In utero exposure to bisphenol-A and its effect on birth weight of offspring

Miao, Maohua; Yuan, Wei; Zhu, Guoping; He, Xiao Shun; Li, De-Kun

doi:10.1016/j.reprotox.2011.03.002

Cited by 105 publications

(67 citation statements)

References 27 publications

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“…However, these authors found no associations with female babies (see Supplemental Material, Table S4). These results are consistent with a retrospective cohort study that included 587 births in which maternal and paternal occupational exposure to BPA were both associated with low birth weight and small gestational size; the association was stronger for maternal exposure than paternal exposure (Miao et al 2011b). Further, in a Dutch population-based prospective cohort study of 219 pregnant women, urinary BPA was positively associated with lower growth rates and smaller head circumference (Snijder et al 2013).…”

Section: Birth Weightsupporting

confidence: 89%

Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013

Peretz

Vrooman

Ricke

et al. 2014

Environ Health Perspect

453

301

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Background: In 2007, an expert panel reviewed associations between bisphenol A (BPA) exposure and reproductive health outcomes. Since then, new studies have been conducted on the impact of BPA on reproduction.Objective: In this review, we summarize data obtained since 2007, focusing on a) findings from human and animal studies, b) the effects of BPA on a variety of reproductive end points, and c) mechanisms of BPA action.Methods: We reviewed the literature published from 2007 to 2013 using a PubMed search based on keywords related to BPA and male and female reproduction.Discussion: Because BPA has been reported to affect the onset of meiosis in both animal and in vitro models, interfere with germ cell nest breakdown in animal models, accelerate follicle transition in several animal species, alter steroidogenesis in multiple animal models and women, and reduce oocyte quality in animal models and women undergoing in vitro fertilization (IVF), we consider it an ovarian toxicant. In addition, strong evidence suggests that BPA is a uterine toxicant because it impaired uterine endometrial proliferation, decreased uterine receptivity, and increased implantation failure in animal models. BPA exposure may be associated with adverse birth outcomes, hyperandrogenism, sexual dysfunction, and impaired implantation in humans, but additional studies are required to confirm these associations. Studies also suggest that BPA may be a testicular toxicant in animal models, but the data in humans are equivocal. Finally, insufficient evidence exists regarding effects of BPA on the oviduct, the placenta, and pubertal development.Conclusion: Based on reports that BPA impacts female reproduction and has the potential to affect male reproductive systems in humans and animals, we conclude that BPA is a reproductive toxicant.Citation: Peretz J, Vrooman L, Ricke WA, Hunt PA, Ehrlich S, Hauser R, Padmanabhan V, Taylor HS, Swan SH, VandeVoort CA, Flaws JA. 2014. Bisphenol A and reproductive health: update of experimental and human evidence, 2007–2013. Environ Health Perspect 122:775–786; http://dx.doi.org/10.1289/ehp.1307728

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Section: Birth Weightsupporting

confidence: 89%

Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013

Peretz

Vrooman

Ricke

et al. 2014

Environ Health Perspect

453

301

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“…As reported by Miao et al (2011) [90] birth weight was significantly lower in the children of mothers exposed to BPA than those of the not exposed mothers. The same is true for the children whose fathers were exposed, compared to the children of not exposed fathers.…”

Section: Children's Development Birth Weightsupporting

confidence: 59%

“…It was observed that exposure to BPA in the workplace was associated with a decreased birth weight of neonates. The progeny of fathers exposed to BPA had birth weight which was by 90.75 g lower than the average weight -3308.60±539.91 g (p = 0.10), and the progeny of mothers exposed during pregnancy had birth weight lower by 168.40 g (M±SD: 3299.40±428 g) (p = 0.02), compared to the not exposed group, in which the average birth weight of the newborns was 3398.74±523.61 g [90]. Chou et al (2011) [91], observed a similar relationship.…”

Section: Children's Development Birth Weightmentioning

confidence: 89%

Bisphenol A – Application, sources of exposure and potential risks in infants, children and pregnant women

Mikołajewska¹,

Stragierowicz²,

Gromadzińska³

2015

Int J Occup Med Environ Health

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Bisphenol A (BPA) is used in the chemical industry as a monomer in the production of plastics. It belongs to a group of compounds that disturb some of the functions of human body, the endocrine system in particular. Extensive use of BPA in manufacturing products that come in contact with food increases the risk of exposure to this compound, mainly through the digestive tract. Literature data indicate that exposure to bisphenol A even at low doses may result in adverse health effects. The greatest exposure to BPA is estimated among infants, children and pregnant women. The aim of this review is to show potential sources of exposure to bisphenol A and the adverse health effects caused by exposure to this compound in the group of particular risk.

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“…Prenatal exposure to BPA has been shown to be negatively associated with BMI, adiposity, and percent body fat in young girls (403) (143) as well as associated with decreased birth weight (269). On the other hand, early exposure to BPA in ages 4–15 has been associated with increased BMI, obesity, and waist circumference (403) (143) (405) (417) (394); however, one study did show a negative association between BPA levels and BMI in 6–9 year old girls (428).…”

Section: Associations Between Pop Exposures and The Development Of Obmentioning

confidence: 99%

Adipose Tissue as a Site of Toxin Accumulation

Jackson

Shoemaker

Larian

et al. 2017

Comprehensive Physiology

126

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We examine the role of adipose tissue, typically considered an energy storage site, as a potential site of toxicant accumulation. Although the production of most persistent organic pollutants (POPs) was banned years ago, these toxicants persist in the environment due to their resistance to biodegradation and widespread distribution in various environmental forms (e.g., vapor, sediment, water). As a result, human exposure to these toxicants is inevitable. Largely due to their lipophilicity, POPs bioaccumulate in adipose tissue, resulting in greater body burdens of these environmental toxicants with obesity. POPs of major concern include polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and furans (PCDDs/PCDFs), and polybrominated biphenyls and diphenyl ethers (PBBs/PBDEs), among other organic compounds. In this review, we 1) highlight the physical characteristics of toxicants that enable them to partition into and remain stored in adipose tissue, 2) discuss the specific mechanisms of action by which these toxicants act to influence adipocyte function, and 3) review associations between POP exposures and the development of obesity and diabetes. An area of controversy relates to the relative potential beneficial versus hazardous health effects of toxicant sequestration in adipose tissue.

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In utero exposure to bisphenol-A and its effect on birth weight of offspring

Cited by 105 publications

References 27 publications

Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013

Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013

Bisphenol A – Application, sources of exposure and potential risks in infants, children and pregnant women

Adipose Tissue as a Site of Toxin Accumulation

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