In situ synthesis of copper metal-organic framework on paper-based device for dual-mode detection of volatile sulfur compounds in exhaled breath

Hou, Yue; Lv, Congcong; Liu, Wei; Guo, Yanli; Jin, Yan; Li, Baoxin; Zhang, Yu; Liu, Yuchuan

doi:10.1016/j.snb.2021.131008

Cited by 21 publications

(6 citation statements)

References 55 publications

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“…The morphology of Cu-MOF-74 crystal looked like a unidirectional bouquet with hexagonal segments (Figure A), which confirmed to the hexagonal system . The same morphology on the paper substrate was obtained by the ring-oven-assisted method (Figure B) and the in situ solvothermal method (Figure C), but the ring-oven-assisted method offered less time and precursors. To prove the applicability of the ring-oven-assisted method on paper, a glass fiber was attempted to be used as the substrate (Cu-MOF-74@glass fiber).…”

Section: Resultssupporting

confidence: 64%

Ring-Oven-Assisted In Situ Synthesis of Metal–Organic Frameworks on the Lab-On-Paper Device for Chemiluminescence Detection of Nitrite in Whole Blood

Hou

Guo

et al. 2023

Anal. Chem.

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In situ synthesis of metal–organic frameworks (MOFs) on flexible materials for the fabrication of functional platforms and micro-devices is challenging. The time-/precursor-consuming procedure and uncontrollable assembly are stumbling blocks for constructing this platform. Herein, a novel in situ MOF synthesis method on paper substrates by use of the ring-oven-assisted technique was reported. Utilizing the ring-oven’s heating and washing function, MOFs can be synthesized in 30 min on the designated position of paper chips with extremely low-volume precursors. The principle of this method was explained by steam condensation deposition. The MOFs’ growth procedure was theoretically calculated by crystal sizes and the results conformed to the Christian equation. As different MOFs (Cu-MOF-74, Cu-BTB, Cu-BTC) can be synthesized successfully on paper-based chips, the ring-oven-assisted in situ synthesis method has great generality. Then, the prepared Cu-MOF-74 loading paper-based chip was applied to the chemiluminescence (CL) detection of nitrite (NO2 –), based on the catalysis effect of Cu-MOF-74 on the NO2 ––H2O2 CL system. Also, by the delicate design of the paper-based chip, NO2 – can be detected with the detection limit (DL) of 0.5 nM in whole blood samples without sample pretreatment. This work establishes a distinctive method for the in situ synthesis of MOFs and the application of MOFs on paper-based CL chips.

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Section: Resultssupporting

confidence: 64%

Ring-Oven-Assisted In Situ Synthesis of Metal–Organic Frameworks on the Lab-On-Paper Device for Chemiluminescence Detection of Nitrite in Whole Blood

Hou

Guo

et al. 2023

Anal. Chem.

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“…First, the designed Zn-Py-TPE@paper was put into a Teflon bag, which had a cutting incision in advance. Then, the incision was sealed, and the bag was pumped to drive out the air . Next, the above prepared FA standard gas of required concentration was transferred into this bag.…”

Section: Methodsmentioning

confidence: 99%

Tetrakis(4-pyridylphenyl)ethylene-based Zinc Metal–Organic Framework with Aggregation-Induced Chemiluminescence Emission on a Paper Platform for Formaldehyde Detection in Breath

Guo

Hou

et al. 2022

Anal. Chem.

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Volatile formaldehyde (FA) in exhaled breath (EB) is considered as a biomarker for lung cancer (LC). On-the-spot selective and sensitive detection of gaseous FA is rather important for LC screening and diagnosis. Herein, a tetrakis(4-pyridylphenyl)ethylene (Py-TPE)-based zinc metal–organic framework (MOF) with excellent aggregation-induced emission (AIE) property was utilized for absorption and selective detection of FA in EB. The porous Zn-Py-TPE served as a gaseous confinement cavity for the adsorption of FA in EB. Interestingly, Zn-Py-TPE was aggregated on paper, and then aggregation-induced chemiluminescence (CL) emission can be triggered by only adding bis(2,4,6-trichlorophenyl)oxalate (TCPO). Though without H2O2, the CL of Zn-Py-TPE-TCPO was enhanced greatly by FA. FA promoted the aggregation of Zn-Py-TPE on paper by forming halogen bonding between FA and Zn-Py-TPE, which contributed to the better selectivity. FA can also stimulate the production of more singlet oxygen (1O2) in the Zn-Py-TPE-TCPO CL system. Hence, FA could be detected via the proposed Zn-Py-TPE-TCPO system with a quantification linear range of 1.0–100.0 ppb and detection limit of 0.3 ppb. This portable, low-cost, and sensitive paper-based platform can achieve trace FA detection in EB and is expected to provide an on-the-spot screening platform for lung cancer.

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“…Paper has been considered as an ideal flexible substrate for sensing materials immobilization, because of low cost and good chemical compatibility. 41 Combination of paper based devices with MOFs could be a promising alternative to build a composite taking profit from the permeability and simplicity of the cellulosic paper and capturing the performance of the MOFs. 42,43 In recent years, The application of MOFs to design paper-based analytical devices has been reported by a few research groups for various applications.…”

Section: Introductionmentioning

confidence: 99%

A novel ratiometric design of microfluidic paper-based analytical device for the simultaneous detection of Cu²⁺ and Fe³⁺ in drinking water using a fluorescent MOF@tetracycline nanocomposite

Al-Jaf,

Mohammed Ameen,

Omer

2024

Lab Chip

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In situ synthesis of copper metal-organic framework on paper-based device for dual-mode detection of volatile sulfur compounds in exhaled breath

Cited by 21 publications

References 55 publications

Ring-Oven-Assisted In Situ Synthesis of Metal–Organic Frameworks on the Lab-On-Paper Device for Chemiluminescence Detection of Nitrite in Whole Blood

Ring-Oven-Assisted In Situ Synthesis of Metal–Organic Frameworks on the Lab-On-Paper Device for Chemiluminescence Detection of Nitrite in Whole Blood

Tetrakis(4-pyridylphenyl)ethylene-based Zinc Metal–Organic Framework with Aggregation-Induced Chemiluminescence Emission on a Paper Platform for Formaldehyde Detection in Breath

A novel ratiometric design of microfluidic paper-based analytical device for the simultaneous detection of Cu²⁺ and Fe³⁺ in drinking water using a fluorescent MOF@tetracycline nanocomposite

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In situ synthesis of copper metal-organic framework on paper-based device for dual-mode detection of volatile sulfur compounds in exhaled breath

Cited by 21 publications

References 55 publications

Ring-Oven-Assisted In Situ Synthesis of Metal–Organic Frameworks on the Lab-On-Paper Device for Chemiluminescence Detection of Nitrite in Whole Blood

Ring-Oven-Assisted In Situ Synthesis of Metal–Organic Frameworks on the Lab-On-Paper Device for Chemiluminescence Detection of Nitrite in Whole Blood

Tetrakis(4-pyridylphenyl)ethylene-based Zinc Metal–Organic Framework with Aggregation-Induced Chemiluminescence Emission on a Paper Platform for Formaldehyde Detection in Breath

A novel ratiometric design of microfluidic paper-based analytical device for the simultaneous detection of Cu2+ and Fe3+ in drinking water using a fluorescent MOF@tetracycline nanocomposite

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A novel ratiometric design of microfluidic paper-based analytical device for the simultaneous detection of Cu²⁺ and Fe³⁺ in drinking water using a fluorescent MOF@tetracycline nanocomposite