In situ synthesis and magnetic studies of iron oxide nanoparticles in calcium-alginate matrix for biomedical applications

Morales, Marco A.; Finotelli, Priscilla Vanessa; Coaquira, J. A. H.; Rocha-Leão, Maria Helena M.; Díaz-Águila, Carlos; Baggio-Saitovitch, E.; Rossi, Antonella

doi:10.1016/j.msec.2006.12.016

Cited by 88 publications

(45 citation statements)

References 21 publications

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“…Although the saturation magnetization (M s ) of Fe 3 O 4 was 70.83 emu/g, which is higher than those of H1, H2, the magnetizations of the hydrogels are high enough for biomedical application. In addition, the M r /M s values of H1 and H2 are significantly lower than T30 and the previous studies [8,9]. In the limit of the authors' knowledge, this is the lowest M r /M s has been reported.…”

Section: Magnetization Propertiescontrasting

confidence: 71%

“…It is also observed that the very small particles (the circles in Figure 4) appeared which may be the results of iron oxide nanoparticle trapped inside the alginate matrix. Compared with the previous reports, the size of H1, H2 are of equivalent to the smallest sizes of MNPs [5,8,9]. The decrease of MNP size can be attributed to the limit of the crystal growth since the Fe (II) and Fe (III) ions are trapped inside the hydrogel matrix.…”

Section: Crystal Structure Of Materials Characterized By Xrd and Tem mentioning

confidence: 69%

“…The incorporations of magnetic nanoparticles in alginate for biomedical application were reported [5]. Generally, MNP was synthesized by coprecipitation and then loaded into alginate hydrogel [6,7] or by in-situ coprecipitation of Fe(II) and Fe (III) in the sodium-or calcium-alginate matrix [5,8]. Briefly, the particle sizes in the previous reports were varied from 5 to over 100 nm.…”

Section: Introductionmentioning

confidence: 99%

“…In detail, the particle size is smaller than 5.5 nm, MNP can be quickly removed through the renal system [7]. However, only several reports successfully synthesized MNP at this size [5,8,9]. Therefore, we studied the synthesis of iron nanoparticle which was trapped in alginate hydrogel matrix to reduce the size of iron nanoparticle and subsequently produce the magnetic hydrogel.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of Magnetic Hydrogel by in-Situ Coprecipitation Process

Nguyen¹

2018

JST

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This study describes a preparation of magnetite nanoparticle by co-precipitation of Fe(II) and Fe(III) in alginate hydrogel matrix. This simple process is sufficient for producing a superparamagnetic, well dispersible magnetite nanoparticle in polymer hydrogel matrix. Two approaches for iron ions loadings are induced. The first approach includes two steps, the hydrogel beads are formed before the iron ions are being diffused into the hydrogel matrix. The second approach is the simultaneous forming of hydrogel containing iron ions. The ions loaded hydrogel is then coprecipitated in the presence of ammonium hydroxide to afford iron oxide magnetite nanoparticles in alginate hydrogel matrix. The composition and characteristics of the hydrogel containing magnetite nanoparticle were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), vibrating sample magnetometer (VSM) and transmission electron microscopy (TEM). The results showed that the particles size of magnetic nanoparticles prepared by in-situ coprecipitation method is around ~ 6 nm and smaller than that produced by normal coprecipitation method. The magnetic hydrogel exhibits superparamagnetic properties with the saturation magnetization of about 25 emu/g, the ratio of Mr/Ms about 0.8 ×10 -3 . Possessing the biocompatibility as well as superparamagnetism, the magnetite hydrogel is a promising materials for environmental and biomedical applications.

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Section: Magnetization Propertiescontrasting

confidence: 71%

Section: Crystal Structure Of Materials Characterized By Xrd and Tem mentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation of Magnetic Hydrogel by in-Situ Coprecipitation Process

Nguyen¹

2018

JST

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“…This is an important outcome since maghemite, the product that results in this case from the oxidation of magnetite, has lower saturation magnetization than magnetite. Magnetic iron oxide nanoparticles have been also synthesized in the presence of other polysaccharides such as starch (D. K. Kim et al, 2003), alginate (Morales et al, 2008;Naik et al, 2005), dextran (Dou et al, 2008) and chitosan (Hernandez et al, 2009), using the coprecipitation method. The presence of starch molecules limited the size of the Fe 3 O 4 nanoparticles to 6 nm and the agglomeration of the coated nanoparticles was controlled upon the cleavage of the glycosidic bonds of the polymer, which allowed preparing magnetic composite particles with average size smaller than commercially available dextran-coated magnetic nanoparticles.…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%