In Situ Hexosomal Gel as a Promising Tool to Ameliorate the Transnasal Brain Delivery of Vinpocetine: Central Composite Optimization and In Vivo Biodistribution

Bakr, Mohamed Mofreh; Shukr, Marwa Hassan; ElMeshad, Aliaa Nabil

doi:10.1016/j.xphs.2020.03.030

Cited by 19 publications

(8 citation statements)

References 42 publications

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“…Chitosan-methyl cellulose sol–gels loaded with cubosomes have also exhibited better sustained release behavior of a vaccine in vivo than the P407–25R4 cubosomal gels . In the case of hexosomes, they have been loaded into carrageenan-based thermos-reversible hydrogels or an in situ gellan gum gel . However, it is noteworthy that the loading of cubosomes or hexosomes may affect the gelation process of polymers, resulting in a lower transition temperature and reduced complex viscosity.…”

Section: Combination With Other Encapsualtion Methodsmentioning

confidence: 99%

“…121 In the case of hexosomes, they have been loaded into carrageenan-based thermos-reversible hydrogels 122 or an in situ gellan gum gel. 123 However, it is noteworthy that the loading of cubosomes or hexosomes may affect the gelation process of polymers, resulting in a lower transition temperature and reduced complex viscosity. For example, the lipid concentrations of 15 μmol/mL can reduce chitosan gel strength by interfering with the physical crosslinking of chitosan.…”

Section: ■ Application As Nanocarriers For Bioactive Compoundsmentioning

confidence: 99%

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Cubosomes and Hexosomes as Novel Nanocarriers for Bioactive Compounds

Tan

Hosseini

Jafari

2022

J. Agric. Food Chem.

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Cubosomes and hexosomes are nanostructured liquid crystalline particles, known as biocompatible nanocarriers for drug delivery. In recent years, there has been good interest in using cubosomes and hexosomes for the delivery of bioactive compounds in functional foods. These systems feature thermodynamic stability, encapsulate both hydrophobic and hydrophilic substances, and have a high tolerance to environmental stresses and potential for controlled release. This review outlines the recent advances in cubosomes and hexosomes in the food industry, focusing on their structure, composition, formation mechanisms, and factors influencing phase transformation between cubosomes and hexosomes. The potential applications especially for the bioactive delivery are presented. The integration of cubosomes and hexosomes with other emerging encapsulation technologies such as surface coating, gelation, and incorporation of polymers are also discussed.

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Section: Combination With Other Encapsualtion Methodsmentioning

confidence: 99%

Section: ■ Application As Nanocarriers For Bioactive Compoundsmentioning

confidence: 99%

Cubosomes and Hexosomes as Novel Nanocarriers for Bioactive Compounds

Tan

Hosseini

Jafari

2022

J. Agric. Food Chem.

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“…To examine the morphological characteristics of the formed nanostructures, each formula was negatively stained by 2% w/v phosphotungistic acid. A one drop of diluted formulations was mounted on carbon coated copper grid, stained, dried at room temperature and examined by TEM ( 33 ).…”

Section: Methodsmentioning

confidence: 99%

Scrutinizing the Feasibility of Nonionic Surfactants to Form Isotropic Bicelles of Curcumin: a Potential Antiviral Candidate Against COVID-19

et al. 2021

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Investigating bicelles as an oral drug delivery system and exploiting their structural benefits can pave the way to formulate hydrophobic drugs and potentiate their activity. Herein, the ability of non-ionic surfactants (labrasol®, tween 80, cremophore EL and pluronic F127) to form curcumin loaded bicelles with phosphatidylcholine, utilizing a simple method, was investigated. Molecular docking was used to understand the mechanism of bicelles formation. The % transmittance and TEM exhibited bicelles formation with labrasol® and tween 80, while cremophor EL and pluronic F127 tended to form mixed micelles. The surfactant-based nanostructures significantly improved curcumin dissolution (99.2 ± 2.6% within 10 min in case of tween 80-based bicelles) compared to liposomes and curcumin suspension in non-sink conditions. The prepared formulations improved curcumin ex vivo permeation over liposomes and drug suspension. Further, the therapeutic antiviral activity of the formulated curcumin against SARS-CoV-2 was potentiated over drug suspension. Although both Labrasol® and tween 80 bicelles could form bicelles and enhance the oral delivery of curcumin when compared to liposomes and drug suspension, the mixed micelles formulations depicted superiority than bicelles formulations. Our findings provide promising formulations that can be utilized for further preclinical and clinical studies of curcumin as an antiviral therapy for COVID-19 patients.

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“…This aids in understanding the shape of the formed vesicles. One drop of the diluted sample (with distilled water) was placed on carbon-coated copper grid and negatively stained using phosphotungistic acid (1% w/v) and allowed to dry at ambient temperature prior to visualization by means of a transmission electron microscope (JEM-1230, JEOL, Japan) …”

Section: Experimental Methodsmentioning

confidence: 99%

“…One drop of the diluted sample (with distilled water) was placed on carbon-coated copper grid and negatively stained using phosphotungistic acid (1% w/v) and allowed to dry at ambient temperature prior to visualization by means of a transmission electron microscope (JEM-1230, JEOL, Japan). 24 Tendency of Crownsomes for Corneal Calcium Extraction. To investigate the possible mechanism of the corneal penetration of the formulated crownsomes dispersions, the ability of the formulation to extract calcium ions from bovine cornea was evaluated utilizing atomic absorption spectrometry.…”

Section: ■ Experimental Methodsmentioning

confidence: 99%

Crown Ether Nanovesicles (Crownsomes) Repositioned Phenytoin for Healing of Corneal Ulcers

2020

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Drug repositioning is an important drug development strategy as it saves the time and efforts exerted in drug discovery. Since reepithelization of the cornea is a critical problem, we envisioned that the anticonvulsant phenytoin sodium can promote reepithelization of corneal ulcers as it was repurposed for skin wound healing. Herein, our aim is to develop novel crown ether-based nanovesicles “Crownsomes” of phenytoin sodium for ocular delivery with minimal drug-induced irritation and enhanced efficacy owing to “host–guest” properties of crown ethers. Crownsomes were successfully fabricated using span-60 and 18-crown-6 and their size, morphology, polydispersity index, ζ potential, drug loading efficiency, conductivity, and drug release were characterized. Crownsomes exhibited favorable properties such as formation of spherical nanovesicles of 280 ± 18 nm and −26.10 ± 1.21 mV surface charges. Crownsomes depicted a high entrapment efficiency (77 ± 5%) with enhanced and controlled-release pattern of phenytoin sodium. The optimum crownsomes formulation ameliorated ex vivo corneal drug permeability (1.78-fold than drug suspension) through the corneal calcium extraction ability of 18-crown-6. In vivo study was conducted utilizing an alkali-induced corneal injury rabbit model. Clinical and histopathological examination confirmed that crownsomes exhibited better biocompatibility and minimal irritation due to complex formation and drug shielding. Further, they enhanced corneal healing, indicating their effectiveness as a novel drug delivery system for ocular diseases.

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In Situ Hexosomal Gel as a Promising Tool to Ameliorate the Transnasal Brain Delivery of Vinpocetine: Central Composite Optimization and In Vivo Biodistribution

Cited by 19 publications

References 42 publications

Cubosomes and Hexosomes as Novel Nanocarriers for Bioactive Compounds

Cubosomes and Hexosomes as Novel Nanocarriers for Bioactive Compounds

Scrutinizing the Feasibility of Nonionic Surfactants to Form Isotropic Bicelles of Curcumin: a Potential Antiviral Candidate Against COVID-19

Crown Ether Nanovesicles (Crownsomes) Repositioned Phenytoin for Healing of Corneal Ulcers

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