In-Situ Visualization for 3D Agent-Based Vocal Fold Inflammation and Repair Simulation

Seekhao, Nuttiiya; JáJá, Joseph F.; Mongeau, Luc; Li‐Jessen, Nicole Y. K.

doi:10.14529/jsfi170304

Cited by 5 publications

(4 citation statements)

References 31 publications

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“…Results showed that, looking at the entire simulation area, enough visual information was retained by using a fixed 6 3 sampling window. However, if the user needed to zoom in to highly active areas, a more sophisticated adaptive sampling technique could be used instead of the fixed sampling used here (Seekhao et al, 2017 ).…”

Section: Resultsmentioning

confidence: 99%

“…Those works are necessary to improve the biological representation of the VF-ABM for the ultimate clinical application. High-performance techniques are being expanded to facilitate more complex data explorations such as active area resolution enhancement (Seekhao et al, 2017 ), 3D volume rendering of ECM protein content, tissue fiber orientation and structure, while still maintaining real-time performance. This work focuses on the application of surgical vocal fold injury and repair because the empirical data (Lim et al, 2006 ; Welham et al, 2008 ) are available for model verification.…”

Section: Discussionmentioning

confidence: 99%

“…Most of these strategies were able to reduce the disk loads, but still required disk storage for the remaining essential data. In the present work, similar to (Seekhao et al, 2016 , 2017 ), VirtualGL was employed as a tool for developing in situ visualization of an ABM that circumvents disk storage and directly visualize simulated outputs written on to a RAM. This real-time visualization feature would assist researchers in tracking the progress and steering the course of the simulation.…”

Section: Introductionmentioning

confidence: 99%

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High-Performance Agent-Based Modeling Applied to Vocal Fold Inflammation and Repair

et al. 2018

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Fast and accurate computational biology models offer the prospect of accelerating the development of personalized medicine. A tool capable of estimating treatment success can help prevent unnecessary and costly treatments and potential harmful side effects. A novel high-performance Agent-Based Model (ABM) was adopted to simulate and visualize multi-scale complex biological processes arising in vocal fold inflammation and repair. The computational scheme was designed to organize the 3D ABM sub-tasks to fully utilize the resources available on current heterogeneous platforms consisting of multi-core CPUs and many-core GPUs. Subtasks are further parallelized and convolution-based diffusion is used to enhance the performance of the ABM simulation. The scheme was implemented using a client-server protocol allowing the results of each iteration to be analyzed and visualized on the server (i.e., in-situ) while the simulation is running on the same server. The resulting simulation and visualization software enables users to interact with and steer the course of the simulation in real-time as needed. This high-resolution 3D ABM framework was used for a case study of surgical vocal fold injury and repair. The new framework is capable of completing the simulation, visualization and remote result delivery in under 7 s per iteration, where each iteration of the simulation represents 30 min in the real world. The case study model was simulated at the physiological scale of a human vocal fold. This simulation tracks 17 million biological cells as well as a total of 1.7 billion signaling chemical and structural protein data points. The visualization component processes and renders all simulated biological cells and 154 million signaling chemical data points. The proposed high-performance 3D ABM was verified through comparisons with empirical vocal fold data. Representative trends of biomarker predictions in surgically injured vocal folds were observed.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High-Performance Agent-Based Modeling Applied to Vocal Fold Inflammation and Repair

et al. 2018

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“…Autonomous movement systems are mobile machines capable of communicating with the environment and performing various tasks without human intervention [1], [2]. In mobile robotics, the robot can be moved from one point to another automatically in a way called autonomous navigation [3].…”

Section: Introductionmentioning

confidence: 99%

Path discovering in maze area using mobile robot

et al. 2022

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Robotic maze pathfinding problems deal with detecting the correct route from the start point to the end-point in a virtual maze environment consisting of walls. Automated robot mobility is a significant feature, which enables a mobile robot to traverse a maze independently, from one position to another, without human intervention. There is a myriad of autonomous industrial mobile robot applications, including the transportation of goods and parts, domestic cleaning, indoor security surveillance, airport baggage couriering, and a plethora of other applications to traverse dangerous locations. This paper proposes a pathfinding mobile robot in a virtual maze based on a combination of a simplified left-hand algorithm and a line-following control algorithm. The mobile robot works in any maze to determine a route from the initial starting point to the end-point. The approach outlined in this paper uses a left-hand algorithm to solve the maze problem and a line-follower control algorithm to enable the robot to move in a straight line through the virtual maze. The algorithm used is less complicated and prevents the robot from falling into infinity loops compared to the traditional wall-follower algorithm.

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Progress in Vocal Fold Regenerative Biomaterials: An Immunological Perspective

Coburn

et al. 2021

Advanced NanoBiomed Research

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The vocal folds are functional organs located in the larynx that play a critical role in our daily breathing, speech, and swallowing functions. A key structural feature of the vocal folds is their delicate mucosa, which consists of a thin, layered epithelium and underlying extracellular matrix (ECM)-rich lamina propria. [1,2] Irreversible changes to the vocal fold mucosa, such as scarring, atrophy, and sulcus vocalis, require regenerative technologies to stimulate a controlled regrowth of the tissue. An increasing number of biomaterial systems have been proposed with the concurrent capability of refilling and regenerating severely damaged or absent vocal fold mucosae in situ (see review on public health significance in the study by Green et al. [3] ).Notably, as the vocal folds are located at the narrowest point of the airway, adverse hostÀbiomaterial responses can impair upper airway patency and create life-threatening complications. For instance, 2À5% of patients were reported to have postoperative inflammatory reactions including edema, dysphonia, and dyspnea to injectable biomaterials derived from hyaluronic acid (HA). [4][5][6] Although the incidence is rare, severe airway reactions could lead to an emergency admission for intensive care and require intubation procedures for breathing support. [5,7] Inevitably, this immunemediated rejection response is detrimental to the longevity, performance, and integration of the biomaterial in the vocal fold mucosa.Upon biomaterial introduction into a host, the immune system quickly responds to the iatrogenic trauma and foreign

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In-Situ Visualization for 3D Agent-Based Vocal Fold Inflammation and Repair Simulation

Cited by 5 publications

References 31 publications

High-Performance Agent-Based Modeling Applied to Vocal Fold Inflammation and Repair

High-Performance Agent-Based Modeling Applied to Vocal Fold Inflammation and Repair

Path discovering in maze area using mobile robot

Progress in Vocal Fold Regenerative Biomaterials: An Immunological Perspective

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