2010
DOI: 10.1002/glia.20995
|View full text |Cite
|
Sign up to set email alerts
|

In the hypoxic central nervous system, endothelial cell proliferation is followed by astrocyte activation, proliferation, and increased expression of the α6β4 integrin and dystroglycan

Abstract: Cerebral hypoxia induces a profound angiogenic response in the central nervous system (CNS). Using a mouse model of chronic cerebral hypoxia, we previously demonstrated that angiogenic vessels in the hypoxic CNS show marked upregulation of the extracellular matrix (ECM) protein fibronectin, along with increased expression of its major receptor, α5β1integrin on brain endothelial cells (BEC). As cerebral hypoxia also leads to glial activation, the aim of the current study was to define the temporal relationship … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

18
70
0

Year Published

2011
2011
2018
2018

Publication Types

Select...
10

Relationship

1
9

Authors

Journals

citations
Cited by 64 publications
(89 citation statements)
references
References 39 publications
18
70
0
Order By: Relevance
“…This revealed that in both areas of the brain, compared with normoxic conditions, the percentage of low-CD105 vessels was significantly increased after 4 and 7 days hypoxia, but after 14 days hypoxia had started to decline back toward the normoxic level ( Figure 1C). This temporal profile closely resembles the angiogenic response previously characterized in the chronic hypoxia model (Li et al, 2010), consistent with the idea that remodeling BECs transiently downregulate CD105 expression.…”
Section: Cerebral Hypoxia Promotes the Appearance Of Vessels That Shosupporting
confidence: 87%
“…This revealed that in both areas of the brain, compared with normoxic conditions, the percentage of low-CD105 vessels was significantly increased after 4 and 7 days hypoxia, but after 14 days hypoxia had started to decline back toward the normoxic level ( Figure 1C). This temporal profile closely resembles the angiogenic response previously characterized in the chronic hypoxia model (Li et al, 2010), consistent with the idea that remodeling BECs transiently downregulate CD105 expression.…”
Section: Cerebral Hypoxia Promotes the Appearance Of Vessels That Shosupporting
confidence: 87%
“…4A), compatible with published data for CLDN5, OCLN and other CNS endothelial tight junction markers such as zona occludens 1 (now known as TJP1) (Argaw et al, , 2012Li et al, 2010). Numbers and organization of cortical NeuN + neurons were normal, with no apoptosis detected (Fig.…”
Section: Ddr and Vegfa Act In Combination To Induce Blood-brain Barrisupporting
confidence: 75%
“…In a chronic hypoxia model of cerebrovascular disease, angiogenesis proceeds in the absence of BBB leakage, being associated with increased tight junction protein expression [254]; this demonstrates that angiogenesis is not indissolubly linked to BBB breakdown. In addition, resolution of impeded angiogenesis in neural stem cell niches in the SVZ would increase oxygen levels and could also promote differentiation of oligodendrocyte precursors.…”
Section: Discussionmentioning
confidence: 90%