In Situ Surface-Enhanced Raman Spectroelectrochemical Analysis System with a Hemin Modified Nanostructured Gold Surface

Surface- and tip-enhanced Raman spectroscopy (SERS and TERS) techniques exhibit highly localized chemical sensitivity, making them ideal for studying chemical reactions, including processes at catalytic surfaces. Catalyst structures, adsorbates, and reaction intermediates can be observed in low quantities at hot spots where electromagnetic fields are the strongest, providing ample opportunities to elucidate reaction mechanisms. Moreover, under ideal measurement conditions, it can even be used to trigger chemical reactions. However, factors such as substrate instability and insufficient signal enhancement still limit the applicability of SERS and TERS in the field of catalysis. By the use of sophisticated colloidal synthesis methods and advanced techniques, such as shell-isolated nanoparticle-enhanced Raman spectroscopy, these challenges could be overcome.

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confidence: 99%

Surface- and Tip-Enhanced Raman Spectroscopy in Catalysis

Hartman

Wondergem

Kumar

et al. 2016

J. Phys. Chem. Lett.

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160

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“…The usual materials that present plasmonic properties at the nanoscale are silver, gold and copper. Therefore, these metals can be used as electrodes for the detection of different molecules in Raman‐SEC .…”

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confidence: 99%

“…Raman‐SEC has been used to study the modification of a nanostructured Au electrode with a 4‐mercaptopyridine (MPy) self‐assembled monolayer and subsequent addition of hemin to the MPy surface . In this way, because of the SERS effect, a few thousands of molecules can be detected, obtaining important information about the shift of frequencies with the oxidation state.…”

Section: Advantages In Usementioning

confidence: 99%

Spectroelectrochemical Sensing: Current Trends and Challenges

et al. 2019

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Spectroelectrochemistry (SEC) has been used for more than 50 years, but this set of techniques has not been widely used for quantitative analysis. For many years, no commercial instruments were available, which made very difficult to spread the use of SEC. Nowadays, only the creativity of the researchers is required to exploit the capabilities of SEC. This review is written with the aim of showing the potential of SEC, mainly for analytical chemistry. Here, we explain what SEC is, how analytical responses can be obtained, why these techniques are useful for sensors, with a brief description of its advantages in use, and, finally, we try to show the challenges that must be addressed in the next years. SEC can resolve interesting analytical problems using the high amount of data provided by this intrinsic trilinear technique. Given the quantitative analysis point of view of this review, the discussion of the SEC techniques is focused on UV/Vis absorption, photoluminescence and Raman SEC.

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“…These gold nanowires could also be interfaced as electrodes to drive electrochemical reactions. A proof-of-concept study showed that it was possible to record shifts in the Raman spectrum upon oxidation and reduction of a monolayer of hemin attached to the gold electrode surface (54), as shown in Figure 3d.…”

Section: Novel Nanosensing Strategiesmentioning

confidence: 99%

Nanoscale Electrochemical Sensing and Processing in Microreactors

Odijk

Berg

2018

Annual Rev. Anal. Chem.

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In this review, we summarize recent advances in nanoscale electrochemistry, including the use of nanoparticles, carbon nanomaterials, and nanowires. Exciting developments are reported for nanoscale redox cycling devices, which can chemically amplify signal readout. We also discuss promising high-frequency techniques such as nanocapacitive CMOS sensor arrays or heterodyning. In addition, we review electrochemical microreactors for use in (drug) synthesis, biocatalysis, water treatment, or to electrochemically degrade urea for use in a portable artificial kidney. Electrochemical microreactors are also used in combination with mass spectrometry, e.g., to study the mimicry of drug metabolism or to allow electrochemical protein digestion. The review concludes with an outlook on future perspectives in both nanoscale electrochemical sensing and electrochemical microreactors. For sensors, we see a future in wearables and the Internet of Things. In microreactors, a future goal is to monitor the electrochemical conversions more precisely or ultimately in situ by combining other spectroscopic techniques.

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In Situ Surface-Enhanced Raman Spectroelectrochemical Analysis System with a Hemin Modified Nanostructured Gold Surface

Cited by 30 publications

References 34 publications

Surface- and Tip-Enhanced Raman Spectroscopy in Catalysis

Surface- and Tip-Enhanced Raman Spectroscopy in Catalysis

Spectroelectrochemical Sensing: Current Trends and Challenges

Nanoscale Electrochemical Sensing and Processing in Microreactors

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