In the case of extensively putrefied bodies, the analysis of entomological samples may support and complement the toxicological results obtained with other alternative matrices

Aly, Sanaa M.; Gish, Alexandr; Hakim, Florian; Guelmi, Douniazad; Mesli, Vadim; Hédouin, V.; Allorge, Delphine; Gaulier, Jean-Michel

doi:10.1016/j.legalmed.2023.102261

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…This result agreed with the study of Vignali et al, where a weak positive correlation of postmortem interval was noted only for liver tissue [ 45 ]. When the post-mortem interval has been so long that extensively putrefied bodies are assessed, the analysis of entomological samples may support and complement the toxicological results [ 46 ]. Even in the case of dried blood spots, the quantification of quetiapine is possible with good recovery rates, within the concentration range of 0.05–1.0 μg/mL [ 47 ].…”

Section: Use and Misusementioning

confidence: 99%

Quetiapine-Related Deaths: In Search of a Surrogate Endpoint

Šoša

2024

Toxics

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Quetiapine is a second-generation antipsychotic drug available for two and half decades. Due to increased misuse, prescription outside the approved indications, and availability on the black market, it is being encountered in medicolegal autopsies more frequently. For instance, it has been linked to increased mortality rates, most likely due to its adverse effects on the cardiovascular system. Its pharmacokinetic features and significant postmortem redistribution challenge traditional sampling in forensic toxicology. Therefore, a systematic literature review was performed, inclusive of PubMed, the Web of Science—core collection, and the Scopus databases; articles were screened for the terms “quetiapine”, “death”, and “autopsy” to reevaluate each matrix used as a surrogate endpoint in the forensic toxicology of quetiapine-related deaths. Ultimately, this review considers the results of five studies that were well presented (more than two matrices, data available for all analyses, for instance). The highest quetiapine concentrations were usually measured in the liver tissue. As interpreted by their authors, the results of the considered studies showed a strong correlation between some matrices, but, unfortunately, the studies presented models with poor goodness of fit. The distribution of quetiapine in distinct body compartments/tissues showed no statistically significant relationship with the length of the postmortem interval. Furthermore, this study did not confirm the anecdotal correlation of peripheral blood concentrations with skeletal muscle concentrations. Otherwise, there was no consistency regarding selecting an endpoint for analysis.

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Section: Use and Misusementioning

confidence: 99%

Quetiapine-Related Deaths: In Search of a Surrogate Endpoint

Šoša

2024

Toxics

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“…Recently, a number of reports have investigated other possible samples, including cerumen (earwax) [53][54][55][56]; bone [99,100]; adipocere, also known as corpse wax, grave wax or mortuary wax; brain tissue; flies; and pupae [58]. Meier et al reported the detection time window of cerumen, commonly referred as earwax, to be reportedly in excess of that of urine but shorter than that reported for hair [55].…”

Section: Cerumenmentioning

confidence: 99%

New Applications of Gas Chromatography and Gas Chromatography-Mass Spectrometry for Novel Sample Matrices in the Forensic Sciences: A Literature Review

Gould,

Nguyen,

Honeychurch

2023

Chemosensors

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The investigation of novel sample matrices in the forensic sciences offers several possible advantages, such as allowing for results to be obtained in cases where common sample types are absent. This review focuses on the application of gas chromatography and gas chromatography–mass spectrometry (GC-MS) for the determination of drugs in alternative sample matrices, including hair, sweat, meconium, breast milk, and vitreous humour. Less common sample types are also reported including air, cerumen, insects, and their larvae and pupae. The application of pyrolysis GC-MS (Py GC-MS) is also reviewed, showing the possibility of determining high molecular weight drugs which would commonly be unattainable by GC-MS. The application of Py GC-MS for the simulation and investigation of the underlying chemistry and the products formed in the smoking of drugs is also reported.

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