In situ photothermal activation of necroptosis potentiates black phosphorus-mediated cancer photo-immunotherapy

Zhao, Henan; Chen, Haolin; Guo, Zhouyi; Zhang, Wen; Yu, Hongfeng; Zhuang, Zhengfei; Zhong, Huiqing; Liu, Zhiming

doi:10.1016/j.cej.2020.124314

Cited by 71 publications

(35 citation statements)

References 49 publications

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“…The combined cancer treatment modality can both improve their therapeutic efficacy and lower side effects. PTT/IT BPNSs-DcF@sPL Circumvent PL pathway-regulated immune tolerance and suppression of CD8 + T cells, enhance the IFN-γ expression and promote the survival rate [131] FKF-OVAp@BPNSs Enhance antigen uptake, activate systemic immunity and prolong the survival time [135] BPNSs-bPEI-PEG-CpG Induce necroptotic cell death, activate T lymphocytes, increase serum IL-2, TNF-α and IFN-γ level, suppress both primary and distal tumors [138] hEX@BPNSs Activate immune system, inhibit tumor progression and prolong survival [141] BPNSs + aCD47…”

Section: Synergistic Cancer Photoimmunotherapy Based On Black Phosphorus Nanomaterialsmentioning

confidence: 99%

“…Therefore, immunostimulatory adjuvants are developed to both activate the innate immune responses and trigger tumor-specific immune responses [ 137 ]. Zhao and his colleagues reported the integration of bPEI-PEG coated BPNSs and CpG via electrostatic interaction [ 138 ]. Taking advantage of the necroptotic pathway mediated by BP nanomaterials based-PTT, damage-associated molecular patterns (DAMPs) were released from the necroptotic cells to reinforce the anticancer immune responses.…”

Section: Delivery Of Immunotherapeutic Agents For Cancer Immunotherapymentioning

confidence: 99%

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Black Phosphorus, an Emerging Versatile Nanoplatform for Cancer Immunotherapy

et al. 2021

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Black phosphorus (BP) is one of the emerging versatile nanomaterials with outstanding biocompatibility and biodegradability, exhibiting great potential as a promising inorganic nanomaterial in the biomedical field. BP nanomaterials possess excellent ability for valid bio-conjugation and molecular loading in anticancer therapy. Generally, BP nanomaterials can be classified into BP nanosheets (BPNSs) and BP quantum dots (BPQDs), both of which can be synthesized through various preparation routes. In addition, BP nanomaterials can be applied as photothermal agents (PTA) for the photothermal therapy (PTT) due to their high photothermal conversion efficiency and larger extinction coefficients. The generated local hyperpyrexia leads to thermal elimination of tumor. Besides, BP nanomaterials are capable of producing singlet oxygen, which enable its application as a photosensitizer for photodynamic therapy (PDT). Moreover, BP nanomaterials can be oxidized and degraded to nontoxic phosphonates and phosphate under physiological conditions, improving their safety as a nano drug carrier in cancer therapy. Recently, it has been reported that BP-based PTT is capable of activating immune responses and alleviating the immunosuppressive tumor microenvironment by detection of T lymphocytes and various immunocytokines, indicating that BP-based nanocomposites not only serve as effective PTAs to ablate large solid tumors but also function as an immunomodulation agent to eliminate discrete tumorlets. Therefore, BP-mediated immunotherapy would provide more possibilities for synergistic cancer treatment.

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Section: Synergistic Cancer Photoimmunotherapy Based On Black Phosphorus Nanomaterialsmentioning

confidence: 99%

Section: Delivery Of Immunotherapeutic Agents For Cancer Immunotherapymentioning

confidence: 99%

Black Phosphorus, an Emerging Versatile Nanoplatform for Cancer Immunotherapy

et al. 2021

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“…Apart from loading strategy,CpG ODNs could be grafted onto nanomaterials to potentiate cancer PTT/immunotherapy.I narepresentative study, [52] CpG ODNs were grafted onto the surface of PEG-polyethylenimine modified black phosphorus (BP) nanosheets via electrostatic bonding.B P served as aN IR-responsive nanoagent to exert PTT upon 808 nm laser irradiation, resulting in necroptosis of tumor cells and ICD with the release of DAMPs.T hese generated ICD biomarkers combined with CpG ODNs increased the populations of CD4 + and CD8 + Tc ells in tumors by more than 26-fold, and obviously decreased the content of T reg cells. As aresult, the BP-based nanocomposite not only acted as an effective PTT nanoagent for photothermal ablation of large solid tumors,b ut also served as an immunoactivator to eliminate discrete tumors.…”

Section: Combination Of Ptt With Adjuvant Immunotherapymentioning

confidence: 99%

Electromagnetic Nanomedicines for Combinational Cancer Immunotherapy

Luo

2021

Angewandte Chemie

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Immunotherapy that harnesses the power of the immune system to eliminate malignant cells has offered an effective approach for cancer treatment. However, limited patient response rates and potential immune‐related adverse events exist as two major issues for cancer immunotherapy. In parallel, a variety of electromagnetic nanomaterials that generate heat and/or reactive oxygen species triggered by electromagnetic energy have been applied for magnetic hyperthermia therapy, sonodynamic therapy, photothermal therapy, photodynamic therapy, and radiotherapy, which have the ability to induce immunogenic cell death. This review summarizes the recent development of electromagnetic nanomedicines in combinational cancer immunotherapy. The mechanisms of electromagnetic nanomedicines in reprogramming the immunosuppressive tumor microenvironment and sensitizing tumors for cancer immunotherapy are highlighted. Furthermore, potential challenges and perspectives of electromagnetic nanomedicines for combinational cancer immunotherapy are discussed.

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“…2D nanomaterials have also been used for immunogenic PTT as shown by Zhao et al [27], who synthesized black phosphorus 2D nanosheets with high PTT efficiency that caused ICD. This was characterized by an increase in TNF-α and IL-6 in serum as well as the expression of necrotic proteins such as RIP1 and RIP3.…”

Section: Photothermal Therapymentioning

confidence: 99%

Immunogenicity of Externally Activated Nanoparticles for Cancer Therapy

Sahin

Ashokkumar

Ajayan

et al. 2020

Cancers

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Nanoparticles activated by external beams, such as ionizing radiation, laser light, or magnetic fields, have attracted significant research interest as a possible modality for treating solid tumors. From producing hyperthermic conditions to generating reactive oxygen species, a wide range of externally activated mechanisms have been explored for producing cytotoxicity within tumors with high spatiotemporal control. To further improve tumoricidal effects, recent trends in the literature have focused on stimulating the immune system through externally activated treatment strategies that result in immunogenic cell death. By releasing inflammatory compounds known to initiate an immune response, treatment methods can take advantage of immune system pathways for a durable and robust systemic anti-tumor response. In this review, we discuss recent advancements in radiosensitizing and hyperthermic nanoparticles that have been tuned for promoting immunogenic cell death. Our review covers both preclinical and clinical results, as well as an overview of possible future work.

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In situ photothermal activation of necroptosis potentiates black phosphorus-mediated cancer photo-immunotherapy

Cited by 71 publications

References 49 publications

Black Phosphorus, an Emerging Versatile Nanoplatform for Cancer Immunotherapy

Black Phosphorus, an Emerging Versatile Nanoplatform for Cancer Immunotherapy

Electromagnetic Nanomedicines for Combinational Cancer Immunotherapy

Immunogenicity of Externally Activated Nanoparticles for Cancer Therapy

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