In situ thermal ablation of tumors in combination with nano-adjuvant and immune checkpoint blockade to inhibit cancer metastasis and recurrence

Han, Xiao; Wang, Rui; Xu, Jun; Chen, Qian; Liang, Chao; Chen, Jiawen; Zhao, Jing; Chu, Jiacheng; Fan, Qin; Archibong, Edikan; Jiang, Lixin; Wang, Chao; Liu, Zhuang

doi:10.1016/j.biomaterials.2019.119490

Cited by 68 publications

(62 citation statements)

References 38 publications

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“…This excellent anti-tumor e ciency is consistent with the excellent tumor inhibition e ciency and effective immune activation ability of DDP NP DOX&R848 in K7M2 tibio bular osteosarcoma mouse model. Then, we analysed the ability of DDP NP DOX&R848 to evoke immune memory by effector memory T (T EM ) cells quanti cation [42]. As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Hyaluronate-based Self-stabilized Nanoparticles for Reverting Immunosuppression and Immunochemotherapy in Osteosarcoma Treatment 

Zhang¹,

Yuan²,

Li³

et al. 2020

Preprint

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Background: Chemotherapy and immunotherapy are the mainly non-surgical treatment for osteosarcoma in clinic presently. However, serious side effects, short blood circulation time, and immunosuppressive tumor microenvironment have extremely limited their application. To generate an onsite combined chemotherapy and immunotherapy regimen, we designed a self-stabilized hyaluronic acid (HA) nanoparticle for the tumor-targeting delivery of doxorubicin (DOX), cisplatin (DDP), and resiquimod (R848) in osteosarcoma treatment, referred to as DDPNPDOX&R848. Methods: Here, we tested the physicochemical properties of and the ability of DDPNPDOX&R848 to induce immunogenic cell death (ICD) and revert immunosuppressive cells were characterized in vitro. The therapeutic efficacy of DDPNPDOX&R848 in vivo was evaluated in an orthotopic osteosarcoma mouse model. Furthermore, we also verified the immune memory evoking effect of DDPNPDOX&R848 in an osteosarcoma rechanllenge mouse model.Results: DDPNPDOX&R848 possesses a uniform size (similar to 190 nm) and ideal pH responsibility, and its ability to induce ICD and modulate immune cells was also proven. In vivo, regardless of the mouse model used (i.e., orthotopic osteosarcoma or rechanllenge xenografted osteosarcoma), DDPNPDOX&R848 showed significantly enhanced tumor inhibition and prolonged survival. Evoked tumoricidal immune memory responses were also demonstrated in the rechanllenged osteosarcoma mouse model.Conclusion: In summary, this intelligent codelivery platform might be a competitive candidate for osteosarcoma immunochemotherapy.

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Section: Resultsmentioning

confidence: 99%

Hyaluronate-based Self-stabilized Nanoparticles for Reverting Immunosuppression and Immunochemotherapy in Osteosarcoma Treatment 

Zhang¹,

Yuan²,

Li³

et al. 2020

Preprint

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“…In addition to the above two models of HTT, Liu et al also used radiofrequency and highintensity focused ultrasound for the hyperthermal ablation of tumors; however, the high therapeutic power and frequency caused severe damage to the surrounding healthy tissue. [144] By synergistically combining HTT with other treatment approaches, such as PDT, CDT, nanozyme catalytic ROS augmentation, chemotherapy, ion interference therapy, or starvation therapy, the antitumor effects and the stimulated immune responses could be significantly enhanced. Further combination with immunotherapy could also achieve admirable therapeutic outcomes including tumor elimination, cancer metastasis/recurrence inhibition, and prolonged survival.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

et al. 2020

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Figure 3. a) Schematic illustration of the PTT-assisted immunotherapy. b) PD-L1 expression on 4T1 tumor cells after different treatments. c) Flow cytometric examination of the intratumor infiltration of CD4 + and CD8 + T cells. d,e) The primary and distal tumor growth curves of 4T1 tumor-bearing mice. f) Quantification of pulmonary metastasis nodules in different groups of 4T1 tumor-bearing mice. g) The tumor growth curves of B16F10-bearing mice model (*p < 0.05, **p < 0.01, ***p < 0.001). Reproduced with permission. [52] Copyright 2019, Nature Research.

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“…According to previous reports, the local amplified oxidative stress (i.e., ROS-induced inflammation) could activate immune systems; however, some immune suppressive cells such as regulatory T (T reg ) cells also could be activated. [34,35] Hence, checkpoint inhibitor anti-CTLA-4 was employed to amplify the anti-tumor immune responses induced by FeWO X -PEG bioreactors. 4T1-tumor bearing mice were divided into four groups (n = 5 per group): 1) control; 2) anti-CTLA-4 (intravenous (i.v.)…”

Section: (5 Of 13)mentioning

confidence: 99%

Bimetallic Oxide FeWO_X Nanosheets as Multifunctional Cascade Bioreactors for Tumor Microenvironment‐Modulation and Enhanced Multimodal Cancer Therapy

Gong

Chen

Yang

et al. 2020

Adv Funct Materials

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Modulating the hostile tumor microenvironment (TME) rather than directly killing cancer cells may be an effective strategy to improve the therapeutic benefits in cancer treatment. Herein, FeWO X nanosheets are constructed as cascade bioreactors to modulate the TME and enhance radiotherapy and immunotherapy of tumors. Synthesized by the thermaldecomposition method and modified by poly(ethylene glycol) (PEG), the obtained FeWO X-PEG with multivalent metal elements (Fe 2+/3+ , W 5+/6+) exhibit efficient catalytic decomposition of hydrogen peroxide (H 2 O 2) to generate hydroxyl radicals (•OH) for chemo-dynamic therapy (CDT). The generated high valence of metal ions (Fe 3+ /W 6+) in FeWO X-PEG are reduced by endogenous glutathione (GSH), both leading to depletion of GSH and further amplified oxidative stress, and resulting in the reduced metal valence statuses (Fe 2+ /W 5+) enabling cascade bioreactions. Such FeWO X-PEG bioreactors enhance the oxidative stress in the tumor and interact with X-rays, significantly improving cancer radiotherapy (RT). Furthermore, the reactive oxygen species (ROS)-induced inflammation caused by FeWO X-PEG in TME activates the immune system and promotes the tumor-infiltration of various types of immune cells, which working together with cytotoxic T-lymphocyte antigen-4 (CTLA-4) checkpoint blockade could elicits a robust immune response to defeat tumors.

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In situ thermal ablation of tumors in combination with nano-adjuvant and immune checkpoint blockade to inhibit cancer metastasis and recurrence

Cited by 68 publications

References 38 publications

Hyaluronate-based Self-stabilized Nanoparticles for Reverting Immunosuppression and Immunochemotherapy in Osteosarcoma Treatment

Hyaluronate-based Self-stabilized Nanoparticles for Reverting Immunosuppression and Immunochemotherapy in Osteosarcoma Treatment

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Bimetallic Oxide FeWO_X Nanosheets as Multifunctional Cascade Bioreactors for Tumor Microenvironment‐Modulation and Enhanced Multimodal Cancer Therapy

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In situ thermal ablation of tumors in combination with nano-adjuvant and immune checkpoint blockade to inhibit cancer metastasis and recurrence

Cited by 68 publications

References 38 publications

Hyaluronate-based Self-stabilized Nanoparticles for Reverting Immunosuppression and Immunochemotherapy in Osteosarcoma Treatment&nbsp;

Hyaluronate-based Self-stabilized Nanoparticles for Reverting Immunosuppression and Immunochemotherapy in Osteosarcoma Treatment&nbsp;

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Bimetallic Oxide FeWOX Nanosheets as Multifunctional Cascade Bioreactors for Tumor Microenvironment‐Modulation and Enhanced Multimodal Cancer Therapy

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Hyaluronate-based Self-stabilized Nanoparticles for Reverting Immunosuppression and Immunochemotherapy in Osteosarcoma Treatment

Hyaluronate-based Self-stabilized Nanoparticles for Reverting Immunosuppression and Immunochemotherapy in Osteosarcoma Treatment

Bimetallic Oxide FeWO_X Nanosheets as Multifunctional Cascade Bioreactors for Tumor Microenvironment‐Modulation and Enhanced Multimodal Cancer Therapy