In situ time-resolved X-ray diffraction study of octacalcium phosphate transformations under physiological conditions

Rau, Julietta V.; Komlev, V. S.; Generosi, Amanda; Fosca, Marco; Albertini, V. Rossi; Баринов, С. М.

doi:10.1016/j.jcrysgro.2010.03.044

Cited by 10 publications

(7 citation statements)

References 19 publications

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“…In this inset, an increase and a decrease of specific Bragg reflection relative areas, and namely the increase of the (321) peak and the decrease of the (121) and (021) peaks, is evident. Similar inverse trends have been observed in our previous study on OCP in physiological solution . In that work, the loss of the (021) peak relative area was registered, whereas the (321) peak relative area increased.…”

Section: Resultssupporting

confidence: 90%

“…74-0566). The (021) peak behavior can be considered as representative of OCP only: its relative area decreases, as was ascertained in our earlier work, due to the conversion of octacalcium phosphate into HA.…”

Section: Resultsmentioning

confidence: 67%

“…74-0566 29 ). The (021) peak behavior can be considered as representative of OCP only: its relative area decreases, as was ascertained in our earlier work, 33 due to the conversion of octacalcium phosphate into HA. To confirm this hypothesis, that is, that the inverse peak behavior is due to the HA formation, a different q-region was explored during ex situ EDXRD measurements, analyzing the final paste.…”

Section: Resultsmentioning

confidence: 67%

“…Similar inverse trends have been observed in our previous study on OCP in physiological solution. 33 In that work, the loss of the (021) peak relative area was registered, whereas the (321) peak relative area increased. Indeed, the (021) peak can be associated to the OCP crystalline structure only (there is no overlap with HA reflections at q = 1.68 A ˚-1 ), while the (321) reflection at q = 2.21 A ˚-1 is the convolution of the (321) OCP peak and the (211) 100% relative intensity HA peak at q = 2.24 A ˚-1 (hexagonal system, S.G. P63/m (176), card no.…”

Section: Resultsmentioning

confidence: 76%

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In Situ Time-Resolved Studies of Octacalcium Phosphate and Dicalcium Phosphate Dihydrate in Simulated Body Fluid: Cooperative Interactions and Nanoapatite Crystal Growth

Rau

Fosca

Komlev

et al. 2010

Crystal Growth & Design

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The present study is focused on the in vitro study of the biphasic octacalcium phosphate (OCP)−dicalcium phosphate dihydrate (DCPD) system transformations in simulated body fluid (SBF) for possible applications as bone substitute materials. The aim of this paper is to outline the role of the additional component DCPD during a transformation/crystallization processes. Energy dispersive X-ray diffraction and FTIR spectroscopy techniques were used for in situ monitoring of the processes taking place in the system in real time. Morphological investigations were performed applying the scanning electron microscopy technique. Several OCP−DCPD combinations were investigated: (1) 100% OCP; (2) 70% OCP−30% DCPD; (3) 100% DCPD. The obtained experimental results allowed us to conclude that when only OCP is present in SBF, the formation of carbonated hydroxyapatite takes place, whereas for the OCP−DCPD (30%) system in SBF, less kinetically favorable hydroxyapatite (HA) is formed. The additional component (DCPD) influences significantly the structural behavior of hydroxyapatite, acting as the HA crystallization inhibition agent. By means of this approach, allowing for the control of the HA crystallization, the calcium phosphate based biomaterials can be suitably modified for implant use in bone tissue engineering. The results obtained in this work provided some insights into the biomineralization mechanism.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 67%

Section: Resultsmentioning

confidence: 67%

Section: Resultsmentioning

confidence: 76%

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In Situ Time-Resolved Studies of Octacalcium Phosphate and Dicalcium Phosphate Dihydrate in Simulated Body Fluid: Cooperative Interactions and Nanoapatite Crystal Growth

Rau

Fosca

Komlev

et al. 2010

Crystal Growth & Design

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“…Also, in this case, only a slight grain size growth takes place, starting from 4.0 ± 1.0 nm up to 6.0 ± 1.0 nm. Both processes, the OCP conversion into HA or CHA and the OCP crystallization, can take place with the same characteristic time (1.0 ± 0.5 h) [31].…”

Section: Resultsmentioning

confidence: 99%

Phase Development During Setting and Hardening of a Bone Cement Based on α-Tricalcium and Octacalcium Phosphates

et al. 2011

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In this study, the phase development in the cement system α-TCP-OCP with phosphoric acid as a setting liquid was studied. The most promising formulation of α-TCP (60 wt%) and OCP (40 wt%) is proposed. This cement has the following characteristics: setting time 10 min, pH = 6.7, the compressive strength about 30 MPa, and high dissolution rate in an isotonic solution; the final wt% composition of α-TCP/DCPD/HA/OCP equals 27/38/20/15. Energy dispersive X-ray diffraction techniques were used for in situ monitoring of the processes taking place in the cement in real time.

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Recent Advances in Research Applications of Nanophase Hydroxyapatite

2012

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Hydroxyapatite, the main inorganic material in natural bone, has been used widely for orthopaedic applications. Due to size effects and surface phenomena at the nanoscale, nanophase hydroxyapatite possesses unique properties compared to its bulk-phase counterpart. The high surface-to-volume ratio, reactivities, and biomimetic morphologies make nano-hydroxyapatite more favourable in applications such as orthopaedic implant coating or bone substitute filler. Recently, more efforts have been focused on the possibility of combining hydroxyapatite with other drugs and materials for multipurpose applications, such as antimicrobial treatments, osteoporosis treatments and magnetic manipulation. To build more effective nano-hydroxyapatite and composite systems, the particle synthesis processes, chemistry, and toxicity have to be thoroughly investigated. In this Minireview, we report the recent advances in research regarding nano-hydroxyapatite. Synthesis routes and a wide range of applications of hydroxyapatite nanoparticles will be discussed. The Minireview also addresses several challenges concerning the biosafety of the nanoparticles.

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In situ time-resolved X-ray diffraction study of octacalcium phosphate transformations under physiological conditions

Cited by 10 publications

References 19 publications

In Situ Time-Resolved Studies of Octacalcium Phosphate and Dicalcium Phosphate Dihydrate in Simulated Body Fluid: Cooperative Interactions and Nanoapatite Crystal Growth

In Situ Time-Resolved Studies of Octacalcium Phosphate and Dicalcium Phosphate Dihydrate in Simulated Body Fluid: Cooperative Interactions and Nanoapatite Crystal Growth

Phase Development During Setting and Hardening of a Bone Cement Based on α-Tricalcium and Octacalcium Phosphates

Recent Advances in Research Applications of Nanophase Hydroxyapatite

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