1981
DOI: 10.2340/0001555561371380
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In situ identification of mononuclear cells in cutaneous infiltrates in discoid lupus erythematosus, sarcoidosis and secondary syphilis

Abstract: The inflammatory mononuclear cell infiltrates observed in lesional skin from patients with discoid lupus erythematosus (DLE), sarcoidosis, and secondary syphilis have been characterized in situ. Immunological markers (human T lymphocyte antigens and receptors for sheep erythrocytes, C3b, C3d and Fc gamma) were studied by using immunofluorescence tests with IgG F (ab´)2 preparation of anti-T lymphocyte serum, hemadsorption with tissue sections, and tests with soluble immune complexes of peroxidase. In DLE, T ly… Show more

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Cited by 25 publications
(6 citation statements)
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“…Such ANAE-negative T cells have been purified from human adenoids and tonsils in high percentages (18). The percentage of OKT-3 + T cells in the LP lesions was close to 60, which is in agreement with the figures (65 %) reported by Braathen et al ( 2), but somewhat lower than that (75 %) by Bjerke (5). No significant changes were observed in the relative proportions of B and T cells following PUVA therapy (Table I).…”
Section: Discussionsupporting
confidence: 89%
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“…Such ANAE-negative T cells have been purified from human adenoids and tonsils in high percentages (18). The percentage of OKT-3 + T cells in the LP lesions was close to 60, which is in agreement with the figures (65 %) reported by Braathen et al ( 2), but somewhat lower than that (75 %) by Bjerke (5). No significant changes were observed in the relative proportions of B and T cells following PUVA therapy (Table I).…”
Section: Discussionsupporting
confidence: 89%
“…This dermal infiltrate consists mainly of lympho cytes, most of them T celJs, and some macrophages (I, 2, 3). By defining the T cell subpopulations in LP lesions with monoclonal antisera, predominance of helper/inducer subset over the suppressor/cytotoxic one has been reported (4,5,6). Other recent studies, however, suggest that the T suppressor/cytotoxic subset would be responsible for the characteristic degenerative lytic process in the basal keratinocytes of LP lesions (7,8).…”
mentioning
confidence: 99%
“…When compared with the valuc� in periph cral blood f r om normal control:, (approximately 35 o/c suppre�sor/cytotoxic cells) (20), therc i!> a reduced number of suppre�sor/cytotoxic T lympho cyte� in lesions of psoriasi� and DLE. Lo� numbers of supprcssor T lymphocytes in psoriatic lcsions were also indicated by the results obtained using �taining for ANAE activity (3).…”
Section: Discussionmentioning
confidence: 75%
“…The results accord with our previous data obtained using hem adsorption of sheep erythrocytes to cryostat sec tions (4, 5. 6), an immunofluorescence test with a rabbit antiserum against T lymphocytes (3,6) and staining for a-naphthyl acetate esterase (ANAE) activity (3).…”
Section: Discussionmentioning
confidence: 99%
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