In utero and lactational exposure to methylmercury elicits physical-chemical and morphological damages in the alveolar bone of offspring rats: The first toxicological findings

Chemelo, Victória Santos; Nascimento, Priscila Cunha; Bittencourt, Leonardo Oliveira; Souza-Monteiro, Deiweson; Balbinot, Gabriela de Souza; Albuquerque, Alan Rodrigo Leal; Silva, Márcia Cristina Freitas; Paz, Simone Patrícia Aranha da; Angélica, Rômulo Simões; Prado, Alejandro Ferraz do; Martins, Manoela Domingues; Collares, Fabrício Mezzomo; Crespo-López, María Elena; Lima, Rafael Rodrigues

doi:10.1016/j.chemosphere.2022.136453

Cited by 4 publications

(3 citation statements)

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“…Amazonian populations subside on fish, the main protein of the diet ( 50 ), and, therefore, their exposure to MeHg is a chronic problem. Recently, we have demonstrated that indirect exposure of the mother to MeHg causes damage to several brain regions, salivary glands and alveolar bone in the offspring ( 15 , 21 , 51 ).…”

Section: Discussionmentioning

confidence: 99%

“…In calcified long tissues, a study demonstrated that prenatal exposure to MeHg led to a significant delay in the development of different components of the appendicular skeleton of rat fetuses, such as delays in the formation of ossification centers and decreased growth of long bones, altering bone mineral density and content ( 58 ). As in oral calcified tissues, maternal exposure to MeHg in alveolar bone was able to induce changes in mineral composition, cause histological damage to osteocytes and collagen associated with a decrease in the quantity and thickness of alveolar bone ( 21 ). Tooth enamel has also been shown to be a target of this exposure during its formation, as the highly regulated process called amelogenesis occurs during the developmental stages ( 59 ).…”

Section: Discussionmentioning

confidence: 99%

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Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels: a concern for oral health

Chemelo

Bittencourt

Nascimento

et al. 2023

Front. Public Health

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Although there are many studies on the health effects of methylmercury (MeHg) toxicity during in utero and early development, little is known about its effects on mineralized tissues present in the oral cavity, such as enamel structure. Therefore, this study evaluated the effects of MeHg exposure on the physico-chemical, ultrastructural and functional properties of mature tooth enamel. Specifically, we studied offspring of mothers exposed to MeHg during the prenatal and postnatal periods which are the developmental stages associated with tooth enamel formation. Female rats were exposed to MeHg at a dose of 40 μg/kg/day for 42 days of pregnancy and lactation. The enamel of offspring was analyzed by (1) Fourier Transform Infrared Spectroscopy and Raman to assess physicochemical composition, (2) Scanning Electron Microscopy for ultrastructural evaluation, (3) Transmitted Polarizing Light Microscopy for analysis of the enamel extracellular matrix, and (4) resistance and hardness were evaluated by microhardness. The results showed that MeHg exposure during this sensitive enamel formation period induced changes in inorganic and organic content and enamel prisms ultrastructure alterations and disturbed the organic extracellular matrix due to a decreased enamel strength. These novel findings establish for the first time that maternal exposure to MeHg pre and postnatal promoted relevant changes in mature enamel of their offspring rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels: a concern for oral health

Chemelo

Bittencourt

Nascimento

et al. 2023

Front. Public Health

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“…The histological assessments were performed according to Chemelo et al [ 22 ]. From each section, three photomicrographs were obtained from different fields of all animals.…”

Section: Methodsmentioning

confidence: 99%

Açai (Euterpe oleracea Mart.) supplementation promotes histological and ultrastructural changes in rats' alveolar bone

Moura,

Rodrigues,

Dos Santos

et al. 2024

Heliyon

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Transgenerational inheritance of methylmercury and vitamin A-induced toxicological effects in a Wistar rats environmental-based model

Carazza-Kessler,

Campos,

Bittencourt

et al. 2024

Chemosphere

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In utero and lactational exposure to methylmercury elicits physical-chemical and morphological damages in the alveolar bone of offspring rats: The first toxicological findings

Cited by 4 publications

References 50 publications

Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels: a concern for oral health

Maternal methylmercury exposure during early-life periods adversely affects mature enamel structure of offspring rats at human exposure levels: a concern for oral health

Açai (Euterpe oleracea Mart.) supplementation promotes histological and ultrastructural changes in rats' alveolar bone

Transgenerational inheritance of methylmercury and vitamin A-induced toxicological effects in a Wistar rats environmental-based model

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