In tandem effects of activated carbon and quorum quenching on fouling control and simultaneous removal of pharmaceutical compounds in membrane bioreactors

“…Second, considering the sophistication of micro-organism communities and the diversity of QS signals, we can hardly rely on a single quencher to effectively mitigate biofilm formation and accumulation (Ni and Wang, 2019); for example, the QQ consortium developed by Xiao et al (2018) provided a selective pressure on the biocake not only by preventing Gram-negative bacteria but also enriching Gram-positive bacteria, due to its capability to degrade AHLs but not AIPs. The sophisticated mechanisms of QS still need to be uncovered, and the combined effect of multiple quenchers deserves further investigation.…”

Section: Limitations Of Qq Strategies In Antifouling Applicationsmentioning

confidence: 99%

Innovative microbial disease biocontrol strategies mediated by quorum quenching and their multifaceted applications: A review

et al. 2023

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With the increasing resistance exhibited by undesirable bacteria to traditional antibiotics, the need to discover alternative (or, at least, supplementary) treatments to combat chemically resistant bacteria is becoming urgent. Quorum sensing (QS) refers to a novel bacterial communication system for monitoring cell density and regulation of a network of gene expression that is mediated by a group of signaling molecules called autoinducers (AIs). QS-regulated multicellular behaviors include biofilm formation, horizontal gene transfer, and antibiotic synthesis, which are demonstrating increasing pathogenicity to plants and aquacultural animals as well as contamination of wastewater treatment devices. To inhibit QS-regulated microbial behaviors, the strategy of quorum quenching (QQ) has been developed. Different quorum quenchers interfere with QS through different mechanisms, such as competitively inhibiting AI perception (e.g., by QS inhibitors) and AI degradation (e.g., by QQ enzymes). In this review, we first introduce different signaling molecules, including diffusible signal factor (DSF) and acyl homoserine lactones (AHLs) for Gram-negative bacteria, AIPs for Gram-positive bacteria, and AI-2 for interspecies communication, thus demonstrating the mode of action of the QS system. We next exemplify the QQ mechanisms of various quorum quenchers, such as chemical QS inhibitors, and the physical/enzymatic degradation of QS signals. We devote special attention to AHL-degrading enzymes, which are categorized in detail according to their diverse catalytic mechanisms and enzymatic properties. In the final part, the applications and advantages of quorum quenchers (especially QQ enzymes and bacteria) are summarized in the context of agricultural/aquacultural pathogen biocontrol, membrane bioreactors for wastewater treatment, and the attenuation of human pathogenic bacteria. Taken together, we present the state-of-the-art in research considering QS and QQ, providing theoretical evidence and support for wider application of this promising environmentally friendly biocontrol strategy.

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“…In most cases, adding QQ strains was used to control biofouling in MBRs, which was first reported in 2009 (Yeon et al, 2009). In addition, the stable operation of bioreactors after adding QQ strains indicated that the control of excessive biomass accumulation or biofouling by this QS inhibition method does not need a performance recovery period compared to other physical or chemical methods (Jiang et al, 2013b;Lee et al, 2018a;Xiao et al, 2018;Liu et al, 2021a;Wang et al, 2021a).…”

Section: Cultivating Qq Bacteriamentioning

confidence: 99%

Quorum sensing regulation methods and their effects on biofilm in biological waste treatment systems: A review

Sun

Yang

et al. 2021

Front. Environ. Sci. Eng.

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Quorum sensing (QS) plays an important role in microbial aggregation control. Recently, the optimization of biological waste treatment systems by QS regulation gained an increasing attention. The effects of QS regulation on treatment performances and biofilm were frequently investigated. To understand the state of art of QS regulation, this review summarizes the methods of QS enhancement and QS inhibition in biological waste treatment systems. Typical QS enhancement methods include adding exogenous QS molecules, adding QS accelerants and cultivating QS bacteria, while typical QS inhibition methods include additions of quorum quenching (QQ) bacteria, QS-degrading enzymes, QS-degrading oxidants, and QS inhibitors. The specific improvements after applying these QS regulation methods in different treatment systems are concluded. In addition, the effects of QS regulation methods on biofilm in biological waste treatment systems are reviewed in terms of biofilm formation, extracellular polymeric substances production, microbial viability, and microbial community. In the end, the knowledge gaps in current researches are analyzed, and the requirements for future study are suggested.

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In tandem effects of activated carbon and quorum quenching on fouling control and simultaneous removal of pharmaceutical compounds in membrane bioreactors

Cited by 37 publications

References 44 publications

Mitigation of membrane biofouling in membrane bioreactor treating sewage by novel quorum quenching strain of Acinetobacter originating from a full-scale membrane bioreactor

Mitigation of membrane biofouling in membrane bioreactor treating sewage by novel quorum quenching strain of Acinetobacter originating from a full-scale membrane bioreactor

Innovative microbial disease biocontrol strategies mediated by quorum quenching and their multifaceted applications: A review

Quorum sensing regulation methods and their effects on biofilm in biological waste treatment systems: A review

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