In This Issue/Abstract Thinking: Of Mice, Monkeys, and Men

Singh, Manpreet K.

doi:10.1016/j.jaac.2011.12.013

Cited by 1 publication

(1 citation statement)

References 4 publications

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“…N. Pavuluri, et al, 2009). However, HBO did not exhibit elevated amygdalar activation to emotional faces in general, which is in contrast to previous findings of amygdalar hyperactivity during passive view of emotional faces in unaffected youth at risk of BD relative to healthy youth (Olsavsky, et al, 2012). The discrepancy of the amygdalar findings could be attributed to differences in the level of attentional resources required to perform the EFNBACK task.…”

Section: 0 Discussioncontrasting

confidence: 99%

Fronto-limbic function in unaffected offspring at familial risk for bipolar disorder during an emotional working memory paradigm

Ladouceur

Diwadkar

White

et al. 2013

Developmental Cognitive Neuroscience

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Evidence from neuroimaging studies indicate that individuals with bipolar disorder (BD) exhibit altered functioning of fronto-limbic systems implicated in voluntary emotion regulation. Few studies, however, have examined the extent to which unaffected youth at familial risk for BD exhibit such alterations. Using an fMRI emotional working memory paradigm, we investigated the functioning of fronto-limbic systems in fifteen healthy bipolar offspring (8–17 years old) with at least one parent diagnosed with BD (HBO), and 16 age-matched healthy control (HC) participants. Neural activity and functional connectivity analyses focused on a priori neural regions supporting emotion processing (amygdala, ventral striatum) and voluntary emotion regulation (ventrolateral prefrontal cortex (VLPFC), dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC)). Relative to HC, HBO exhibited greater right VLPFC (BA47) activation in response to positive emotional distracters and reduced VLPFC modulation of the amygdala to both the positive and negative emotional distracters; there were no group differences in connectivity for the neutral distracters. These findings suggest that alterations in the functioning of fronto-limbic systems implicated in voluntary emotion regulation are present in unaffected bipolar offspring. Future longitudinal studies are needed to determine the extent to which such alterations represent neurodevelopmental markers of risk for future onset of BD.

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Section: 0 Discussioncontrasting

confidence: 99%