In-source collision induced dissociation study of polyethers cationized by alkali metal ions

Kuki, Ákos; Irsai, Izabella; Nagy, Lajos; Shemirani, Ghazaleh; Majdik, Cornelia; Zsuga, Miklós; Kéki, Sándor

doi:10.1016/j.ijms.2012.10.004

Cited by 10 publications

(10 citation statements)

References 21 publications

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“…Therefore, such interactions in the gas phase have been widely studied for a number of the complexes, eg, for complexes of amino acids, nucleobases, or crown ethers . Complexes of polyethylene glycols (PEGs, linear analogs of crown ether) and related compounds with metal cations have been already widely studied . However, the hydration of PEG‐metal cation complexes has not been studied yet.…”

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confidence: 99%

“…[11][12][13] Complexes of polyethylene glycols (PEGs, linear analogs of crown ether) and related compounds with metal cations have been already widely studied. [14][15][16][17][18][19][20][21][22] However, the hydration of PEG-metal cation complexes has not been studied yet.Usually, in order to study the gas phase interaction between water molecules (or other solvent molecule), the use of a specially designed mass spectrometer is required. However, sometimes the interaction between ions and water, which is present as an impurity Journal of MASS SPECTROMETRY 90 JMS LETTERS Journal of MASS SPECTROMETRY molecule attachment occurs in the order [PEG n -H + Mg] + > [PEG n -H + Ca] + > [PEG n -H + Sr] + , and for [PEG n -H + Mg] + ions, we deal with attachment of two water molecules ( Figure 2).…”

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confidence: 99%

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confidence: 99%

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Gas phase hydration of polyethylene glycol–metal cation complexes

Frański

2018

J Mass Spectrom

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confidence: 99%

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confidence: 99%

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Gas phase hydration of polyethylene glycol–metal cation complexes

Frański

2018

J Mass Spectrom

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“…This maybe connected to the fragmentation within the cryptand moiety. Such elimination was described as characteristic for the PEG compounds . In the case of peptide conjugates with cryptands containing shorter ethoxyethyl bridge within the cryptand molecule (cryptands 211 and 221), the signals corresponding to the C 4 H 8 O 2 group elimination possess lower intensities.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and mass spectrometry analysis of quaternary cryptando-peptidic conjugates

et al. 2015

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The bicyclic amines in the form of cryptands, the crown ether analogs, were used in the synthesis of cryptando-peptidic conjugates with simultaneous formation of quaternary ammonium nitrogen moiety. A series of model cryptando-peptidic conjugates at the peptide N-terminus was efficiently prepared by the standard Fmoc solid phase synthesis. Tandem mass spectrometric analysis of the obtained conjugates has shown the specific fragmentation pattern during MS/MS experiment. The obtained cryptandic quaternary ammonium group undergoes the Hofmann elimination during collision-induced dissociation fragmentation followed by the ethoxyl group elimination. The presented quaternization of cryptands by iodoacetylated peptides is relatively easy and compatible with standard solid-phase peptide synthesis. Additionally, the applicability of such peptide derivatives and their isotopologues selectively deuterated at the α-carbon in the quantitative LC-MS analysis was analyzed.

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“…Conventional CAD occurred in an ion trap MS requires multiple isolation/fragmentation steps for the complete dealkylation of alkyl aromatics, which is not practical for the analysis of complex mixtures. In contrast, in‐source CAD (ISCAD) was demonstrated capable of performing near‐complete dealkylation by cleavage of multiple alkyl chains from ions of alkyl aromatic compounds in one fragmentation event …”

Section: Introductionmentioning

confidence: 99%

A Novel Evaluation Method Developed for the Denitrogenation and Deoxygenation on Molecules in Coal during Catalytic Treatments

et al. 2019

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In‐depth understanding of coal conversion processes is a key step for clean and efficient utilization of coals in chemical industry. Currently, most analytic methods aim to evaluate heteroatom release on the entire molecules. However, the production of value‐added chemicals from complex mixtures like coals are technically demanding which inevitably requires in‐depth fundamental knowledge of the treatment processes for coals. In‐source collision‐activated dissociation (ISCAD), a mass spectrometric method, can obtain details of aromatic cores and was employed in this work to provide in‐depth understanding of the catalytic conversion process of a low‐rank coal under different solvent conditions. Different heteroatom release patterns on aromatic and alkyl locations were observed for the solvents. Each solvent exhibited a characteristic preference over deoxygenation/denitrogenation on aromatic versus alkyl positions. Such preference is important for developing a desired catalytic treatment for a targeted heteroatom release. Overall, this study provides novel insights in catalytic heteroatom release processes during coal conversion that may be critical for the production of value‐added chemicals from coals.

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In-source collision induced dissociation study of polyethers cationized by alkali metal ions

Cited by 10 publications

References 21 publications

Gas phase hydration of polyethylene glycol–metal cation complexes

Gas phase hydration of polyethylene glycol–metal cation complexes

Synthesis and mass spectrometry analysis of quaternary cryptando-peptidic conjugates

A Novel Evaluation Method Developed for the Denitrogenation and Deoxygenation on Molecules in Coal during Catalytic Treatments

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