In situ recognition of molecular chirality by mass spectrometry

Nikolaev, Eugene; Popov, Igor; Kharybin, Oleg N.; Kononikhin, Alexey; Nikolaeva, Marina; Borisov, Yurij V.

doi:10.1016/j.ijms.2007.04.001

Cited by 6 publications

(3 citation statements)

References 14 publications

(14 reference statements)

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“…In fact, addition of one molecule was observed to make the heterodimeric complex more stable than the homodimeric complex. Further additions of two or more water molecules to the complex completely abolished the influence of chirality in dimer ion stability [81].…”

Section: Gas Phase Molecular Recognition Properties Of Tartratesmentioning

confidence: 96%

“…To our knowledge Arakawa et al reported the first use of metal-tartrates as a chiral reference to study enantioselective discrimination by this compound class using MS [81]. 2 -were shown to increase and decrease, respectively, with time as (+)-2-THC underwent racemization to the ( -)-isomer (and vice versa) in solution.…”

Section: Gas Phase Molecular Recognition Properties Of Metal-tartratesmentioning

confidence: 99%

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Molecular recognition properties of tartrates and metal‐tartrates in solution and gas phase

Wijeratne

Schug²

2009

J of Separation Science

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Section: Gas Phase Molecular Recognition Properties Of Tartratesmentioning

confidence: 96%

Section: Gas Phase Molecular Recognition Properties Of Metal-tartratesmentioning

confidence: 99%

Molecular recognition properties of tartrates and metal‐tartrates in solution and gas phase

Wijeratne

Schug²

2009

J of Separation Science

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“…71 Interesting investigations on mass spectrometric discrimination of chiral compounds have been performed by joint collaboration of a number of institutes with the participation of Eugene Nikolaev. 72 Using enantiomeric dimethyl tartrates and direct probing, the vapors of the analyte at the atmospheric pressure conditions (corona discharge chemical ionization and surface thermoionization), it has been shown that both ionization methods produce cationized dimers and trimers of dimethyltartrate molecules with pronounced effects of chiral discrimination. In the case of corona discharge ionization, the chirality affected the formation of both H 3 O + and H 2 O + based adducts of dimers and trimers.…”

Section: Stereoisomersmentioning

confidence: 99%

Mass Spectrometry in Russia

Заикин

Сысоев

2013

Eur J Mass Spectrom (Chichester)

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The present review covers the main research in the area of mass spectrometry from the 1990s which was about the same time as the Russian Federation emerged from the collapse of the Soviet Union (USSR). It consists of two main parts-application of mass spectrometry to chemistry and related fields and creation and development of mass spectrometric technique. Both traditional and comparatively new mass spectrometric methods were used to solve various problems in organic chemistry (reactivity of gas-phase ions, structure elucidation and problems of identification, quantitative and trace analysis, differentiation of stereoisomers, derivatization approaches etc.), biochemistry (proteomics and peptidomics, lipidomics), medical chemistry (mainly the search of biomarkers, pharmacology, doping control), environmental, petrochemistry, polymer chemistry, inorganic and physical chemistry, determination of natural isotope ratio etc. Although a lot of talented mass spectrometrists left Russia and moved abroad after the collapse of the Soviet Union, the vitality of the mass spectral community proved to be rather high, which allowed the continuation of new developments in the field of mass spectrometric instrumentation. They are devoted to improvements in traditional magnetic sector mass spectrometers and the development of new ion source types, to analysis and modification of quadrupole, time-of-flight (ToF) and ion cyclotron resonance (ICR) analyzers. The most important achievements are due to the creation of multi-reflecting ToF mass analyzers. Special attention was paid to the construction of compact mass spectrometers, particularly for space exploration, of combined instruments, such as ion mobility spectrometer/mass spectrometer and accelerating mass spectrometers. The comparatively young Russian Mass Spectrometry Society is working hard to consolidate the mass spectrometrists from Russia and foreign countries, to train young professionals on new appliances and regularly holds conferences on mass spectrometry. For ten years, a special journal Mass-spektrometria has published papers on all disciplines of mass spectrometry.

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Synergistic Effects of Trace Amounts of Water in the Enantiodiscrimination Processes by Lipodex E: A Spectroscopic and Computational Investigation

et al. 2014

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Nuclear magnetic resonance (NMR) investigations on mixtures containing octakis(3-O-butanoyl-2,6-di-O-pentyl)-γ-cyclodextrin (Lipodex E) and each enantiomer of methyl-2-chloropropionate (MCP) ascertained the role of trace amounts of water in the enantiodiscrimination processes. Water is deeply included into the cyclodextrin and favors the formation of the inclusion complex with (S)-MCP, whereas (R)-MCP is only slightly affected, thus causing a significant increase of NMR differentiation. Molecular dynamics simulations were performed to shed light on the possible behavior of Lipodex E in different conditions (i.e., solvent, inclusion complexes), providing energetic and atomistic details that are in agreement with NMR observations.

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In situ recognition of molecular chirality by mass spectrometry

Cited by 6 publications

References 14 publications

Molecular recognition properties of tartrates and metal‐tartrates in solution and gas phase

Molecular recognition properties of tartrates and metal‐tartrates in solution and gas phase

Mass Spectrometry in Russia

Synergistic Effects of Trace Amounts of Water in the Enantiodiscrimination Processes by Lipodex E: A Spectroscopic and Computational Investigation

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