PRL levels. These effects are consistent with the hypothesis of a specific mechanism of toxicity of Mn on the dopaminergic system. Lead co-exposure, even at very low levels, can further enhance Mn toxicity.

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Section: Discussionmentioning

confidence: 54%

Neurofunctional dopaminergic impairment in elderly after lifetime exposure to manganese

et al. 2014

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“…All four of the prospective studies reviewed support the notion that the prenatal and early postnatal period may be a sensitive developmental window for Mn exposure with regards to neurodevelopment [58, 61, 67, 68]. In a large prospective cohort study of neonates from China, a cord serum Mn threshold of 5 μg/L was identified, above which three-day-olds showed cognitive deficits as measured by the Neonatal Behavioral Neurological Assessment (NBNA) [67].…”

Section: Epidemiologic Evidence For Neurotoxic Effects Of Manganesementioning

confidence: 99%

Perinatal and Childhood Exposure to Cadmium, Manganese, and Metal Mixtures and Effects on Cognition and Behavior: A Review of Recent Literature

Sanders

Henn

Wright

2015

Curr Envir Health Rpt

249

134

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Lead (Pb) and mercury (Hg) neurotoxicity is well established. In recent years, a growing body of evidence suggests that environmental exposure to other metals including arsenic (As), cadmium (Cd), manganese (Mn), and their mixtures also pose public health threats. In this paper we summarize the recent literature examining the relationship of prenatal and childhood environmental metal exposures with cognitive and behavioral outcomes in children. We conducted a literature search to identify epidemiologic studies that examined the relationship of Cd, Mn, and metal mixtures with children’s neurodevelopmental/cognitive and behavioral outcomes. We restricted the search to peer-reviewed studies published in English between January 2009 and March 2015. We identified a total of 31 articles of which 16, 17, and 16 studies examined the effects of Cd, Mn, or metal mixtures, respectively. Based on our review, there is suggestive evidence that prenatal/childhood Cd exposure may be associated with poorer cognition, but additional research is clearly needed. We found little evidence of behavioral effects of early life Cd exposure, and no studies found a significant relationship with attention deficit hyperactivity disorder. Studies of early life Mn exposure consistently reported negative impacts on both cognition and behavior. There is also growing evidence that co-exposure to multiple metals can result in increased neurotoxicity compared to single metal exposures, in particular during early life. Few studies have evaluated behavioral effects related to metal co-exposures.

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“…In children, higher Mn levels in blood and hair have been associated with poorer mental development (Claus Henn et al 2010), lower full-scale and verbal intelligence quotient (Menezes-Filho et al 2011), lower verbal and performance intelligence quotient (Riojas-Rodriguez et al 2010), poorer attention and non-verbal memory (Takser et al 2003), increased externalizing behavior problems (Ericson et al 2007), and more oppositional and hyperactive behaviors (Bouchard et al 2011). An interaction between Mn and lead resulting in poorer overall, cognitive and language development has also been observed (Lin et al 2013). Water contaminated with Mn is one potential exposure pathway (Bouchard et al 2011; Wasserman et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Determinants of manganese levels in house dust samples from the CHAMACOS cohort

Gunier

Jerrett

Smith

et al. 2014

Science of The Total Environment

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Introduction Manganese (Mn) is an essential nutrient, but at high exposure levels Mn is a neurotoxicant. The fungicides maneb and mancozeb are approximately 21% Mn by weight and more than 150,000 kg are applied each year to crops in the Salinas Valley, California. It is not clear, however, whether agricultural use of these fungicides increases Mn levels in homes. Materials and methods We collected house dust samples from 378 residences enrolled in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study with a second sample collected approximately nine months later from 90 of the residences. House dust samples were analyzed for Mn using inductively coupled plasma optical emission spectroscopy. Information from interviews, home inspections, and pesticide use reports was used to identify potential predictors of Mn dust concentrations and loadings. Results Mn was detectable in all dust samples. The median Mn concentration was 171 μg/g and median Mn loading was 1,910 μg/m2 at first visit. In multivariable models, Mn dust concentrations and loadings increased with the number of farmworkers in the home and the amount of agricultural Mn fungicides applied within three kilometers of the residence during the month prior to dust sample collection. Dust concentrations of Mn and other metals (lead, cadmium and chromium) were higher in residences located in the southern Salinas Valley compared those located in other areas of the Salinas Valley. Dust loadings of Mn and other metals were also higher in residences located on Antioch Loam soil than other soil types, and in homes with poor or average housekeeping practices. Conclusions Agricultural use of Mn containing fungicides was associated with Mn dust concentrations and loadings in nearby residences and farmworker homes. Housekeeping practices and soil type at residence were also important factors related to dust metal concentrations and loadings.

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In utero exposure to environmental lead and manganese and neurodevelopment at 2 years of age

Cited by 140 publications

References 33 publications

Neurofunctional dopaminergic impairment in elderly after lifetime exposure to manganese

Neurofunctional dopaminergic impairment in elderly after lifetime exposure to manganese

Perinatal and Childhood Exposure to Cadmium, Manganese, and Metal Mixtures and Effects on Cognition and Behavior: A Review of Recent Literature

Determinants of manganese levels in house dust samples from the CHAMACOS cohort

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