In situ remineralizing effect of fluoride varnishes containing sodium trimetaphosphate

Manarelli, Michele Maurício; Delbem, Alberto Carlos Botazzo; Binhardi, Tiago Della Rovere; Pessan, Juliano Pelim

doi:10.1007/s00784-015-1492-6

Cited by 29 publications

(20 citation statements)

References 20 publications

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“…The varnish is also the agent of choice in function of its easy application and safety compared with other topical fluoride agents such as gels and rinses 27) . And a recent in situ study has found that fluoride varnish (5% NaF) could significantly remineralize the enamel and provide 50.1% surface hardness recovery 28) . Though the mechanical protection of varnish coating may be removed by toothbrushing or mastication in the oral cavity, it may also be expected that this loss will occur to a lesser extent in grooves and furrows in the approximal tooth surfaces 26) .…”

Section: Discussionmentioning

confidence: 99%

The effect of resin infiltration <i>vs.</i> fluoride varnish in enhancing enamel surface conditions after interproximal reduction

et al. 2016

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To assess the effect of resin infiltration vs. fluoride varnish in enhancing enamel surface conditions after interproximal reduction (IPR). After IPR procedures, 84 human enamel specimens were divided into three groups, group A/ group B was treated by fluoride varnish/resin infiltration according to the manufacturers' instructions, group C were treated with nothing. All the specimens were pH-cycled twice daily in 37°C bath for 30 days. Surface micro-hardness, density and mineral loss were measured before and after the pH cycling. The data were analyzed and compared using ANOVA. Both treatments A and B increased the surface microhardness of enamel after IPR (p<0.05). Both before and after pH cycling, the surface microhardness of A was significantly harder than B. The density of A was higher than B before pH cycling (p<0.05). Fluoride varnish and resin infiltration may provide an enamel protection from acid challenge.

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Section: Discussionmentioning

confidence: 99%

The effect of resin infiltration <i>vs.</i> fluoride varnish in enhancing enamel surface conditions after interproximal reduction

et al. 2016

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“…Sodium trimetaphosphate (TMP) has recently been shown to promote a synergistic remineralizing effect both in vitro 1 and in situ 2 when added to fluoride (F) varnishes. However, considering the complex interactions between F and TMP and the scarcity of studies assessing the association between these compounds in varnish formulations, investigating the patterns of the release of F and TMP from these products would be informative, as interactions between NaF and TMP salts, as well as among other varnish components, could potentially affect the efficacy of the products.…”

Section: Introductionmentioning

confidence: 99%

Fluoride and sodium trimetaphosphate (TMP) release from fluoride varnishes supplemented with TMP

et al. 2016

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Fluoride and sodium trimetaphosphate (TMP) release from fluoride varnishes supplemented with TMP Abstract: This study assessed fluoride (F) and sodium trimetaphosphate (TMP) release into artificial saliva from varnishes containing 0%, 2.5%, and 5% NaF, supplemented or not with 5% TMP. The varnishes were applied on polyester sheets (n = 8/group), and F and TMP released into artificial saliva were measured for up to 24 hours. The amount of F and TMP released were directly related to NaF and TMP concentrations in the varnishes. The highest F release was seen for 5% NaF and 5% NaF + 5% TMP, whereas 5% TMP released the highest amount of TMP. However, the simultaneous addition of NaF and TMP to varnishes significantly reduced the amount of F and TMP released from the products.

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“…On the other hand, the capacity of TMP to enhance the remineralizing effect of 500 ppm F mainly in depth ( fig. 2 b, table 2 : IH R , zone B) can also be related to the ability of TMP in reducing the deposition of CaF 2 Manarelli et al, 2015]. Such an effect might understate the obstruction of enamel pores, thus facilitating ion diffusion into enamel.…”

Section: Discussionmentioning

confidence: 99%

“…Such an effect might understate the obstruction of enamel pores, thus facilitating ion diffusion into enamel. In the same way, TMP adsorbed on enamel binds to Ca 2+ and CaF + ions [Takeshita et al, 2015;Manarelli et al, 2015], which produces a direct impact on calcium, phosphate and fluoride uptake by enamel ( table 1 ). Finally, as an in situ model was used and given that enamel remineralization was significantly enhanced for the 500 ppm F + TMP group in comparison with 500 ppm F ( table 2 ), the present results showed that this phosphate can also be adsorbed by organic and inorganic components on the acquired pellicle [Nordbö and Rölla, 1972], even if the exact mechanisms of such interactions remain unknown.…”

Section: Discussionmentioning

confidence: 99%

“…placebo, 500 ppm F, 500 ppm F + TMP and 1,100 ppm F group values minus the subsurface enamel demineralization) for each volunteer. These differential profiles were then integrated over two depth zones in the lesion: zone A, 5-50 μm (outer region of subsurface lesion), and zone B, 50-110 μm (inner region of subsurface lesion), to yield integrated recovery hardness (IH R ) values Manarelli et al, 2015].…”

Section: Hardness Analysismentioning

confidence: 99%

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Remineralizing Potential of a Low Fluoride Toothpaste with Sodium Trimetaphosphate: An in situ Study

Takeshita

Danelon²,

Castro³

et al. 2016

Caries Res

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Objective: To evaluate the effect of a low-fluoride (F) toothpaste supplemented with sodium trimetaphosphate (TMP) on enamel remineralization in situ. Design: Bovine enamel blocks were selected on the basis of their surface hardness (SH) after caries-like lesions had been induced, and randomly divided into 4 treatment groups, according to the toothpastes used: without F or TMP (placebo); 500 ppm F; 500 ppm F plus 1% TMP; and 1,100 ppm F. The study design was blinded and crossover and performed in 4 phases of 3 days each. Eleven subjects used palatal appliances containing 4 bovine enamel blocks which were treated 3 times per day during 1 min each time, with natural slurries of saliva and toothpaste formed in the oral cavity during toothbrushing. After each phase, the percentages of surface (%SH_R) and subsurface hardness recovery (%ΔKHN_R) were calculated. F, calcium (Ca), and phosphorus (Pi) contents in enamel were also determined. Data were analyzed by 1-way, repeated-measures ANOVA, followed by the Student-Newman-Keuls test (p < 0.05). Results: Toothpaste with 500 ppm F + TMP and 1,100 ppm F showed similar %SH_R and %ΔKHN_R as well as enamel F, Ca, and Pi concentrations. Conclusion: The addition of TMP to a low-fluoride toothpaste promoted a similar remineralizing capacity to that of a standard (1,100 ppm F) toothpaste in situ.

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In situ remineralizing effect of fluoride varnishes containing sodium trimetaphosphate

Abstract: The reduction in the subsurface lesion area of enamel treated with the TMP-containing varnish implies that cavities would take longer to develop or might not develop at all depending on individual factors, resulting in lower net caries increments at individual and population levels.

Cited by 29 publications

References 20 publications

The effect of resin infiltration <i>vs.</i> fluoride varnish in enhancing enamel surface conditions after interproximal reduction

The effect of resin infiltration <i>vs.</i> fluoride varnish in enhancing enamel surface conditions after interproximal reduction

Fluoride and sodium trimetaphosphate (TMP) release from fluoride varnishes supplemented with TMP

Remineralizing Potential of a Low Fluoride Toothpaste with Sodium Trimetaphosphate: An in situ Study

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