In-utero carbon monoxide poisoning and multiple fetal abnormalities

Hennequin, Yves; Blum, Denise; Vámos, Eszter; Steppe, M; Goedseels, J.; Cavatorta, E

doi:10.1016/0140-6736(93)90102-m

Cited by 10 publications

(2 citation statements)

References 3 publications

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“…The legs demonstrated absent left femur with right femoral hypoplasia, bilateral tibial hemimelia (absent tibia) and laterally missing toes (Ingalls & Philbrook, 1958). Another infant who was exposed to chronic CO from around 10 weeks to the 7th month of gestation was born with multiple congenital anomalies, including complex congenital heart defects, cleft lip and palate, bilateral retinal colobomas, hypoplastic external genitalia, and low set ears (Hennequin et al, 1993). While karyotype was normal, no further evaluations for a known single gene disorder were available at the time and the authors felt that the clinical features were consistent with CHARGE association.…”

Section: Normal Carboxyhemoglobin Levels In Nonsmoking Pregnantmentioning

confidence: 99%

Hypoxia: A teratogen underlying a range of congenital disruptions, dysplasias, and malformations

Adam¹,

Payton

Sanchez‐Lara

et al. 2021

American J of Med Genetics Pt A

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In this review, we explore evidence that hypoxia in the developing human fetus can lead not only to the more commonly accepted disruptive-type defects, but also patterns of anomalies that suggest that hypoxia can exert a more classic teratogenic effect, using the brain as one example. We review neuropathology in the context of intrauterine hypoxia, particularly as it relates to carbon monoxide poisoning, in utero strokes, and homozygous alpha-thalassemia. In general, the associated brain injuries resemble those seen with other causes of hypoxic-ischemic injury. Fetal strokes during development usually lead to loss of brain tissue in areas that do not follow a typical embryologic pattern, and therefore are considered disruptions. However, there is also evidence that fetal brain ischemia can cause more classically recognized patterns of abnormal embryonic neuronal migration and organization such as polymicrogyria, cortical dysplasia, or dysgenesis, including select types of focal cortical dysplasia. This study summarizes available literature and evidence to raise clinicians' awareness regarding the association between hypoxia and congenital anomalies, including brain malformations.

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Section: Normal Carboxyhemoglobin Levels In Nonsmoking Pregnantmentioning

confidence: 99%

Hypoxia: A teratogen underlying a range of congenital disruptions, dysplasias, and malformations

Adam¹,

Payton

Sanchez‐Lara

et al. 2021

American J of Med Genetics Pt A

View full text Add to dashboard Cite

show abstract

“…The fetus is inherently close to an anoxic state, as its oxygen partial pressure is between a fifth and a third that of the mother [ 11 ]. Studies have shown anatomical malformation of the fetus following acute intoxication of the mother [15], although not all intoxications lead to such effects. The mother is also somewhat compromised during CO exposure because of lower haemoglobin levels, an increased ventilation rate and an inherently higher endogenous HbCO level.…”

Section: Toxic Mechanisms and Health Effectsmentioning

confidence: 99%

Carbon Monoxide Exposure in the Home Environment and the Evaluation of Risks to Health - A UK Perspective

Green

Short

Shuker

et al. 1999

Indoor and Built Environment

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The causes and effects of exposure to high levels of carbon monoxide (CO) are well documented, and many countries maintain records of annual deaths arising from CO poisoning incidents. Many such incidents are associated with the use of badly installed, poorly maintained or malfunctioning domestic combustion appliances or with the use of such appliances in poorly ventilated rooms. However, the prolonged sequelae of acute CO poisoning and the chronic effects of long-term exposure to lower levels of CO are not well understood. The home environment is particularly important because of the possibility of unrecognised long-term, low-level exposure to CO. Furthermore, the common problem of missed or misdiagnosis of CO poisoning can result in exposed individuals being given inappropriate treatment and being returned to a hazardous situation.

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Smoking Cessation and Risk of Stroke in Women

Göcze¹

1993

JAMA

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In-utero carbon monoxide poisoning and multiple fetal abnormalities

Cited by 10 publications

References 3 publications

Hypoxia: A teratogen underlying a range of congenital disruptions, dysplasias, and malformations

Hypoxia: A teratogen underlying a range of congenital disruptions, dysplasias, and malformations

Carbon Monoxide Exposure in the Home Environment and the Evaluation of Risks to Health - A UK Perspective

Smoking Cessation and Risk of Stroke in Women

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