In systemic sclerosis macrovascular damage of hands digital arteries correlates with microvascular damage

Rosato, Edoardo; Gigante, Antonietta; Barbano, Biagio; Cianci, Rosario; Molinaro, Ilenia; Pisarri, Simonetta; Salsano, Felice

doi:10.1016/j.mvr.2011.07.009

Cited by 55 publications

(33 citation statements)

References 28 publications

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“…Rosato et al (9) had previously reported a correlation between macrovascular features in the hands of SSc patients evaluated by PDUS and microvessel involvement assessed by laser Doppler perfusion imaging or digital photoplethysmography (9,10). The proliferative obliterative vasculopathy characterizing Cutolo's late NFC pattern is especially associated with UAO in our study, supporting the hypothesis that micro-and macrovascular damages could be linked in SSc.…”

Section: Discussionsupporting

confidence: 87%

“…B-mode analysis and power Doppler evaluation are thus widely available. Only a few studies have explored the association between macrovascular damages evaluated by PDUS and microvascular involvement assessed by NFC (9,10). More specifically, these articles have supported the understanding that US evaluation may help to better characterize macrovascular involvement.…”

Section: Introductionmentioning

confidence: 99%

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Combination of Capillaroscopic and Ultrasonographic Evaluations in Systemic Sclerosis: Results of a Cross‐Sectional Study

Lescoat

Coiffier

Carlan

et al. 2018

Arthritis Care & Research

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Combination of Capillaroscopic and Ultrasonographic Evaluations in Systemic Sclerosis: Results of a Cross‐Sectional Study

Lescoat

Coiffier

Carlan

et al. 2018

Arthritis Care & Research

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“…It uses a low-intensity monochromatic laser beam to scan across a tissue surface and determine flux of blood cells moving through the dermal microvasculature [14,15]. For this reason, LDPI revealed to be a precious evidence-based adjunct to clinical evaluation of burn depth [16], as well as alterations due to systemic sclerosis [17], scleroderma, and primary Raynaud's phenomenon [18].…”

Section: Introductionmentioning

confidence: 99%

Nickel-Related Intestinal Mucositis in IBS-Like Patients: Laser Doppler Perfusion Imaging and Oral Mucosa Patch Test in Use

Borghini

Puzzono

Rosato

et al. 2016

Biol Trace Elem Res

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Nickel (Ni) is often the trigger of irritable bowel syndrome (IBS)-like gastrointestinal disorders: its ingestion may cause allergic contact mucositis, identifiable by means of oral mucosa patch test (omPT). OmPT effectiveness has been proven, but it is still an operator-dependent method. Laser Doppler perfusion imaging (LDPI) was tested to support omPT in Ni allergic contact mucositis diagnosis. Group A: 22 patients with intestinal/systemic symptoms related to the ingestion of Ni-containing foods. Group B: 12 asymptomatic volunteers. Ni-related symptoms and their severity were tested by a questionnaire. All patients underwent Ni omPT with clinical evaluation at baseline (T0), after 30 min (T1), after 2 h (T2), and after 24-48 h (T3). LDPI was performed to evaluate the mean mucosal perfusion at T0, T1, and T2. Statistical analysis was performed by ANOVA test and Bonferroni multiple-comparison test. All 22 Ni-sensitive patients (group A) presented oral mucosa hyperemia and/or edema at T2. Eight out of the same 22 patients presented a local delayed vesicular reaction at T3 (group A1), unlike the remaining 14 out of 22 patients (group A2). All 12 patients belonging to control group B did not show any alteration. The mean mucosal perfusion calculated with LDPI showed an increase in both subgroups A1 and A2. In group B, no significant perfusion variations were observed. LDPI may support omPT for diagnostic purposes in Ni allergic contact mucositis. This also applies to symptomatic Ni-sensitive patients without aphthous stomatitis after 24-48 h from omPT and that could risk to miss the diagnosis.

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“…Endothelial dysfunction, microvascular damage, and macrovascular damage are the hallmarks of SSc (1,2). Patients with SSc are at high risk for the development of ischemic digital ulcers (DUs), which occur in 35-60% of SSc patients (3).…”

Section: Introductionmentioning

confidence: 99%

Increased Intrarenal Arterial Stiffness May Predict the Occurrence of New Digital Ulcers in Systemic Sclerosis

Rosato

Barbano

Gigante

et al. 2014

Arthritis Care & Research

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In systemic sclerosis macrovascular damage of hands digital arteries correlates with microvascular damage

Cited by 55 publications

References 28 publications

Combination of Capillaroscopic and Ultrasonographic Evaluations in Systemic Sclerosis: Results of a Cross‐Sectional Study

Combination of Capillaroscopic and Ultrasonographic Evaluations in Systemic Sclerosis: Results of a Cross‐Sectional Study

Nickel-Related Intestinal Mucositis in IBS-Like Patients: Laser Doppler Perfusion Imaging and Oral Mucosa Patch Test in Use

Increased Intrarenal Arterial Stiffness May Predict the Occurrence of New Digital Ulcers in Systemic Sclerosis

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