In-situ synthesis of acylated sodium alginate-g-(tetrahydrofuran5-b-polyisobutylene) terpolymer/Ag-NPs nanocomposites

Gao, Yu-Zhuang; Chang, Tian-Xiao; Wu, Yixian

doi:10.1016/j.carbpol.2019.04.087

Cited by 11 publications

(7 citation statements)

References 44 publications

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“…Sodium alginate, approved by the FDA 26 as a food-additive, is considered as noncytotoxic. 27 To investigate if degradation products formed during the sterilization process of alginate influence cell viability, the metabolic activity of NIH 3T3 cells was monitored deploying WST-1 proliferation assay with increasing alginate concentrations (Figure 4).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Sterilization Methods and Their Influence on Physicochemical Properties and Bioprinting of Alginate as a Bioink Component

et al. 2020

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Bioprinting has emerged as a valuable three-dimensional (3D) biomanufacturing method to fabricate complex hierarchical cell-containing constructs. Spanning from basic research to clinical translation, sterile starting materials are crucial. In this study, we present pharmacopeia compendial sterilization methods for the commonly used bioink component alginate. Autoclaving (sterilization in saturated steam) and sterile filtration followed by lyophilization as well as the pharmacopeia noncompendial method, ultraviolet (UV)-irradiation for disinfection, were assessed. The impact of the sterilization methods and their effects on physicochemical and rheological properties, bioprinting outcome, and sterilization efficiency of alginate were detailed. Only sterile filtration followed by lyophilization as the sterilization method retained alginate’s physicochemical properties and bioprinting behavior while resulting in a sterile outcome. This set of methods provides a blueprint for the analysis of sterilization effects on the rheological and physicochemical pattern of bioink components and is easily adjustable for other polymers used in the field of biofabrication in the future.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Sterilization Methods and Their Influence on Physicochemical Properties and Bioprinting of Alginate as a Bioink Component

et al. 2020

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“…Ag nanoparticles have been extensively used in nonaqueous conductive ink [3], hydrogen sorption and storage [4], antibacterial materials [5], bone tissue regeneration and wound repair [6,7], etc. Thus, polymer/Ag nanocomposites have widely been applied in a variety of areas, such as the microelectronics, optoelectronics, magnetic materials, catalysis, chemical sensors and biology [8][9][10]. One of the interesting studies was that of the effect of polyethylene (PE)/Ag nanocomposites on Ag ion release and antimicrobial properties by Zapata et al [11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Silver Nanoparticles on the Microstructure, Non-Isothermal Crystallization Behavior and Antibacterial Activity of Polyoxymethylene

Yicheng

Yang²,

Huang

et al. 2020

Polymers

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Silver (Ag) nanoparticles were synthesized by a facile route in the presence of oleic acid and n-propylamine. It was shown that the average primary size of the as-synthesized Ag nanoparticles was approximately 10 nm and the surface of as-synthesized Ag nanoparticles was capped with monolayer surfactants with the content of 19.6%. Based on as-synthesized Ag nanoparticles, polyoxymethylene (POM)/Ag nanocomposites were prepared. The influence of Ag nanoparticles on non-isothermal crystallization behavior of POM was investigated by differential scanning calorimetry (DSC). The Jeziorny, Jeziorny-modified Avrami, Ozawa, Liu and Mo, Ziabicki and Kissinger models were applied to analyze the non-isothermal melt crystallization data of POM/Ag nanocomposites. Results of half time (t1/2), crystallization rate parameter (CRP), crystallization rate function (K(T)), kinetic parameter (F(T)), the kinetic crystallizability at unit cooling rate (GZ) and the crystallization activation energy (∆E) were determined. Small amounts of Ag nanoparticles dispersed into POM matrix were shown to act as heterogeneous nuclei, which could enhance the crystallization rate of POM, increase the number of POM spherulites and reduce POM spherulites size. However, the higher loading of Ag nanoparticles were easily aggregated, which restrained POM crystallization to some degree. Furthermore, the POM/Ag nanocomposites showed robust antibacterial activity against Escherichia coli and Staphylococcus aureus.

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“…The living PTHF chains with a designed M n were synthesized via living CROP of THF according to our previous works. − Briefly, AgClO 4 (60 mg) and fresh THF (60 mL) were added into a clean prebaked glass tube equipped with a magnetic stir bar in an ice-water bath. Subsequently, 0.02 mL of allyl bromide was added under stirring.…”

Section: Methodsmentioning

confidence: 99%

“…The highly efficient method has been established in our group for preparing a well-defined branched polymeric structure by grafting synthetic polymer chains onto a macromolecular backbone with controlled branch length, grafting density, and extremely high grafting efficiency in the graft copolymers. − Aiming to construct the branched polymeric structure with hydrophobic flexible PTHF branches and hydrophilic hard HPC backbone as well as AgNPs through chemical modification of grafting reaction, a series of novel HPC- g -PTHF graft copolymers have been prepared by combining living CROP and nucleophile substitution reaction of electrophilic oxonium-end living PTHF chains with nucleophilicity of HPC (−OH groups along backbone) using allyl bromide/AgClO 4 as an initiating system in this investigation. This green synthetic approach will provide a highly effective process with grafting efficiency ( G E ) of ca.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis and Biomedical Properties of Novel Hydroxypropyl Cellulose-g-Polytetrahydrofuran Graft Copolymers with Silver Nanoparticles

Deng

2019

Ind. Eng. Chem. Res.

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A green approach has been developed for the synthesis of hydroxypropyl cellulose-g-polytetrahydrofuran (HPC-g-PTHF) graft copolymer via combining living cationic ring-opening polymerization and nucleophile substitution reaction. The living PTHF chains (M n = 3200 g·mol–1) were synthesized in bulk initiated by allyl bromide/AgClO4 without any other hazardous solvents. Then, the living PTHF chains reacted with hydroxyl groups on the HPC backbone with grafting efficiency of ca. 100% to create a series of HPC-g-PTHF graft copolymers with various average grafting numbers (G N). The nanosized phase separation micromorphology was dependent on G N in HPC-g-PTHF. The water contact angles on graft copolymer film surfaces increased from 61.7° to 87.7° with increasing G N from 3 to 10 and after annealing treatment. The silver nanoparticles (AgNPs) in situ formed from AgClO4 uniformly dispersed in graft copolymer matrix and Ag contents were close to the theoretical data based on AgClO4. The HPC-g-PTHF graft copolymer films show good anti-protein adsorption performance against bull serum albumin. The HPC-g-PTHF/AgNPs compounds present good antibacterial activity.

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In-situ synthesis of acylated sodium alginate-g-(tetrahydrofuran5-b-polyisobutylene) terpolymer/Ag-NPs nanocomposites

Cited by 11 publications

References 44 publications

Sterilization Methods and Their Influence on Physicochemical Properties and Bioprinting of Alginate as a Bioink Component

Sterilization Methods and Their Influence on Physicochemical Properties and Bioprinting of Alginate as a Bioink Component

Effect of Silver Nanoparticles on the Microstructure, Non-Isothermal Crystallization Behavior and Antibacterial Activity of Polyoxymethylene

Green Synthesis and Biomedical Properties of Novel Hydroxypropyl Cellulose-g-Polytetrahydrofuran Graft Copolymers with Silver Nanoparticles

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