In Situ Synthesized Selenium Nanoparticles‐Decorated Bacterial Cellulose/Gelatin Hydrogel with Enhanced Antibacterial, Antioxidant, and Anti‐Inflammatory Capabilities for Facilitating Skin Wound Healing

Abstract

Bacterial-associated wound infection and antibiotic resistance have posed a major burden on patients and health care systems. Thus, developing a novel multifunctional antibiotic-free wound dressing that cannot only effectively prevent wound infection, but also facilitate wound healing is urgently desired. Herein, a series of multifunctional nanocomposite hydrogels with remarkable antibacterial, antioxidant, and anti-inflammatory capabilities, based on bacterial cellulose (BC), gelatin (Gel), and selenium nanoparticles (SeNPs), are constructed for wound healing application. The BC/Gel/SeNPs nanocomposite hydrogels exhibit excellent mechanical properties, good swelling ability, flexibility and biodegradability, and favorable biocompatibility, as well as slow and sustainable release profiles of SeNPs. The decoration of SeNPs endows the hydrogels with superior antioxidant and anti-inflammatory capability, and outstanding antibacterial activity against both common bacteria (E. coli and S. aureus) and their multidrug-resistant counterparts. Furthermore, the BC/Gel/SeNPs hydrogels show an excellent skin wound healing performance in a rat full-thickness defect model, as evidenced by the significantly reduced inflammation, and the notably enhanced wound closure, granulation tissue formation, collagen deposition, angiogenesis, and fibroblast activation and differentiation. This study suggests that the developed multifunctional BC/Gel/SeNPs nanocomposite hydrogel holds a great promise as a wound dressing for preventing wound infection and accelerating skin regeneration in clinic.

The Trend of Bacterial Nanocellulose Research Published in the Science Citation Index Expanded From 2005 to 2020: A Bibliometric Analysis

“…Innovatec and Axcelon Dermacare Inc., are two other firms that have announced their BNC vascular graft-based device tubing ( Czaja et al, 2007 ; Portela et al, 2019 ). Furthermore, Mao, Lin et al devised hydrogel by in-situ synthesis of selenium nanoparticles coated with BC/gelatin which represents increased antibacterial, antioxidant, and anti-inflammatory properties to aid skin wound healing ( Mao et al, 2021 ). Figures 8 , 9 exhibit typical applications of BNC in biomedical field.…”

Development and Characterization of Yeast-Incorporated Antimicrobial Cellulose Biofilms for Edible Food Packaging Application

“…These results further demonstrate that the BC/CMC/Gly/yeast composite film possesses antibacterial activity against both Gram-positive ( S. aureus ) and Gram-negative bacteria ( P. aeruginosa and E. coli ). Previous studies have reported that both pristine BC [ 26 ] and CMC [ 64 ] do not possess any antibacterial activities, and these only show antibacterial activity when composited with other bactericidal elements such as metal nanoparticles [ 75 , 76 ], antimicrobial peptides [ 77 ], and some polymers such as chitosan [ 78 ]. Similarly, Gly is only used as the carbon source by different microorganisms and does not demonstrate any antibacterial activity [ 79 ].…”

Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications

“…4.1.5. Bacterial Cellulose Based Self-Healing Hydrogel for Wound Healing Bacterial cellulose is an excellent hydrogel system used for wound healing, drug delivery, and tissue engineering applications [107][108][109]. Khamrai et al developed a bioderived self-healing wound healing patch made of curcumin loaded onto gelatin and ionically modified bacterial cellulose composite.…”