In situ magnesium calcium phosphate cements formation: From one pot powders precursors synthesis to in vitro investigations

Goldberg, M. A.; Krohicheva, P.A.; Фомин, А. С.; Хайрутдинова, Д. Р.; Антонова, О. С.; Баикин, А. С.; Смирнов, В. В.; Fomina, A. A.; Леонов, А. В.; Mikheev, Ivan V.; Сергеева, Н. С.; Ахмедова, С. А.; Баринов, С. М.; Komlev, V. S.

doi:10.1016/j.bioactmat.2020.03.011

Cited by 26 publications

(23 citation statements)

References 31 publications

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“…We should also note that the growth of crystals that inhibit cell adhesion on the alloy surface can be inhibited (at least in the early stages of implantation, which is especially important for cell growth) by applying biodegradable coatings. Promising candidates for this role are materials based on calcium phosphate cements [33,34]. Not only are such coatings able to inhibit the degradation of magnesium at the early stages of implantation (and, therefore, to reduce the undesirable growth of crystals and the rate of hydrogen release), but they may also boost the biocompatibility of the finished products.…”

Section: Discussionmentioning

confidence: 99%

Modification of Biocorrosion and Cellular Response of Magnesium Alloy WE43 by Multiaxial Deformation

Anisimova

Martynenko

Новрузов

et al. 2022

Metals

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The study shows that multiaxial deformation (MAD) treatment leads to grain refinement in magnesium alloy WE43. Compared to the initial state, the MAD-processed alloy exhibited smoother biocorrosion dynamics in a fetal bovine serum and in a complete cell growth medium. Examination by microCT demonstrated retardation of the decline in the alloy volume and the Hounsfield unit values. An attendant reduction in the rate of accumulation of the biodegradation products in the immersion medium, a less pronounced alkalization, and inhibited sedimentation of biodegradation products on the surface of the alloy were observed after MAD. These effects were accompanied with an increase in the osteogenic mesenchymal stromal cell viability on the alloy surface and in a medium containing their extracts. It is expected that the more orderly dynamics of biodegradation of the WE43 alloy after MAD and the stimulation of cell colonization will effectively promote stable osteosynthesis, making repeat implant extraction surgeries unnecessary.

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Section: Discussionmentioning

confidence: 99%

Modification of Biocorrosion and Cellular Response of Magnesium Alloy WE43 by Multiaxial Deformation

Anisimova

Martynenko

Новрузов

et al. 2022

Metals

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“…The significance of calcium compounds for the stimulation of osteogenic differentiation of MMSCs has been studied in a number of works considering the bioactivity of calcium-containing matrices that are promising for accelerating osteosynthesis [58,59]. In our opinion, it is advisable to use a coating, for example, a calcium phosphate one, as a further means of modification of the material [60,61]. This will not only slow down the biodegradation rate in the early stages of injury healing but also stimulate the growth and proliferation of osteoblasts.…”

Section: Discussionmentioning

confidence: 99%

Rationale for Processing of a Mg-Zn-Ca Alloy by Equal-Channel Angular Pressing for Use in Biodegradable Implants for Osteoreconstruction

et al. 2021

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Widespread use of Mg-Zn-Ca alloys in clinical orthopedic practice requires improvement of their mechanical properties—in particular, ductility—and enhancement of their bioactivity for accelerated osteoreconstruction. The alloy was studied in two structural states: after homogenization and after equal-channel angular pressing. Immersion and potentiodynamic polarization tests showed that the corrosion rate of the alloy was not increased by deformation. The mass loss in vivo was also statistically insignificant. Furthermore, it was found that deformation did not compromise the biocompatibility of the alloy and did not have any significant effect on cell adhesion and proliferation. However, an extract of the alloy promoted the alkaline phosphatase activity of human mesenchymal stromal cells, which indicates osteogenic stimulation of cells. The osteoinduction of the deformed alloy significantly exceeded that of the homogenized one. Based on the results of this work, it can be concluded that the alloy Mg-1%Zn-0.3%Ca modified by equal-channel angular pressing is a promising candidate for the manufacture of biodegradable orthopedic implants since it stimulates osteogenic differentiation and has greater ductility, which provides it with a competitive advantage in comparison with the homogenized state.

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“…Since Mg is a common substitute for Ca in natural bone tissue, so Mg-based materials are often added into CaP cement to form MCP cement to increase their setting time and mechanical properties. 20,79,80…”

Section: Magnesium Phosphate Cementsmentioning

confidence: 99%

Biodegradable magnesium phosphates in biomedical applications

et al. 2022

J. Mater. Chem. B

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In situ magnesium calcium phosphate cements formation: From one pot powders precursors synthesis to in vitro investigations

Cited by 26 publications

References 31 publications

Modification of Biocorrosion and Cellular Response of Magnesium Alloy WE43 by Multiaxial Deformation

Modification of Biocorrosion and Cellular Response of Magnesium Alloy WE43 by Multiaxial Deformation

Rationale for Processing of a Mg-Zn-Ca Alloy by Equal-Channel Angular Pressing for Use in Biodegradable Implants for Osteoreconstruction

Biodegradable magnesium phosphates in biomedical applications

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